Survival of the fittest: in vivo selection and stem cell gene therapy (Q36306141)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16269617%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

review article

1 reference

title

Survival of the fittest: in vivo selection and stem cell gene therapy (English)

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8 January 2020

0 references

1

1 reference

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8 January 2020

3

Hans-Peter Kiem

1 reference

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8 January 2020

author name string

Brian C Beard

series ordinal

2

1 reference

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8 January 2020

language of work or name

English

0 references

publication date

3 November 2005

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8 January 2020

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8 January 2020

volume

107

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8 January 2020

issue

5

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8 January 2020

page(s)

1751-1760

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A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M

8 January 2020

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30 September 2017

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30 September 2017

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Reconstitution of lymphoid development and function in ZAP-70-deficient mice following gene transfer into bone marrow cells

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Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells

30 September 2017

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30 September 2017

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Drug selection with paclitaxel restores expression of linked IL-2 receptor gamma -chain and multidrug resistance (MDR1) transgenes in canine bone marrow

30 September 2017

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Correction of sickle cell disease in transgenic mouse models by gene therapy

30 September 2017

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Targeted disruption of the murine Fanconi anemia gene, Fancg/Xrcc9

30 September 2017

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Somatic mosaicism in Wiskott--Aldrich syndrome suggests in vivo reversion by a DNA slippage mechanism.

30 September 2017

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Variable correction of host defense following gene transfer and bone marrow transplantation in murine X-linked chronic granulomatous disease

30 September 2017

1 reference

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Pharmacologically regulated cell therapy

30 September 2017

1 reference

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Somatic mosaicism in Fanconi anemia: evidence of genotypic reversion in lymphohematopoietic stem cells.

30 September 2017

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Generation of dual resistance to 4-hydroperoxycyclophosphamide and methotrexate by retroviral transfer of the human aldehyde dehydrogenase class 1 gene and a mutated dihydrofolate reductase gene

30 September 2017

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Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents

30 September 2017

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Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling

30 September 2017

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Direct reversal of DNA damage by mutant methyltransferase protein protects mice against dose-intensified chemotherapy and leads to in vivo selection of hematopoietic stem cells

30 September 2017

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30 September 2017

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30 September 2017

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Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease

30 September 2017

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30 September 2017

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Paclitaxel chemotherapy after autologous stem-cell transplantation and engraftment of hematopoietic cells transduced with a retrovirus containing the multidrug resistance complementary DNA (MDR1) in metastatic breast cancer patients

30 September 2017

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STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells

30 September 2017

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T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34+ cells in ADA-deficient SCID neonates.

30 September 2017

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Results of MDR-1 vector modification trial indicate that granulocyte/macrophage colony-forming unit cells do not contribute to posttransplant hematopoietic recovery following intensive systemic therapy

30 September 2017

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Retroviral transduction of a mutant methylguanine DNA methyltransferase gene into human CD34 cells confers resistance to O6-benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosourea

30 September 2017

1 reference

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Improved retroviral gene transfer into murine and Rhesus peripheral blood or bone marrow repopulating cells primed in vivo with stem cell factor and granulocyte colony-stimulating factor

30 September 2017

1 reference

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Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia

30 September 2017

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Long-term engraftment of normal and post-5-fluorouracil murine marrow into normal nonmyeloablated mice.

30 September 2017

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Behavior of hematopoietic stem cells in a large animal

30 September 2017

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Structure, function, and inhibition of O6-alkylguanine-DNA alkyltransferase.

30 September 2017

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30 September 2017

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30 September 2017

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29 June 2018

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Retroviral-mediated expression of recombinant Fancc enhances the repopulating ability of Fancc-/- hematopoietic stem cells and decreases the risk of clonal evolution

29 June 2018

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Preclinical protocol for in vivo selection of hematopoietic stem cells corrected by gene therapy in Fanconi anemia group C.

29 June 2018

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29 June 2018

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In vivo selection of retrovirally transduced hematopoietic stem cells

29 June 2018

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29 June 2018

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29 June 2018

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29 June 2018

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Cytokine prestimulation as a gene therapy strategy: implications for using the MDR1 gene as a dominant selectable marker

29 June 2018

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The hematological effects of folate analogs: implications for using the dihydrofolate reductase gene for in vivo selection

29 June 2018

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Mutations in the Ada O6-alkylguanine-DNA alkyltransferase conferring sensitivity to inactivation by O6-benzylguanine and 2,4-diamino-6-benzyloxy-5-nitrosopyrimidine

29 June 2018

1 reference

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Gene therapy in peripheral blood lymphocytes and bone marrow for ADA- immunodeficient patients

29 June 2018

1 reference

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Canine model for gene therapy: inefficient gene expression in dogs reconstituted with autologous marrow infected with retroviral vectors

29 June 2018

1 reference

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Serial transplantation of methotrexate-resistant bone marrow: protection of murine recipients from drug toxicity by progeny of transduced stem cells

29 June 2018

1 reference

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Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents

29 June 2018

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Mixed chimerism in thalassemic patients after bone marrow transplantation

29 June 2018

1 reference

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Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1

29 June 2018

1 reference

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The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J

29 June 2018

1 reference

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Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking.

22 September 2018

1 reference

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Leukemias following retroviral transfer of multidrug resistance 1 (MDR1) are driven by combinatorial insertional mutagenesis.

22 September 2018

1 reference

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Failure of SCID-X1 gene therapy in older patients

22 September 2018

1 reference

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Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector

22 September 2018

1 reference

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Polyclonal chemoprotection against temozolomide in a large-animal model of drug resistance gene therapy

22 September 2018

1 reference

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Long-term clinical and molecular follow-up of large animals receiving retrovirally transduced stem and progenitor cells: no progression to clonal hematopoiesis or leukemia

22 September 2018

1 reference

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Gene therapy insertional mutagenesis insights

22 September 2018

1 reference

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In vivo selection of human hematopoietic cells in a xenograft model using combined pharmacologic and genetic manipulations

22 September 2018

1 reference

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Molecular assessment of erythroid lineage chimerism following nonmyeloablative allogeneic stem cell transplantation

22 September 2018

1 reference

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Phenotype correction of Fanconi anemia group A hematopoietic stem cells using lentiviral vector

22 September 2018

1 reference

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Lentivector-mediated clonal tracking reveals intrinsic heterogeneity in the human hematopoietic stem cell compartment and culture-induced stem cell impairment

22 September 2018

1 reference

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Reduction in hematopoietic stem cell numbers with in vivo drug selection can be partially abrogated by HOXB4 gene expression

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895696

Chimerism and cure: hematologic and pathologic correction of murine sickle cell disease.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895696

Transient in vivo selection of transduced peripheral blood cells using antifolate drug selection in rhesus macaques that received transplants with hematopoietic stem cells expressing dihydrofolate reductase vectors.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895696

A defect in hematopoietic stem cell migration explains the nonrandom X-chromosome inactivation in carriers of Wiskott-Aldrich syndrome

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895696

Successful treatment of murine beta-thalassemia using in vivo selection of genetically modified, drug-resistant hematopoietic stem cells

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895696

Gene therapy for Wiskott-Aldrich syndrome: rescue of T-cell signaling and amelioration of colitis upon transplantation of retrovirally transduced hematopoietic stem cells in mice

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895696

Gene therapy of RAG-2-/- mice: sustained correction of the immunodeficiency

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895696

Pharmacologically regulated in vivo selection in a large animal

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895696

In vivo selective expansion of gene-modified hematopoietic cells in a nonhuman primate model.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895696

Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895696

HOXB4-induced expansion of adult hematopoietic stem cells ex vivo.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895696

Multidrug resistance 1 gene transfer can confer chemoprotection to human peripheral blood progenitor cells engrafted in immunodeficient mice

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895696

HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895696

Functional requirements for phenotypic correction of murine beta-thalassemia: implications for human gene therapy

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895696

Efficient retrovirus-mediated transfer of the multidrug resistance 1 gene into autologous human long-term repopulating hematopoietic stem cells.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895696

Limiting numbers of G156A O(6)-methylguanine-DNA methyltransferase-transduced marrow progenitors repopulate nonmyeloablated mice after drug selection

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895696

Phenotypic correction of Fanconi anemia group C knockout mice.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895696

Protection of CHO cells by mutant forms of O6-alkylguanine-DNA alkyltransferase from killing by 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) plus O6-benzylguanine or O6-benzyl-8-oxoguanine

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895696

Engraftment of MDR1 and NeoR gene-transduced hematopoietic cells after breast cancer chemotherapy

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895696

The common marmoset as a target preclinical primate model for cytokine and gene therapy studies

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895696

Retroviral transfer and long-term expression of human cytidine deaminase cDNA in hematopoietic cells following transplantation in mice

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895696

Correlation of tumor O6 methylguanine-DNA methyltransferase levels with survival of malignant astrocytoma patients treated with bis-chloroethylnitrosourea: a Southwest Oncology Group study.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895696

Restoration of lymphocyte function in Janus kinase 3-deficient mice by retroviral-mediated gene transfer

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895696

Evidence that hematopoiesis may be a stochastic process in vivo

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895696

Retroviral transduction and expression of the human alkyltransferase cDNA provides nitrosourea resistance to hematopoietic cells.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895696

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895696

Spontaneous functional correction of homozygous Fanconi anaemia alleles reveals novel mechanistic basis for reverse mosaicism

21 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895696

T cell repertoire development in humans with SCID after nonablative allogeneic marrow transplantation

5 December 2018

1 reference

12 December 2020

Decreased hepcidin mRNA expression in thalassemic mice

1 reference

12 December 2020

Iron overload and desferrioxamine chelation therapy in beta-thalassemia intermedia

1 reference

12 December 2020

Iron metabolism in thalassemia intermedia

1 reference

12 December 2020

Correction of murine beta-thalassemia by partial bone marrow chimerism: selective advantage of normal erythropoiesis

1 reference

12 December 2020

Spontaneous in vivo reversion to normal of an inherited mutation in a patient with adenosine deaminase deficiency

1 reference

12 December 2020

Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell

1 reference

12 December 2020

Phlebotomy to reduce iron overload in patients cured of thalassemia by bone marrow transplantation. Italian Cooperative Group for Phlebotomy Treatment of Transplanted Thalassemia Patients

1 reference

12 December 2020

Murine leukemia induced by retroviral gene marking

1 reference

12 December 2020

Sensitization of hematopoietic stem and progenitor cells to trimetrexate using nucleoside transport inhibitors

1 reference

12 December 2020

Transduction of murine bone marrow cells with an MDR1 vector enables ex vivo stem cell expansion, but these expanded grafts cause a myeloproliferative syndrome in transplanted mice

1 reference

12 December 2020

Outcome of 69 allogeneic stem cell transplantations for Fanconi anemia using HLA-matched unrelated donors: a study on behalf of the European Group for Blood and Marrow Transplantation

1 reference

12 December 2020

1 reference

12 December 2020

Haematopoietic cell transplantation in patients with Fanconi anaemia using alternate donors: results of a total body irradiation dose escalation trial

1 reference

12 December 2020

Prolonged high-level detection of retrovirally marked hematopoietic cells in nonhuman primates after transduction of CD34+ progenitors using clinically feasible methods

1 reference

12 December 2020

Impact of donor type on outcome of bone marrow transplantation for Wiskott-Aldrich syndrome: collaborative study of the International Bone Marrow Transplant Registry and the National Marrow Donor Program

1 reference

12 December 2020

10.1182/BLOOD-2005-06-2335

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16269617%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16269617%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

1 reference