Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells. (Q33968323)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11340169%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

title

Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells (English)

1 reference

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7 November 2019

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Claudia González-Espinosa

2

1 reference

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7 November 2019

Victor Tybulewicz

5

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7 November 2019

author name string

T S Manetz

1

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7 November 2019

R Arudchandran

3

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7 November 2019

S Xirasagar

4

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7 November 2019

J Rivera

6

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7 November 2019

language of work or name

English

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publication date

1 June 2001

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Molecular and Cellular Biology

7 November 2019

published in

1 reference

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7 November 2019

volume

21

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7 November 2019

issue

11

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7 November 2019

page(s)

3763-3774

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Activated Cdc42/Rac reconstitutes Fcepsilon RI-mediated Ca2+ mobilization and degranulation in mutant RBL mast cells

7 November 2019

cites work

1 reference

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Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling

5 July 2018

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Role of basal calcium in the EGF activation of MAP kinases

5 July 2018

1 reference

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Regulatory and signaling properties of the Vav family

5 July 2018

1 reference

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Cdc42 and Rac stimulate exocytosis of secretory granules by activating the IP(3)/calcium pathway in RBL-2H3 mast cells

5 July 2018

1 reference

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The Src homology 2 domain of Vav is required for its compartmentation to the plasma membrane and activation of c-Jun NH(2)-terminal kinase 1.

5 July 2018

1 reference

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Tyrosine phosphorylation of Vav stimulates IL-6 production in mast cells by a Rac/c-Jun N-terminal kinase-dependent pathway

5 July 2018

1 reference

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SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells

5 July 2018

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5 July 2018

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Essential role of LAT in T cell development

5 July 2018

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The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways

5 July 2018

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Polyethylene glycol-mediated infection of non-permissive mammalian cells with semliki forest virus: application to signal transduction studies

5 July 2018

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Fyn and ZAP-70 are required for Vav phosphorylation in T cells stimulated by antigen-presenting cells

5 July 2018

1 reference

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Involvement of guanosine triphosphatases and phospholipase C-gamma2 in extracellular signal-regulated kinase, c-Jun NH2-terminal kinase, and p38 mitogen-activated protein kinase activation by the B cell antigen receptor.

5 July 2018

1 reference

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Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development.

5 July 2018

1 reference

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Stabilization of interleukin-2 mRNA by the c-Jun NH2-terminal kinase pathway.

5 July 2018

1 reference

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Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

Induction of exocytosis from permeabilized mast cells by the guanosine triphosphatases Rac and Cdc42.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

Thapsigargin-induced secretion is dependent on activation of a cholera toxin-sensitive and phosphatidylinositol-3-kinase-regulated phospholipase D in a mast cell line.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

Epidermal growth factor signaling and mitogenesis in Plcg1 null mouse embryonic fibroblasts

5 July 2018

1 reference

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Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of fcepsilon receptor I-mediated activation of Syk

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

Functional effects of overexpression of protein kinase C-alpha, -beta, -delta, -epsilon, and -eta in the mast cell line RBL-2H3.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

Role of the vav proto-oncogene product (Vav) in erythropoietin-mediated cell proliferation and phosphatidylinositol 3-kinase activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

Structure and function of vav

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

Tyrosine phosphorylation of the vav proto-oncogene product links FcepsilonRI to the Rac1-JNK pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development

5 July 2018

1 reference

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Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

Association of a p95 Vav-containing signaling complex with the FcepsilonRI gamma chain in the RBL-2H3 mast cell line. Evidence for a constitutive in vivo association of Vav with Grb2, Raf-1, and ERK2 in an active complex

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

Mitogen-activated protein kinase cascades and regulation of gene expression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

Calcium mobilization via sphingosine kinase in signalling by the Fc epsilon RI antigen receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

Wortmannin blocks lipid and protein kinase activities associated with PI 3-kinase and inhibits a subset of responses induced by Fc epsilon R1 cross-linking

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

Src homology 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

The vav proto-oncogene is required early in embryogenesis but not for hematopoietic development in vitro.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

Protein-tyrosine kinase p72syk in high affinity IgE receptor signaling. Identification as a component of pp72 and association with the receptor gamma chain after receptor aggregation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

A functional T-cell receptor signaling pathway is required for p95vav activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

Transphosphorylation as the mechanism by which the high-affinity receptor for IgE is phosphorylated upon aggregation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

IgE-mediated release of leukotriene C4, chondroitin sulfate E proteoglycan, beta-hexosaminidase, and histamine from cultured bone marrow-derived mouse mast cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

Antigen receptor tail clue.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

Cytokine production by mast cells and basophils

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

IgE-induced tyrosine phosphorylation of phospholipase C-gamma 1 in rat basophilic leukemia cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

Multichain immune recognition receptors: similarities in structure and signaling pathways

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

A guanine nucleotide exchange factor-independent function of Vav1 in transcriptional activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

Role of phospholipase Cgamma at fertilization and during mitosis in sea urchin eggs and embryos.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

Role of the cyclosporin-sensitive transcription factor NFAT1 in the allergic response.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

A tyrosine kinase signaling pathway accounts for the majority of phosphatidylinositol 3,4,5-trisphosphate formation in chemoattractant-stimulated human neutrophils

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87023

A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

29 October 2018

1 reference

12 December 2020

Identification of a calcium-inducible, cyclosporine sensitive element in the IFN-gamma promoter that is a potential NFAT binding site

1 reference

12 December 2020

Phosphoinositide 3-kinase regulates phospholipase Cgamma-mediated calcium signaling

1 reference

12 December 2020

Requirement for a Negative Charge at Threonine 60 of the FcRγ for Complete Activation of Syk

1 reference

12 December 2020

LAT is essential for Fc(epsilon)RI-mediated mast cell activation

1 reference

12 December 2020

Thapsigargin-induced degranulation of mast cells is dependent on transient activation of phosphatidylinositol-3 kinase

1 reference

12 December 2020

Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors

1 reference

12 December 2020

Monoclonal dinitrophenyl-specific murine IgE antibody: preparation, isolation, and characterization

1 reference

12 December 2020

Studies with a monoclonal antibody to the beta subunit of the receptor with high affinity for immunoglobulin E

1 reference

12 December 2020

Tyrosine kinase-stimulated guanine nucleotide exchange activity of Vav in T cell activation

1 reference

12 December 2020

10.1128/MCB.21.11.3763-3774.2001

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11340169%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11340169%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

1 reference