Mechanisms underlying the activation of G-protein-gated inwardly rectifying K+ (GIRK) channels by the novel anxiolytic drug, ML297. (Q33972094)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25002517%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

title

Mechanisms underlying the activation of G-protein-gated inwardly rectifying K+ (GIRK) channels by the novel anxiolytic drug, ML297 (English)

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Ezequiel Marron Fernandez de Velasco

8 March 2020

author

2

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8 March 2020

Mark J. Thomas

7

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8 March 2020

Kevin Wickman

9

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8 March 2020

author name string

Nicole Wydeven

1

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8 March 2020

Yu Du

3

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8 March 2020

Michael A Benneyworth

4

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8 March 2020

Matthew C Hearing

5

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8 March 2020

Rachel A Fischer

6

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8 March 2020

C David Weaver

8

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8 March 2020

language of work or name

English

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publication date

7 July 2014

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Proceedings of the National Academy of Sciences of the United States of America

8 March 2020

published in

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8 March 2020

volume

111

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8 March 2020

issue

29

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8 March 2020

page(s)

10755-10760

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Molecular mechanism underlying ethanol activation of G-protein-gated inwardly rectifying potassium channels

8 March 2020

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Structural elements in the Girk1 subunit that potentiate G protein-gated potassium channel activity

28 July 2018

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The complex of G protein regulator RGS9-2 and Gβ(5) controls sensitization and signaling kinetics of type 5 adenylyl cyclase in the striatum

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Crystal Structure of the Mammalian GIRK2 K+ Channel and Gating Regulation by G Proteins, PIP2, and Sodium

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Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q.

28 July 2018

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28 July 2018

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Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease.

28 July 2018

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Inwardly rectifying potassium channels: their structure, function, and physiological roles

28 July 2018

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A discrete alcohol pocket involved in GIRK channel activation

28 July 2018

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The c-terminus of GRK3 indicates rapid dissociation of G protein heterotrimers

28 July 2018

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Voltage-sensing phosphatase: actions and potentials

28 July 2018

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Behavioral characterization of mice lacking GIRK/Kir3 channel subunits.

28 July 2018

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G protein-activated inwardly rectifying potassium channels as potential therapeutic targets

28 July 2018

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GIRK2 deficient mice. Evidence for hyperactivity and reduced anxiety

28 July 2018

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G protein-gated inwardly rectifying potassium channels are targets for volatile anesthetics.

28 July 2018

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Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3

28 July 2018

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Ethanol opens G-protein-activated inwardly rectifying K+ channels

28 July 2018

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G-protein-coupled inwardly rectifying potassium channels are targets of alcohol action

28 July 2018

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Molecular determinants for sodium-dependent activation of G protein-gated K+ channels

28 July 2018

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Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma

28 July 2018

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Activation of the atrial KACh channel by the betagamma subunits of G proteins or intracellular Na+ ions depends on the presence of phosphatidylinositol phosphates

28 July 2018

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28 July 2018

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Control of channel activity through a unique amino acid residue of a G protein-gated inwardly rectifying K+ channel subunit

28 July 2018

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Heteromultimerization of G-protein-gated inwardly rectifying K+ channel proteins GIRK1 and GIRK2 and their altered expression in weaver brain

28 July 2018

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28 July 2018

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28 July 2018

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Differential effects of general anesthetics on G protein-coupled inwardly rectifying and other potassium channels

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21 January 2018

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21 January 2018

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Identification of structural elements involved in G protein gating of the GIRK1 potassium channel

21 January 2018

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ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice

21 January 2018

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Contribution of Kir3.1, Kir3.2A and Kir3.2C subunits to native G protein‐gated inwardly rectifying potassium currents in cultured hippocampal neurons

21 January 2018

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Activation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactions.

21 January 2018

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A unique P-region residue is required for slow voltage-dependent gating of a G protein-activated inward rectifier K+ channel expressed in Xenopus oocytes.

21 January 2018

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Reduced ethanol-induced conditioned taste aversion and conditioned place preference in GIRK2 null mutant mice

21 January 2018

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Bi-directional effects of GABA(B) receptor agonists on the mesolimbic dopamine system

21 January 2018

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21 January 2018

Identifiers

DOI

10.1073/PNAS.1405190111

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25002517%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

0 references

1 reference

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8 March 2020

PubMed publication ID

25002517

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25002517%20AND%20SRC:MED&resulttype=core&format=json