Impact on malaria parasite multiplication rates in infected volunteers of the protein-in-adjuvant vaccine AMA1-C1/Alhydrogel+CPG 7909. (Q33974904)

30 July 2017

Impact on malaria parasite multiplication rates in infected volunteers of the protein-in-adjuvant vaccine AMA1-C1/Alhydrogel+CPG 7909. (English)

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Katharine A Collins

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Fenella D Halstead

Fenella D Halstead

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Nick J Edwards

Nick J Edwards

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Alexander D Douglas

Alexander D Douglas

4

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Katie J. Ewer

Katie J Ewer

3

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Patrick Lillie

Patrick J Lillie

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Simon J. Draper

Simon J Draper

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Michael P. Fay

Michael P Fay

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Adrian V. S. Hill

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Adrian V S Hill

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Kazutoyo Miura

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Carole A Long

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Ruth D Ellis

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Alison M Lawrie

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Susanne H Sheehy

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Sean C Elias

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Ian D Poulton

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Angela Hunt-Cooke

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Fiona M Thompson

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Daming Zhu

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Kelly Rausch

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Joan Aebig

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Christopher J A Duncan

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David W Porter

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Ros Rowland

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Yimin Wu

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Laura B Martin

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Charles F Anderson

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language of work or name

English

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publication date

22 July 2011

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6

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7

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e22271

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Creative Commons CC0 License

30 July 2017

start time

22 July 2011

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April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

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Clinical protection from falciparum malaria correlates with neutrophil respiratory bursts induced by merozoites opsonized with human serum antibodies

5 July 2018

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5 July 2018

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High antibody titer against apical membrane antigen-1 is required to protect against malaria in the Aotus model

5 July 2018

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Growth-inhibitory antibodies are not necessary for protective immunity to malaria infection

5 July 2018

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5 July 2018

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A randomized and controlled Phase 1 study of the safety and immunogenicity of the AMA1-C1/Alhydrogel + CPG 7909 vaccine for Plasmodium falciparum malaria in semi-immune Malian adults

5 July 2018

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A distinct peripheral blood monocyte phenotype is associated with parasite inhibitory activity in acute uncomplicated Plasmodium falciparum malaria

5 July 2018

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Multiple functions of human T cells generated by experimental malaria challenge

5 July 2018

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Inhibitory antibodies specific for the 19-kilodalton fragment of merozoite surface protein 1 do not correlate with delayed appearance of infection with Plasmodium falciparum in semi-immune individuals in Vietnam

5 July 2018

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Anti-apical-membrane-antigen-1 antibody is more effective than anti-42-kilodalton-merozoite-surface-protein-1 antibody in inhibiting plasmodium falciparum growth, as determined by the in vitro growth inhibition assay

5 July 2018

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A randomized controlled phase 2 trial of the blood stage AMA1-C1/Alhydrogel malaria vaccine in children in Mali

5 July 2018

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A Phase 1 study of the blood-stage malaria vaccine candidate AMA1-C1/Alhydrogel with CPG 7909, using two different formulations and dosing intervals

5 July 2018

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Phase 1/2a study of the malaria vaccine candidate apical membrane antigen-1 (AMA-1) administered in adjuvant system AS01B or AS02A.

5 July 2018

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Cell-mediated immunity elicited by the blood stage malaria vaccine apical membrane antigen 1 in Malian adults: results of a Phase I randomized trial

5 July 2018

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The TLR9 ligand CpG promotes the acquisition of Plasmodium falciparum-specific memory B cells in malaria-naive individuals

5 July 2018

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Safety and immunogenicity of a recombinant Plasmodium falciparum AMA1 malaria vaccine adjuvanted with Alhydrogel, Montanide ISA 720 or AS02.

5 July 2018

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Antibody-mediated growth inhibition of Plasmodium falciparum: relationship to age and protection from parasitemia in Kenyan children and adults

5 July 2018

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Phase 1 trial of AMA1-C1/Alhydrogel plus CPG 7909: an asexual blood-stage vaccine for Plasmodium falciparum malaria

5 July 2018

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Blood-stage challenge for malaria vaccine efficacy trials: a pilot study with discussion of safety and potential value.

5 July 2018

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Phase 1 study of a combination AMA1 blood stage malaria vaccine in Malian children

5 July 2018

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Evidence of blood stage efficacy with a virosomal malaria vaccine in a phase IIa clinical trial

5 July 2018

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Development and characterization of a standardized ELISA including a reference serum on each plate to detect antibodies induced by experimental malaria vaccines

5 July 2018

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5 July 2018

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Immunity to recombinant plasmodium falciparum merozoite surface protein 1 (MSP1): protection in Aotus nancymai monkeys strongly correlates with anti-MSP1 antibody titer and in vitro parasite-inhibitory activity

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Upregulation of TGF-beta, FOXP3, and CD4+CD25+ regulatory T cells correlates with more rapid parasite growth in human malaria infection

5 July 2018

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Phase 1 clinical trial of apical membrane antigen 1: an asexual blood-stage vaccine for Plasmodium falciparum malaria

5 July 2018

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5 July 2018

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5 July 2018

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High diversity and rapid changeover of expressed var genes during the acute phase of Plasmodium falciparum infections in human volunteers

5 July 2018

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5 July 2018

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Effect of vaccination with 3 recombinant asexual-stage malaria antigens on initial growth rates of Plasmodium falciparum in non-immune volunteers

5 July 2018

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Measurement of Plasmodium falciparum growth rates in vivo: a test of malaria vaccines

5 July 2018

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Antibodies that protect humans against Plasmodium falciparum blood stages do not on their own inhibit parasite growth and invasion in vitro, but act in cooperation with monocytes

5 July 2018

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Malaria. Did they really say ... eradication?

5 July 2018

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The potential role of vaccines in the elimination of falciparum malaria and the eventual eradication of malaria.

21 January 2018

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Report of a consultation on the optimization of clinical challenge trials for evaluation of candidate blood stage malaria vaccines, 18-19 March 2009, Bethesda, MD, USA.

21 January 2018

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Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans

21 January 2018

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Evidence that invasion-inhibitory antibodies specific for the 19-kDa fragment of merozoite surface protein-1 (MSP-1 19) can play a protective role against blood-stage Plasmodium falciparum infection in individuals in a malaria endemic area of Africa

21 January 2018

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Quantitative real-time polymerase chain reaction for malaria diagnosis and its use in malaria vaccine clinical trials.

21 January 2018

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Testing vaccines in human experimental malaria: statistical analysis of parasitemia measured by a quantitative real-time polymerase chain reaction

29 October 2018

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10.1371/JOURNAL.PONE.0022271

29 October 2018

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DOI

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30 July 2017

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30 July 2017

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