Future antidepressants: what is in the pipeline and what is missing? (Q33980902)

30 July 2017

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title

Future antidepressants: what is in the pipeline and what is missing? (English)

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30 July 2017

Fokko J Bosker

1

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30 July 2017

Ben H C Westerink

2

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30 July 2017

Thomas I F H Cremers

3

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30 July 2017

Marjolein Gerrits

4

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30 July 2017

Marieke G C van der Hart

5

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30 July 2017

Sjoukje D Kuipers

6

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30 July 2017

Gieta van der Pompe

7

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30 July 2017

Gert J ter Horst

8

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30 July 2017

Johan A den Boer

9

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30 July 2017

Jakob Korf

10

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30 July 2017

1 January 2004

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30 July 2017

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30 July 2017

18

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30 July 2017

11

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30 July 2017

705-732

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https://scigraph.springernature.com/pub.10.2165/00023210-200418110-00002

30 July 2017

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Pindolol and mianserin augment the antidepressant activity of fluoxetine in hospitalized major depressed patients, including those with treatment resistance.

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Slow wave sleep in humans: role of 5-HT2A and 5-HT2C receptors.

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Duloxetine in the long-term treatment of major depressive disorder

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Pharmacological profile of the novel antidepressant 4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno-[2,3-d]pyrimidine monohydrate hydrochloride

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Selective blockade of neurokinin-2 receptors produces antidepressant-like effects associated with reduced corticotropin-releasing factor function

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Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states

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A double-blind, placebo-controlled trial of the safety and efficacy of selegiline transdermal system without dietary restrictions in patients with major depressive disorder.

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Buspirone is an effective augmenting agent of serotonin selective re-uptake inhibitors in severe treatment-refractory depression

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Cardiovascular and symptomatic reduction effects of alprazolam and imipramine in patients with panic disorder: results of a double-blind, placebo-controlled trial

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Neuropharmacological profile of a selective sigma ligand, igmesine: a potential antidepressant

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Adrenocorticotropin/alpha-melanocyte-stimulating hormone (ACTH/MSH)-like peptides modulate adenylate cyclase activity in rat brain slices: evidence for an ACTH/MSH receptor-coupled mechanism.

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12 December 2020

The effects of nefazodone on sleep architecture in depression

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12 December 2020

Neurokinin-1 receptors are decreased in major depressive disorder.

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12 December 2020

Selective serotonin reuptake inhibitors versus tricyclic antidepressants: a meta-analysis of efficacy and tolerability.

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12 December 2020

Catecholaminergic control of alpha-melanocyte-stimulating hormone (alpha MSH) release by frog neurointermediate lobe in vitro: evidence for direct stimulation of alpha MSH release by thyrotropin-releasing hormone.

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12 December 2020

The catecholamine hypothesis of affective disorders: a review of supporting evidence

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12 December 2020

Therapeutic potential of histamine H3 receptor agonists and antagonists.

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Psychopharmacological treatment of social phobia; a double blind placebo controlled study with fluvoxamine

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12 December 2020

Selective serotonin reuptake inhibitors: meta-analysis of discontinuation rates.

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12 December 2020

Enhancing neuronal plasticity and cellular resilience to develop novel, improved therapeutics for Difficult-to-Treat depression

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Depression: the case for a monoamine deficiency.

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12 December 2020

Efficacy of estradiol for the treatment of depressive disorders in perimenopausal women: a double-blind, randomized, placebo-controlled trial

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12 December 2020

Antidepressant-like activity of S 20098 (agomelatine) in the forced swimming test in rodents: involvement of melatonin and serotonin receptors.

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12 December 2020

Considering depression as a consequence of activation of the inflammatory response system

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12 December 2020

Duloxetine for the treatment of major depressive disorder.

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12 December 2020

Effects of histamine H3 receptor ligands in experimental models of anxiety and depression.

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12 December 2020

Downregulation of BDNF mRNA in the hippocampal dentate gyrus after re-exposure to cues previously associated with footshock.

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12 December 2020

Citalopram in doses of 20-60 mg is effective in depression relapse prevention: a placebo-controlled 6 month study.

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12 December 2020

Synthesis and SAR of adatanserin: novel adamantyl aryl- and heteroarylpiperazines with dual serotonin 5-HT(1A) and 5-HT(2) activity as potential anxiolytic and antidepressant agents

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12 December 2020

Determination of the dose of agomelatine, a melatoninergic agonist and selective 5-HT(2C) antagonist, in the treatment of major depressive disorder: a placebo-controlled dose range study

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12 December 2020

Regulation of cellular plasticity cascades in the pathophysiology and treatment of mood disorders: role of the glutamatergic system

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12 December 2020

Substance P serum levels are increased in major depression: preliminary results

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12 December 2020

A single-site, double-blind, placebo-controlled, dose-ranging study of YKP10A--a putative, new antidepressant

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12 December 2020

Mirtazapine, yohimbine or olanzapine augmentation therapy for serotonin reuptake-associated female sexual dysfunction: a randomized, placebo controlled trial

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12 December 2020

A double-blind trial of low- and high-dose ranges of gepirone-ER compared with placebo in the treatment of depressed outpatients

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12 December 2020

High-dose selegiline in treatment-resistant older depressive patients.

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12 December 2020

An open label trial of C-1073 (mifepristone) for psychotic major depression

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12 December 2020

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12 December 2020

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12 December 2020

Transdermal selegiline in major depression: a double-blind, placebo-controlled, parallel-group study in outpatients

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12 December 2020

An open-label study of duloxetine hydrochloride, a mixed serotonin and noradrenaline reuptake inhibitor, in patients with DSM-III-R major depressive disorder. Lilly Duloxetine Depression Study Group.

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12 December 2020

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12 December 2020

Estrogen desensitizes 5-HT1A receptors and reduces levels of Gz, Gi1 and Gi3 proteins in the hypothalamus

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12 December 2020

Future therapeutic targets in mood disorders: the glucocorticoid receptor

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

Gepirone as a 5-HT1A agonist in the treatment of major depression

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12 December 2020

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12 December 2020

Hormonal treatment and psychological function during the menopausal transition: an evaluation of the effects of conjugated estrogens/cyclic medroxyprogesterone acetate.

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12 December 2020

5-HT1A agonist activity of pindolol: reversal of the inhibitory effects on cell firing in the dorsal raphe nucleus but not in the hippocampus by WAY-100,635.

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12 December 2020

Antidepressant-like effects of the subtype-selective nicotinic acetylcholine receptor agonist, SIB-1508Y, in the learned helplessness rat model of depression

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12 December 2020

Distribution of estrogen receptor beta immunoreactivity in the rat central nervous system

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12 December 2020

5-HT(1A) agonist potential of pindolol: electrophysiologic studies in the dorsal raphe nucleus and hippocampus

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12 December 2020

The effects of tibolone on mood and libido.

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12 December 2020

The Molecular Pharmacology of SERMs

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12 December 2020

Gonadal steroid hormone receptors and sex differences in the hypothalamo-pituitary-adrenal axis

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12 December 2020

Are SSRIs better than TCAs? Comparison of SSRIs and TCAs: a meta-analysis

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12 December 2020

Neurobiology of serotonin in depression and suicide.

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12 December 2020

Duloxetine 60 mg once daily dosing versus placebo in the acute treatment of major depression

1 reference

12 December 2020

Serotonin syndrome after challenge with the 5-HT agonist meta-chlorophenylpiperazine

1 reference

12 December 2020

Effect of a serotonin and noradrenaline uptake inhibitor in panic disorder; a double-blind comparative study with fluvoxamine and maprotiline

1 reference

12 December 2020

Substance P Acts through local circuits within the rat dorsal raphe nucleus to alter serotonergic neuronal activity.

1 reference

12 December 2020

Efficacy and tolerability of venlafaxine compared with selective serotonin reuptake inhibitors and other antidepressants: a meta-analysis

1 reference

12 December 2020

History and evolution of the monoamine hypothesis of depression.

1 reference

12 December 2020

Possible augmentation of antidepressant response by buspirone

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12 December 2020

5-HT and antidepressants: new views from microdialysis studies.

1 reference

12 December 2020

Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus.

1 reference

12 December 2020

A comparison of adinazolam and desipramine in the treatment of major depression.

1 reference

12 December 2020

Comparison of compliance between serotonin reuptake inhibitors and tricyclic antidepressants: a meta-analysis

1 reference

12 December 2020

The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons

1 reference

12 December 2020

Preliminary observations on differing psychological effects of conjugated and esterified estrogen treatments

1 reference

12 December 2020

The functional neuroanatomy of the placebo effect

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12 December 2020

Neuroendocrine aspects of hypercortisolism in major depression

1 reference

12 December 2020

Evidence that cyproterone acetate improves psychological symptoms and enhances the activity of the dopaminergic system in postmenopause

1 reference

12 December 2020

The treatment of chronic depression, part 1: study design and rationale for evaluating the comparative efficacy of sertraline and imipramine as acute, crossover, continuation, and maintenance phase therapies.

1 reference

12 December 2020

Antidepressant-like responses to the combined sigma and 5-HT1A receptor agonist OPC-14523.

1 reference

12 December 2020

F 11440, a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential.

1 reference

12 December 2020

Antidepressant-like effect by postsynaptic 5-HT1A receptor activation in mice

1 reference

12 December 2020

Estrogen replacement therapy in the treatment of major depressive disorder in perimenopausal women.

1 reference

12 December 2020

A double-blind study of long-term treatment with sertraline or fluvoxamine for prevention of highly recurrent unipolar depression

1 reference

12 December 2020

Partial role of 5-HT2 and 5-HT3 receptors in the activity of antidepressants in the mouse forced swimming test

1 reference

12 December 2020

An open pilot study combining risperidone and a selective serotonin reuptake inhibitor as initial antidepressant therapy.

1 reference

12 December 2020

GABA and affective disorders.

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12 December 2020

SSRIS versus tricyclic antidepressants in depressed inpatients: a meta-analysis of efficacy and tolerability

1 reference

12 December 2020

cAMP-dependent phosphorylation system after short and long-term administration of moclobemide

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12 December 2020

Antidepressant treatments in the 21st century

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12 December 2020

Effects of chronic 17beta-estradiol treatment on the serotonin 5-HT(1A) receptor mRNA and binding levels in the rat brain

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12 December 2020

Gender differences in regional cerebral blood flow during transient self-induced sadness or happiness.

1 reference

12 December 2020

MIF-1 potentiates the action of tricyclic antidepressants in an animal model of depression

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12 December 2020

Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase.

1 reference

12 December 2020

Smoking and major depression. A causal analysis

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12 December 2020

Depression and self-medication with nicotine: the modifying influence of the dopamine D4 receptor gene

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12 December 2020

Symptom profiles of biological markers in depression: a multivariate study.

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12 December 2020

MIF-1 is active in a chronic stress animal model of depression

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12 December 2020

Indole-pyruvic acid, a tryptophan ketoanalogue, antagonizes the endocrine but not the behavioral effects of repeated stress in a model of depression.

1 reference

12 December 2020

Double-blind, placebo-controlled study of INN 00835 (netamiftide) in the treatment of outpatients with major depression.

1 reference

12 December 2020

Tryptophan as a link between psychopathology and somatic states

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12 December 2020

Association between serotonin transporter gene promoter polymorphism (5HTTLPR) and behavioral responses to tryptophan depletion in healthy women with and without family history of depression

1 reference

12 December 2020

Estrogen: physiology, pharmacology, and formulations for replacement therapy.

1 reference

12 December 2020

Prasterone (DHEA) and mania.

1 reference

12 December 2020

A functional anatomical study of unipolar depression.

1 reference

12 December 2020

Antidepressant effects of ketamine in depressed patients

1 reference

12 December 2020

Decreased serum brain-derived neurotrophic factor levels in major depressed patients.

1 reference

12 December 2020

Sigma 1 receptor subtype is involved in the relief of behavioral despair in the mouse forced swimming test

1 reference

12 December 2020

20mg transdermal selegiline daily may be effective and well tolerated in adults with major depression

1 reference

12 December 2020

Swim Stress Increases the Potency of Glycine at the N-Methyl-d-Aspartate Receptor Complex

1 reference

12 December 2020

5-Hydroxytryptamine1A receptor occupancy by novel full antagonist 2-[4-[4-(7-chloro-2,3-dihydro-1,4-benzdioxyn-5-yl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3-(2H)-one-1,1-dioxide: a[11C][O-methyl-3H]-N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N

1 reference

12 December 2020

Fluvoxamine treatment of obsessive-compulsive disorder

1 reference

12 December 2020

Augmentation strategies: focus on anxiolytics

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12 December 2020

Sustained blockade of neurokinin-1 receptors enhances serotonin neurotransmission

1 reference

12 December 2020

Antidepressant drug discovery in the postgenomic era.

1 reference

12 December 2020

Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial

1 reference

12 December 2020

cAMP response element-binding protein is essential for the upregulation of brain-derived neurotrophic factor transcription, but not the behavioral or endocrine responses to antidepressant drugs.

1 reference

12 December 2020

Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial

1 reference

12 December 2020

Effects of psychotropic drugs on the behavior and neurochemistry of olfactory bulbectomized rats

1 reference

12 December 2020

Estrogen-serotonin interactions: implications for affective regulation.

1 reference

12 December 2020

Glutamate and depression: clinical and preclinical studies

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12 December 2020

Antidepressant profile in rodents of SR 58611A, a new selective agonist for atypical beta-adrenoceptors

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12 December 2020

cAMP response element-mediated gene transcription is upregulated by chronic antidepressant treatment.

1 reference

12 December 2020

Substance P (NK1) receptors in the cingulate cortex in unipolar and bipolar mood disorder and schizophrenia

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12 December 2020

Ultrasonic vocalizations in rat pups: effects of serotonergic ligands

1 reference

12 December 2020

H3-receptors control histamine release in human brain

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12 December 2020

Citalopram in depression--meta-analysis of intended and unintended effects

1 reference

12 December 2020

A controlled trial of adinazolam versus desipramine in geriatric depression

1 reference

12 December 2020

Antiglucocorticoid therapies in major depression: a review

1 reference

12 December 2020

Raloxifene and estrogen effects on quality of life in healthy postmenopausal women: a placebo-controlled randomized trial

1 reference

12 December 2020

Production and actions of estrogens

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12 December 2020

CNS drugs III: psychotherapeutics.

1 reference

12 December 2020

Antidepressant effects of nicotine in an animal model of depression.

1 reference

12 December 2020

Care utilization and outcome of DSM-III-R major depression in the general population. Results from the Netherlands Mental Health Survey and Incidence Study (NEMESIS)

1 reference

12 December 2020

Influence of the 5-HT2C receptor antagonist, SB-242084, in tests of anxiety

1 reference

12 December 2020

Effects of stress on neurotrophic factor expression in the rat brain.

1 reference

12 December 2020

Metyrapone displays antidepressant-like properties in preclinical paradigms.

1 reference

12 December 2020

Neurotrophins and depression

1 reference

12 December 2020

Fluoxetine treatment of obsessive-compulsive disorder

1 reference

12 December 2020

Stress and cognition: are corticosteroids good or bad guys?

1 reference

12 December 2020

Tissue-specific estrogenic response and molecular mechanisms

1 reference

12 December 2020

Expression of the cAMP response element binding protein (CREB) in hippocampus produces an antidepressant effect.

1 reference

12 December 2020

cAMP signaling pathway in depressed patients with psychotic features

1 reference

12 December 2020

Inactivation of 5-HT(2C) receptors potentiates consequences of serotonin reuptake blockade

1 reference

12 December 2020

Comparison of adinazolam, amitriptyline, and diazepam in endogenous depressive inpatients exhibiting DST nonsuppression or abnormal contingent negative variation.

1 reference

12 December 2020

HRT and SERMs: the good, the bad...and the lovely?

1 reference

12 December 2020

Depression in women: implications for health care research

1 reference

12 December 2020

Reduced activation and expression of ERK1/2 MAP kinase in the post-mortem brain of depressed suicide subjects

1 reference

12 December 2020

Denosologization of biological psychiatry or the specificity of 5-HT disturbances in psychiatric disorders

1 reference

12 December 2020

Depresssion--emerging insights from neurobiology

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12 December 2020

Paroxetine in the treatment of melancholia and severe depression

1 reference

12 December 2020

Alpha 2-adrenoceptors in the brain of suicide victims: increased receptor density associated with major depression.

1 reference

12 December 2020

Discovery of the antidepressant and anti-emetic efficacy of substance P receptor (NK1) antagonists

1 reference

12 December 2020

Neurobiology of depression

1 reference

12 December 2020

A randomized, double-blind, placebo-controlled trial of buspirone in combination with an SSRI in patients with treatment-refractory depression

1 reference

12 December 2020

Estrogen therapy for depression in postmenopausal women

1 reference

12 December 2020

Treatment of the serotonin syndrome with cyproheptadine.

1 reference

12 December 2020

Smoking, smoking cessation, and major depression

1 reference

12 December 2020

Chronic administration of the 5-HT1A receptor agonist 8-OH-DPAT differentially desensitizes 5-HT1A autoreceptors of the dorsal and median raphe nuclei.

1 reference

12 December 2020

Glucose metabolism in the amygdala in depression: relationship to diagnostic subtype and plasma cortisol levels

1 reference

12 December 2020

Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication

1 reference

12 December 2020

Functional genomics and depression research. Beyond the monoamine hypothesis

1 reference

12 December 2020

A Potent Nonpeptide Antagonist of the Substance P (NK 1 ) Receptor

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12 December 2020

Augmentation with a 5-HT(1A), but not a 5-HT(1B) receptor antagonist critically depends on the dose of citalopram

1 reference

12 December 2020

Cellular mechanisms in the vulnerability to depression and response to antidepressants

1 reference

12 December 2020

Gepirone in the treatment of major depression

1 reference

12 December 2020

Increased depressive ratings in patients with hepatitis C receiving interferon-alpha-based immunotherapy are related to interferon-alpha-induced changes in the serotonergic system

1 reference

12 December 2020

Duloxetine in the treatment of depression: a double-blind placebo-controlled comparison with paroxetine

1 reference

12 December 2020

Selective chronic stress-induced in vivo ERK1/2 hyperphosphorylation in medial prefrontocortical dendrites: implications for stress-related cortical pathology?

1 reference

12 December 2020

Rapid reversal of psychotic depression using mifepristone

1 reference

12 December 2020

Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated

1 reference

12 December 2020

Infliximab improves quality of life in patients with Crohn's disease

1 reference

12 December 2020

Modifications of the serotonin system by antidepressant treatments: implications for the therapeutic response in major depression

1 reference

12 December 2020

Neuropeptides and the hypothalamic-pituitary-adrenocortical (HPA) system: review of recent research strategies in depression

1 reference

12 December 2020

The NK1-receptor antagonist NKP608 has an antidepressant-like effect in the chronic mild stress model of depression in rats

1 reference

12 December 2020

Finding the Intracellular Signaling Pathways Affected by Mood Disorder Treatments

1 reference

12 December 2020

Adinazolam, diazepam, imipramine, and placebo in major depressive disorder: a controlled study.

1 reference

12 December 2020

Blockade of substance P (neurokinin 1) receptors enhances extracellular serotonin when combined with a selective serotonin reuptake inhibitor: an in vivo microdialysis study in mice

1 reference

12 December 2020

Cyclic AMP-dependent protein kinase in subtypes of major depression and normal volunteers

1 reference

12 December 2020

Randomised controlled study of sleep after nefazodone or paroxetine treatment in out-patients with depression

1 reference

12 December 2020

Modulation of long-term potentiation in CA1 region of mouse hippocampal brain slices by GABAA receptor benzodiazepine site ligands.

1 reference

12 December 2020

Abnormal ACTH and cortisol responses to ovine corticotropin releasing factor in patients with primary affective disorder.

1 reference

12 December 2020

Estrogen, serotonin, and mood disturbance: where is the therapeutic bridge?

1 reference

12 December 2020

The treatment of chronic depression, part 2: a double-blind, randomized trial of sertraline and imipramine.

1 reference

12 December 2020

Corticotropin releasing hormone: relevance to normal physiology and to the pathophysiology and differential diagnosis of hypercortisolism and adrenal insufficiency

1 reference

12 December 2020

Anxiolytic-like effects of the prototypical metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine in rodents.

1 reference

12 December 2020

Changes in the immune system in depression and dementia: causal or co-incidental effects?

1 reference

12 December 2020

Synergistic effects of olanzapine and other antipsychotic agents in combination with fluoxetine on norepinephrine and dopamine release in rat prefrontal cortex

1 reference

12 December 2020

Fluoxetine, but not other selective serotonin uptake inhibitors, increases norepinephrine and dopamine extracellular levels in prefrontal cortex

1 reference

12 December 2020

Duloxetine in the treatment of major depressive disorder: a double-blind clinical trial.

1 reference

12 December 2020

Physiological investigation of a unique extract of black cohosh (Cimicifugae racemosae rhizoma): a 6-month clinical study demonstrates no systemic estrogenic effect

1 reference

12 December 2020

Paroxetine is better than placebo in relapse prevention and the prophylaxis of recurrent depression

1 reference

12 December 2020

Duloxetine, 60 mg once daily, for major depressive disorder: a randomized double-blind placebo-controlled trial

1 reference

12 December 2020

Is depression an adaptation?

1 reference

12 December 2020

Improvement in major depression after low subcutaneous doses of MIF-1.

1 reference

12 December 2020

Neuroendocrine responses to inhibitors of steroid biosynthesis in patients with major depression resistant to antidepressant therapy.

1 reference

12 December 2020

Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol.

1 reference

12 December 2020

Impact of substance P receptor antagonism on the serotonin and norepinephrine systems: relevance to the antidepressant/anxiolytic response

1 reference

12 December 2020

Increased occipital cortex GABA concentrations in depressed patients after therapy with selective serotonin reuptake inhibitors

1 reference

12 December 2020

Cholinergic dysfunction in depression

1 reference

12 December 2020

Regulation of tyrosine hydroxylase gene transcription by the cAMP-signaling pathway: involvement of multiple transcription factors

1 reference

12 December 2020

Oestrogen receptors, receptor variants and oestrogen actions in the hypothalamic-pituitary axis

1 reference

12 December 2020

Novel benzodioxan derivative, 5-[3-[((2S)-1,4-benzodioxan-2-ylmethyl) amino]propoxy]-1,3-benzodioxole HCl (MKC-242), with anxiolytic-like and antidepressant-like effects in animal models

1 reference

12 December 2020

Augmentation with buspirone: a review

1 reference

12 December 2020

Gepirone treatment of atypical depression: preliminary evidence of serotonergic involvement.

1 reference

12 December 2020

Adenosine A2A receptor antagonists are potential antidepressants: evidence based on pharmacology and A2A receptor knockout mice

1 reference

12 December 2020

Substance P receptor antagonist and clomipramine prevent stress-induced alterations in cerebral metabolites, cytogenesis in the dentate gyrus and hippocampal volume.

1 reference

12 December 2020

Comparative effects of nefazodone and fluoxetine on sleep in outpatients with major depressive disorder.

1 reference

12 December 2020

10.2165/00023210-200418110-00002

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DOI

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Dimensions Publication ID

30 July 2017

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