Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: chemistry, biological evaluations, and therapeutic prospects. (Q33990607)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16216010%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

review article

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title

Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: chemistry, biological evaluations, and therapeutic prospects (English)

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7 January 2020

1

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7 January 2020

author name string

Daniel Dauzonne

series ordinal

2

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publication date

1 January 2006

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Medicinal Research Reviews

7 January 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16216010%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

volume

26

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7 January 2020

issue

1

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7 January 2020

page(s)

88-130

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Myb and Ets proteins cooperate to transactivate an early myeloid gene

7 January 2020

cites work

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An enhancer with cell-type dependent activity is located between the myeloid and epithelial aminopeptidase N (CD 13) promoters

21 January 2018

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c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation

21 January 2018

1 reference

Effects of peptidase inhibition on angiotensin receptor agonist and antagonist potency in rabbit isolated thoracic aorta

21 January 2018

1 reference

Alanyl aminopeptidase from human seminal plasma: purification, characterization, and immunohistochemical localization in the male genital tract

21 January 2018

1 reference

Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances

21 January 2018

1 reference

Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation

21 January 2018

1 reference

Cell signaling pathways altered by natural chemopreventive agents

21 January 2018

1 reference

Effect of curcumin on radiation-impaired healing of excisional wounds in mice

21 January 2018

1 reference

Zinc metallopeptidases: active site structure and design of selective and mixed inhibitors: new approaches in the search for analgesics and anti-hypertensives

21 January 2018

1 reference

Expression of aminopeptidase N on human choriocarcinoma cells and cell growth suppression by the inhibition of aminopeptidase N activity

21 January 2018

1 reference

Leukemic cell-surface CD13/aminopeptidase N and resistance to apoptosis mediated by endothelial cells

21 January 2018

1 reference

Betulinic acid inhibits growth factor-induced in vitro angiogenesis via the modulation of mitochondrial function in endothelial cells.

21 January 2018

1 reference

Inhibitory effect of rikkunshi-to, a traditional Chinese herbal prescription, on tumor promotion in two-stage carcinogenesis in mouse skin.

21 January 2018

1 reference

Betulinic acid suppresses carcinogen-induced NF-kappa B activation through inhibition of I kappa B alpha kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9.

21 January 2018

1 reference

Characterization of aminopeptidase N from the brush border membrane of the larvae midgut of silkworm, Bombyx mori as a zinc enzyme

21 January 2018

1 reference

The metabolism of neuropeptides. Phase separation of synaptic membrane preparations with Triton X-114 reveals the presence of aminopeptidase N.

21 January 2018

1 reference

The aminopeptidase activity in the human T-cell lymphoma line (Jurkat) is not at the cell surface and is not aminopeptidase N (CD-13).

21 January 2018

1 reference

Purification by affinity chromatography using amastatin and properties of aminopeptidase A from pig kidney

21 January 2018

1 reference

Proteins of the kidney microvillar membrane. Enzymic and molecular properties of aminopeptidase W

21 January 2018

1 reference

Bestatin results in pathophysiological changes similar to preeclampsia in rats via induction of placental apoptosis

21 January 2018

1 reference

12 December 2020

Inhibition of zinc metallopeptidases by flavonoids and related phenolic compounds: structure-activity relationships

1 reference

12 December 2020

CD13/aminopeptidase N-induced lymphocyte involvement in inflamed joints of patients with rheumatoid arthritis

1 reference

12 December 2020

Inhibitory action of spinorphin, an endogenous regulator of enkephalin-degrading enzymes, on carrageenan-induced polymorphonuclear neutrophil accumulation in mouse air-pouches

1 reference

12 December 2020

The slow, tight binding of bestatin and amastatin to aminopeptidases

1 reference

12 December 2020

Enhancement by ubenimex (bestatin) of host resistance to Candida albicans infection

1 reference

12 December 2020

Role of CD13/aminopeptidase N in rat lymphocytic alveolitis caused by thoracic irradiation

1 reference

12 December 2020

Preparation of novel specific aminopeptidase inhibitors with a cyclic imide skeleton

1 reference

12 December 2020

Alpha-diketone and alpha-keto ester derivatives of N-protected amino acids and peptides as novel inhibitors of cysteine and serine proteinases

1 reference

12 December 2020

Analgesic effect of actinonin, a new potent inhibitor of multiple enkephalin degrading enzymes.

1 reference

12 December 2020

Expression of aminopeptidase N/CD13 in tumour-infiltrating lymphocytes from human renal cell carcinoma

1 reference

12 December 2020

Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor

1 reference

12 December 2020

Enhancement of Antibody Formation against Herpes Simplex Virus in Mice by the T-Cell Mitogen Bestatin

1 reference

12 December 2020

Practical synthesis of (2s,3s)-3-amino-2-hydroxy-4-phenylbutyric acid, a key component of HIV protease inhibitors

1 reference

12 December 2020

Aminopeptidase N regulated by zinc in human prostate participates in tumor cell invasion

1 reference

12 December 2020

Phebestin, a new inhibitor of aminopeptidase N, produced by Streptomyces sp. MJ716-m3

1 reference

12 December 2020

Aminopeptidase N is a major receptor for the entero-pathogenic coronavirus TGEV

1 reference

12 December 2020

Enhancement of interleukin 1 and interleukin 2 releases by ubenimex

1 reference

12 December 2020

Aminopeptidase N-mediated signal transduction and inhibition of proliferation of human myeloid cells.

1 reference

12 December 2020

Repeated systemic administration of the mixed inhibitor of enkephalin-degrading enzymes, RB101, does not induce either antinociceptive tolerance or cross-tolerance with morphine

1 reference

12 December 2020

Inhibition of metallopeptidases by flavonoids and related compounds.

1 reference

12 December 2020

Regional distribution of enkephalinase in the rat brain by autoradiography

1 reference

12 December 2020

Antitumor cells found in tumor-bearing mice given ubenimex

1 reference

12 December 2020

Analgesic responses elicited by endogenous enkephalins (protected by mixed peptidase inhibitors) in a variety of morphine-sensitive noxious tests.

1 reference

12 December 2020

Chemotherapeutic potential of curcumin for colorectal cancer

1 reference

12 December 2020

The effect of ubenimex on N-methyl-N'-nitro-N-nitrosoguanidine-induced stomach tumor in rats

1 reference

12 December 2020

Immunopotentiation with Ubenimex for prevention of leukemia relapse after allogeneic BMT. The Study Group of Ubenimex for BMT

1 reference

12 December 2020

Inhibition of the enkephalin-metabolizing enzymes by the first systemically active mixed inhibitor prodrug RB 101 induces potent analgesic responses in mice and rats

1 reference

12 December 2020

Monocyte activation by an oral immunomodulator (bestatin) in lymphoma patients following autologous bone marrow transplantation

1 reference

12 December 2020

The ectopeptidases CD10, CD13, CD26, and CD143 are upregulated in gastric cancer

1 reference

12 December 2020

The mode of immunopotentiating action of bestatin: enhanced resistance to Listeria monocytogenes infection

1 reference

12 December 2020

Possible contribution of aminopeptidase N (APN/CD13) to invasive potential enhanced by interleukin-6 and soluble interleukin-6 receptor in human osteosarcoma cell lines

1 reference

12 December 2020

Pain-suppressive effects on various nociceptive stimuli (thermal, chemical, electrical and inflammatory) of the first orally active enkephalin-metabolizing enzyme inhibitor RB 120.

1 reference

12 December 2020

Design, synthesis, and biological evaluation of angiogenesis inhibitors: aromatic enone and dienone analogues of curcumin

1 reference

12 December 2020

Optimization and mechanistic studies of psammaplin A type antibacterial agents active against methicillin-resistant Staphylococcus aureus (MRSA).

1 reference

12 December 2020

Inhibition of the HIV-1 and HIV-2 proteases by curcumin and curcumin boron complexes

1 reference

12 December 2020

Potent inhibition of cerebral aminopeptidases by carbaphethiol, a parenterally active compound

1 reference

12 December 2020

In vitro degradation of opioid peptides by human placental aminopeptidase M.

1 reference

12 December 2020

Nonpeptide small-molecular inhibitors of dipeptidyl peptidase IV: N-phenylphthalimide analogs

1 reference

12 December 2020

Aminopeptidase A, which generates one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, has a key role in central control of arterial blood pressure

1 reference

12 December 2020

Induction of CD13 expression on fresh myeloid leukaemia: correlation of CD13 expression with aminopeptidase-N activity

1 reference

12 December 2020

A betulinic acid glycoside from Schefflera venulosa

1 reference

12 December 2020

Specific inhibitor of puromycin-sensitive aminopeptidase with a homophthalimide skeleton: identification of the target molecule and a structure-activity relationship study

1 reference

12 December 2020

Amastatin, an inhibitor of aminopeptidase A, produced by actinomycetes

1 reference

12 December 2020

Inhibition of tumor cell invasion and matrix degradation by aminopeptidase inhibitors

1 reference

12 December 2020

Review: the role of membrane peptidases in immune functions

1 reference

12 December 2020

Psammaplin A, a natural bromotyrosine derivative from a sponge, possesses the antibacterial activity against methicillin-resistant Staphylococcus aureus and the DNA gyrase-inhibitory activity.

1 reference

12 December 2020

Inhibition of alanyl aminopeptidase induces MAP-kinase p42/ERK2 in the human T cell line KARPAS-299.

1 reference

12 December 2020

Potent and selective inhibition of zinc aminopeptidase A (EC 3.4.11.7, APA) by glutamyl aminophosphinic peptides: importance of glutamyl aminophosphinic residue in the P1 position

1 reference

12 December 2020

Inhibition of lymph node metastasis of P388 leukemia by bestatin in mice

1 reference

12 December 2020

Effects of bestatin on intrauterine growth of rat fetuses

1 reference

12 December 2020

Production of actinonin, an inhibitor of aminopeptidase M, by actinomycetes

1 reference

12 December 2020

Leucine aminopeptidase: bestatin inhibition and a model for enzyme-catalyzed peptide hydrolysis

1 reference

12 December 2020

Immunotherapy with bestatin for acute non-lymphocytic leukemia (ANLL) in adults

1 reference

12 December 2020

Inhibition of alanyl-aminopeptidase suppresses the activation-dependent induction of glycogen synthase kinase-3beta (GSK-3beta) in human T cells

1 reference

12 December 2020

Kidney ectopeptidases. Structure, functions and clinical significance

1 reference

12 December 2020

Dual inhibitors of enkephalin-degrading enzymes (neutral endopeptidase 24.11 and aminopeptidase N) as potential new medications in the management of pain and opioid addiction

1 reference

12 December 2020

Urinary excretion of glycine.prolile dipeptidile aminopeptidase, N-acetyl-beta-D-glucosaminidase, alanine aminopeptidase and low molecular protein in patients with renal cell carcinoma

1 reference

12 December 2020

Hematopoietic differentiation antigens that are membrane-associated enzymes: cutting is the key!

1 reference

12 December 2020

Leukotriene A4 hydrolase. Inhibition by bestatin and intrinsic aminopeptidase activity establish its functional resemblance to metallohydrolase enzymes

1 reference

12 December 2020

Investigation of the active site of aminopeptidase A using a series of new thiol-containing inhibitors

1 reference

12 December 2020

Anticancer potential of curcumin: preclinical and clinical studies.

1 reference

12 December 2020

Determinants essential for the transmissible gastroenteritis virus-receptor interaction reside within a domain of aminopeptidase-N that is distinct from the enzymatic site.

1 reference

12 December 2020

Development of selective tight-binding inhibitors of leukotriene A4 hydrolase

1 reference

12 December 2020

Analysis of amide bond formation with an alpha-hydroxy-beta-amino acid derivative, 3-amino-2-hydroxy-4-phenylbutanoic acid, as an acyl component: byproduction of homobislactone

1 reference

12 December 2020

Effect of bestatin on syngeneic tumors in mice

1 reference

12 December 2020

A new human peptide deformylase inhibitable by actinonin.

1 reference

12 December 2020

Antitumor effect of bestatin combined with bleomycin against hepatoma AH 66 subcutaneously transplanted in rats

1 reference

12 December 2020

Renin inhibitors. Substitution of the leucyl residues of Leu-Leu-Val-Phe-OCH3 with 3-amino-2-hydroxy-5-methylhexanoic acid

1 reference

12 December 2020

Role of aminopeptidase activity in the regulation of the pressor activity of circulating angiotensins

1 reference

12 December 2020

CD13/N-aminopeptidase is involved in the development of dendritic cells and macrophages from cord blood CD34(+) cells

1 reference

12 December 2020

Depressant effect on a C-fibre reflex in the rat, of RB101, a dual inhibitor of enkephalin-degrading enzymes.

1 reference

12 December 2020

Families of zinc metalloproteases.

1 reference

12 December 2020

A new one-Pot method for the synthesis of alpha-siloxyamides from aldehydes or ketones and its application to the synthesis of (-)-bestatin

1 reference

12 December 2020

ISOLATION OF AN AMINOPEPTIDASE FROM KIDNEY PARTICLES

1 reference

12 December 2020

Antisense-mediated inhibition of aminopeptidase N (CD13) markedly decreases growth rates of hematopoietic tumour cells

1 reference

12 December 2020

Psammaplin A, a natural phenolic compound, has inhibitory effect on human topoisomerase II and is cytotoxic to cancer cells

1 reference

12 December 2020

Probestin, a new inhibitor of aminopeptidase M, produced by Streptomyces azureus MH663-2F6. I. Taxonomy, production, isolation, physico-chemical properties and biological activities.

1 reference

12 December 2020

Action of ubenimex on aminopeptidase activities in spleen cells and peritoneal macrophages from mice

1 reference

12 December 2020

Immunophenotype of myeloid cells in myelodysplastic syndromes and its clinical implications

1 reference

12 December 2020

Bestatin, an inhibitor of aminopeptidase B, suppresses the proliferation and differentiation of human B-cells in vitro

1 reference

12 December 2020

Current lead natural products for the chemotherapy of human immunodeficiency virus (HIV) infection

1 reference

12 December 2020

Bromotyrosine-derived natural and synthetic products as inhibitors of mycothiol-S-conjugate amidase

1 reference

12 December 2020

Binding properties of a highly potent and selective iodinated aminopeptidase N inhibitor appropriate for radioautography

1 reference

12 December 2020

Synthesis of p-hydroxyubenimex

1 reference

12 December 2020

Quaternary benzo[c]phenanthridine alkaloids as inhibitors of aminopeptidase N and dipeptidyl peptidase IV.

1 reference

12 December 2020

Metabolism of vasoactive peptides by plasma and purified renal aminopeptidase M.

1 reference

12 December 2020

Inhibitors of neprilysin: design, pharmacological and clinical applications.

1 reference

12 December 2020

Inhibition of aminopeptidases N, A and W

1 reference

12 December 2020

Enhancing effect of ubenimex (bestatin) on proliferation and differentiation of hematopoietic progenitor cells, and the suppressive effect on proliferation of leukemic cell lines via peptidase regulation

1 reference

12 December 2020

Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics

1 reference

12 December 2020

Use of aminopeptidase M as a hypotensive agent in spontaneously hypertensive rats

1 reference

12 December 2020

Separate promoters control transcription of the human aminopeptidase N gene in myeloid and intestinal epithelial cells.

1 reference

12 December 2020

Differential processing of substance P and neurokinin A by plasma dipeptidyl(amino)peptidase IV, aminopeptidase M and angiotensin converting enzyme.

1 reference

12 December 2020

The effect of bestatin on patients with acute and chronic leukemia and malignant lymphoma

1 reference

12 December 2020

Studies concerning the antibiotic actinonin. Part I. The constitution of actinonin. A natural hydroxamic acid with antibiotic activity

1 reference

12 December 2020

Induction of apoptosis by ubenimex (Bestatin) in human non-small-cell lung cancer cell lines

1 reference

12 December 2020

Complete amino acid sequence of human intestinal aminopeptidase N as deduced from cloned cDNA.

1 reference

12 December 2020

CD13-positive anaplastic large cell lymphoma of T-cell origin--a diagnostic and histogenetic problem

1 reference

12 December 2020

Expression of aminopeptidase N (APN) on peripheral blood mononuclear cells' surface as a marker of these cells' transendothelial migration properties in the course of multiple sclerosis

1 reference

12 December 2020

Enkephalin metabolism by microglial aminopeptidase N (CD13)

1 reference

12 December 2020

Identification of point mutations in the aminopeptidase N gene by SSCP analysis and sequencing

1 reference

12 December 2020

Compounds fromEpilobium angustifoliumInhibit the Specific Metallopeptidases ACE, NEP and APN

1 reference

12 December 2020

"Mixed inhibitor-prodrug" as a new approach toward systemically active inhibitors of enkephalin-degrading enzymes

1 reference

12 December 2020

Characterization of aminopeptidases responsible for inactivating endogenous (Met5)enkephalin in brain slices using peptidase inhibitors and anti-aminopeptidase M antibodies

1 reference

12 December 2020

Dipeptidyl(amino)peptidase IV and aminopeptidase M metabolize circulating substance P in vivo

1 reference

12 December 2020

Partial review of immunotherapeutic pharmacology in stem cell transplantation

1 reference

12 December 2020

Differential regulation of aminopeptidase N (CD13) by transendothelial migration and cytokines on human eosinophils

1 reference

12 December 2020

Bisprasin, a novel Ca(2+) releaser with caffeine-like properties from a marine sponge, Dysidea spp., acts on Ca(2+)-induced Ca(2+) release channels of skeletal muscle sarcoplasmic reticulum.

1 reference

12 December 2020

The binding of L-valyl-L-tryptophan to crystalline thermolysin illustrates the mode of interaction of a product of peptide hydrolysis

1 reference

12 December 2020

Growth inhibitory effect of bestatin on choriocarcinoma cell finesin vitro

1 reference

12 December 2020

alpha-Aminomethylketones as inhibitors of a membrane-bound alanine aminopeptidase

1 reference

12 December 2020

Immunophenotype of lymphocytes in pericardial fluid from patients with different forms of heart disease

1 reference

12 December 2020

Acylnitrene Route to Vicinal Amino Alcohols. Application to the Synthesis of (-)-Bestatin and Analogues

1 reference

12 December 2020

Regio- and stereo-specific synthesis of threo-3-amino-2-hydroxy-acids, novel amino-acids contained in aminopeptidase inhibitors of microbial origin

1 reference

12 December 2020

[Study of the prophylactic effect of ubenimex on experimental pyelonephritis induced by Pseudomonas in neutropenic mice]

1 reference

12 December 2020

Soluble aminopeptidase N/CD13 in malignant and nonmalignant effusions and intratumoral fluid

1 reference

12 December 2020

Role of aminopeptidase N (CD13) in tumor-cell invasion and extracellular matrix degradation

1 reference

12 December 2020

Investigation of in vivo activated T cells in multiple sclerosis and inflammatory central nervous system diseases

1 reference

12 December 2020

The significance of aminopeptidases and haematopoietic cell differentiation

1 reference

12 December 2020

Nociceptin/orphanin FQ metabolism: role of aminopeptidase and endopeptidase 24.15.

1 reference

12 December 2020

Synthesis of betulinic acid derivatives with activity against human melanoma

1 reference

12 December 2020

Induction of apoptosis by bestatin (ubenimex) in human leukemic cell lines

1 reference

12 December 2020

Biological significance of aminopeptidase N/CD13 in thyroid carcinomas.

1 reference

12 December 2020

A review of natural and modified betulinic, ursolic and echinocystic acid derivatives as potential antitumor and anti-HIV agents.

1 reference

12 December 2020

Effect of ubenimex on the proliferation and differentiation of U937 human histiocytic lymphoma cells.

1 reference

12 December 2020

Bestatin in resected lung cancer. A randomized clinical trial

1 reference

12 December 2020

Leukotriene A4 hydrolase: a critical role of glutamic acid-296 for the binding of bestatin

1 reference

12 December 2020

Characterization of particulate and soluble variants of the brush-border enzymes alanine aminopeptidase, alkaline phosphatase and gamma-glutamyltransferase in human urine

1 reference

12 December 2020

Randomized Double-Blind Placebo-Controlled Trial of Bestatin in Patients With Resected Stage I Squamous-Cell Lung Carcinoma

1 reference

12 December 2020

Studies concerning the antibiotic actinonin. Part II. Total synthesis of actinonin and some structural analogues by the isomaleimide method

1 reference

12 December 2020

Studies concerning the antibiotic actinon. Part V. Synthesis of structural analogues of actinonin by the anhydride-ester method

1 reference

12 December 2020

Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors

1 reference

12 December 2020

Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes

1 reference

12 December 2020

Bestatin as an experimental tool in mammals

1 reference

12 December 2020

Further characterization of aminopeptidase-N as a receptor for coronaviruses.

1 reference

12 December 2020

[Identification of metabolic pathways of brain angiotensin II and angiotensin III: predominant role of angiotensin III in the control of vasopressin secretion]

1 reference

12 December 2020

Curcumin analogs with altered potencies against HIV-1 integrase as probes for biochemical mechanisms of drug action

1 reference

12 December 2020

[Changes in aminopeptidase N located on neutrophils derived from patients with chronic pain]

1 reference

12 December 2020

Psammaplins from the Sponge Pseudoceratina purpurea: Inhibition of Both Histone Deacetylase and DNA Methyltransferase

1 reference

12 December 2020

Characterization of angiotensin IV-degrading enzymes and receptors on rat mesangial cells

1 reference

12 December 2020

Leuhistin, a new inhibitor of aminopeptidase M, produced by Bacillus laterosporus BMI156-14F1. I. Taxonomy, production, isolation, physico-chemical properties and biological activities.

1 reference

12 December 2020

Synergistic action of DPIV and APN in the regulation of T cell function.

1 reference

12 December 2020

Synthesis and biological evaluation of novel flavone-8-acetic acid derivatives as reversible inhibitors of aminopeptidase N/CD13.

1 reference

12 December 2020

Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis

1 reference

12 December 2020

Lapstatin, a new aminopeptidase inhibitor produced by Streptomyces rimosus, inhibits autogenous aminopeptidases

1 reference

12 December 2020

Actinonin: an Antibiotic Substance produced by an Actinomycete

1 reference

12 December 2020

Aminopeptidase inhibitors inhibit proliferation and induce apoptosis of K562 and STI571-resistant K562 cell lines through the MAPK and GSK-3beta pathways

1 reference

12 December 2020

Biosynthetic study of leuhistin, a new inhibitor of aminopeptidase M.

1 reference

12 December 2020

Demonstration of CD13/aminopeptidase N on synovial fluid T cells from patients with different forms of joint effusions

1 reference

12 December 2020

Molecular pharmacology of endothelin converting enzymes

1 reference

12 December 2020

Clinical significance of aminopeptidase N/CD13 expression in human pancreatic carcinoma

1 reference

12 December 2020

CD13/aminopeptidase N, a novel chemoattractant for T lymphocytes in pulmonary sarcoidosis

1 reference

12 December 2020

Role of alanyl aminopeptidase in growth and function of human T cells (review).

1 reference

12 December 2020

Enkephalin degradating enzymes in pheochromocytoma patients.

1 reference

12 December 2020

Bestatin inhibits covalent coupling of [3H]LTA4 to human leukocyte LTA4hydrolase

1 reference

12 December 2020

Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1.

1 reference

12 December 2020

Design of novel inhibitors of aminopeptidases. Synthesis of peptide-derived diamino thiols and sulfur replacement analogues of bestatin

1 reference

12 December 2020

Bestatin treatment of myelodysplastic syndromes and chronic myelogenous leukemia

1 reference

12 December 2020

The most potent organophosphorus inhibitors of leucine aminopeptidase. Structure-based design, chemistry, and activity

1 reference

12 December 2020

3-Amino-2-hydroxy-propionaldehyde and 3-amino-1-hydroxy-propan-2-one derivatives: new classes of aminopeptidase inhibitors

1 reference

12 December 2020

Anti-tumor angiogenesis effect of aminopeptidase inhibitor bestatin against B16-BL6 melanoma cells orthotopically implanted into syngeneic mice

1 reference

12 December 2020

Inhibition of arginine aminopeptidase by bestatin and arphamenine analogues. Evidence for a new mode of binding to aminopeptidases

1 reference

12 December 2020

Extracellular cysteines define ectopeptidase (APN, CD13) expression and function

1 reference

12 December 2020

Expression of CD13/aminopeptidase N and CD10/neutral endopeptidase on cultured human keratinocytes.

1 reference

12 December 2020

Curcumin exhibits antimetastatic properties by modulating integrin receptors, collagenase activity, and expression of Nm23 and E-cadherin.

1 reference

12 December 2020

Inhibition of aminopeptidase B and leucine aminopeptidase by bestatin and its stereoisomer

1 reference

12 December 2020

Aminopeptidase N is involved in cell motility and angiogenesis: its clinical significance in human colon cancer

1 reference

12 December 2020

Inhibition of tumor invasion and extracellular matrix degradation by ubenimex (bestatin)

1 reference

12 December 2020

Expression of myeloid antigens by blast cells in acute lymphoblastic leukemia of adults. The Southwest Oncology Group experience.

1 reference

12 December 2020

Inhibition of aminopeptidases by amastatin and bestatin derivatives. Effect of inhibitor structure on slow-binding processes

1 reference

12 December 2020

3-Amino-2-tetralone derivatives: novel potent and selective inhibitors of aminopeptidase-M (EC 3.4.11.2)

1 reference

12 December 2020

CD13/APN is activated by angiogenic signals and is essential for capillary tube formation

1 reference

12 December 2020

Aminopeptidase inhibitor Bestatin induces HL-60 cell apoptosis through activating caspase 3

1 reference

12 December 2020

Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells

1 reference

12 December 2020

Aminopeptidase N/CD13 is directly linked to signal transduction pathways in monocytes

1 reference

12 December 2020

Phosphinic derivatives as new dual enkephalin-degrading enzyme inhibitors: synthesis, biological properties, and antinociceptive activities

1 reference

12 December 2020

Cytotoxicity of psammaplin A from a two-sponge association may correlate with the inhibition of DNA replication

1 reference

12 December 2020

Novel small molecule nonpeptide aminopeptidase n inhibitors with a cyclic imide skeleton.

1 reference

12 December 2020

alpha-aminoaldehydes: transition state analogue inhibitors of leucine aminopeptidase

1 reference

12 December 2020

Probestin, a new inhibitor of aminopeptidase M, produced by Streptomyces azureus MH663-2F6. II. Structure determination of probestin

1 reference

12 December 2020

The human aminopeptidase N gene: isolation, chromosome localization, and DNA polymorphism analysis

1 reference

12 December 2020

Transmembrane proteases as disease markers and targets for therapy

1 reference

12 December 2020

Enhancement of antitumor effect of cytotoxic agents by bestatin

1 reference

12 December 2020

Augmentation of death ligand-induced apoptosis by aminopeptidase inhibitors in human solid tumor cell lines

1 reference

12 December 2020

Regulation of angiotensin II receptor subtypes during atrial fibrillation in humans

1 reference

12 December 2020

Structure and function of aminopeptidase N.

1 reference

12 December 2020

Betulinic acid: a promising anticancer candidate

1 reference

12 December 2020

Endostatin binds to the catalytic domain of matrix metalloproteinase-2.

1 reference

12 December 2020

Effect of flavone acetic acid on endothelial cell proliferation: evidence for antiangiogenic properties

1 reference

12 December 2020

Leuhistin, a new inhibitor of aminopeptidase M, produced by Bacillus laterosporus BMI156-14F1. II. Structure determination of leuhistin

1 reference

12 December 2020

Bestatin analogue from Streptomyces neyagawaensis SL-387

1 reference

12 December 2020

Inhibition of human leukocyte function, alanyl aminopeptidase (APN, CD13) and dipeptidylpeptidase IV (DP IV, CD26) enzymatic activities by aqueous extracts of Cistus incanus L. ssp. incanus

1 reference

12 December 2020

Effects of aminopeptidase inhibitors actinonin and amastatin on chemotactic and phagocytic responses of human neutrophils

1 reference

12 December 2020

Cell cycle retardation in monocytoid cells induced by aminopeptidase N (CD13).

1 reference

12 December 2020

Potent and systemically active aminopeptidase N inhibitors designed from active-site investigation.

1 reference

12 December 2020

Psammaplin A, a chitinase inhibitor isolated from the Fijian marine sponge Aplysinella rhax

1 reference

12 December 2020

.alpha.-Keto amide inhibitors of aminopeptidases

1 reference

12 December 2020

Curcuminoids inhibit the angiogenic response stimulated by fibroblast growth factor-2, including expression of matrix metalloproteinase gelatinase B

1 reference

12 December 2020

Lupane triterpenes and derivatives with antiviral activity

1 reference

12 December 2020

Methionine enkephalin is hydrolyzed by aminopeptidase N on CD4+ and CD8+ spleen T cells

1 reference

12 December 2020

Puromycin-sensitive alanyl aminopeptidase from human liver cytosol: purification and characterization

1 reference

12 December 2020

Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase N

1 reference

12 December 2020

Studies concerning the antibiotic actinonin. Part IV. Synthesis of structural analogues of actinonin by the mixed anhydride method

1 reference

12 December 2020

Effect of microsomal leucine aminopeptidase from human placenta (microsomal P-LAP) on pressor response to infused angiotensin II (A-II) in rat

1 reference

12 December 2020

A mini-review of CD13 antigen in AML: easy induction or enhancement of expression in in vitro culture and necessary consideration for assessment

1 reference

12 December 2020

X-ray structure determination of (2S, 3R)-3-amino-2-hydroxy-4-phenylbutanoic acid, a new amino acid component of bestatin.

1 reference

12 December 2020

MEROPS: the peptidase database

1 reference

12 December 2020

Antitumor activity of actinonin in vitro and in vivo

1 reference

12 December 2020

Studies on the mechanisms of action of the immunomodulator Bestatin in various screening test systems.

1 reference

12 December 2020

Synthesis of sulfur-containing analogues of bestatin. Inhibition of aminopeptidases by alpha-thiolbestatin analogues

1 reference

12 December 2020

Enhancement of sensitivity by bestatin of acute promyelocytic leukemia NB4 cells to all-trans retinoic acid

1 reference

12 December 2020

Characterization of Glu350 as a critical residue involved in the N-terminal amine binding site of aminopeptidase N (EC 3.4.11.2): insights into its mechanism of action

1 reference

12 December 2020

Peptidomimetics as receptors agonists or peptidase inhibitors: A structural approach in the field of enkephalins, ANP and CCK

1 reference

12 December 2020

Differential inhibition of aminopeptidase A and aminopeptidase N by new beta-amino thiols

1 reference

12 December 2020

The structure of bestatin

1 reference

12 December 2020

Role of curcumin, a naturally occurring phenolic compound of turmeric in accelerating the repair of excision wound, in mice whole-body exposed to various doses of gamma-radiation

1 reference

12 December 2020

First discrete autoradiographic distribution of aminopeptidase N in various structures of rat brain and spinal cord using the selective iodinated inhibitor [125I]RB 129.

1 reference

12 December 2020

Metabolism of aspartame by human and pig intestinal microvillar peptidases

1 reference

12 December 2020

Potent homophthalimide-type inhibitors of B16F10/L5 mouse melanoma cell invasion

1 reference

12 December 2020

Spinorphin as an endogenous inhibitor of enkephalin-degrading enzymes: roles in pain and inflammation

1 reference

12 December 2020

Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis

1 reference

12 December 2020

New bromotyrosine derivatives from an association of two sponges, Jaspis wondoensis and Poecillastra wondoensis

1 reference

12 December 2020

Inhibitory effect of bestatin on the growth of human lymphocytes

1 reference

12 December 2020

Isolation of Psammaplin A 11‘-Sulfate and Bisaprasin 11‘-Sulfate from the Marine SpongeAplysinellarhax

1 reference

12 December 2020

Identification of metabolic pathways of brain angiotensin II and III using specific aminopeptidase inhibitors: predominant role of angiotensin III in the control of vasopressin release

1 reference

12 December 2020

Specific nonpeptide inhibitors of puromycin-sensitive aminopeptidase with a 2,4(1H,3H)-quinazolinedione skeleton.

1 reference

12 December 2020

CD13--not just a marker in leukemia typing

1 reference

12 December 2020

High-molecular-mass isoform of aminopeptidase N/CD13 in serum from cholestatic patients

1 reference

12 December 2020

Betulinic acid inhibits aminopeptidase N activity

1 reference

12 December 2020

CD13/aminopeptidase N in collagen vascular diseases

1 reference

12 December 2020

Psammaplin A, a marine natural product, inhibits aminopeptidase N and suppresses angiogenesis in vitro.

1 reference

12 December 2020

Role of chemopreventive agents in cancer therapy

1 reference

12 December 2020

Novel potent nonpeptide aminopeptidase N inhibitors with a cyclic imide skeleton

1 reference

12 December 2020

Human melanoma invasion and metastasis enhancement by high expression of aminopeptidase N/CD13

1 reference

12 December 2020

Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling

1 reference

12 December 2020

alpha-Aminoboronic acid derivatives: effective inhibitors of aminopeptidases

1 reference

12 December 2020

CD13 (GP150; aminopeptidase-N): predominant functional activity in blood is localized to plasma and is not cell-surface associated.

1 reference

12 December 2020

Facilitation of enkephalins catabolism inhibitor-induced antinociception by drugs classically used in pain management

1 reference

12 December 2020

Orally potent human renin inhibitors derived from angiotensinogen transition state: design, synthesis, and mode of interaction

1 reference

12 December 2020

Studies concerning the antibiotic actinonin. Part VII. Mass spectra of actinonin and related compounds

1 reference

12 December 2020

Stimulation of cell-mediated immunity by bestatin correlates with reduction of bacterial persistence in experimental chronic Salmonella typhimurium infection

1 reference

12 December 2020

The molecular mechanisms for the antitumorigenic effect of curcumin

1 reference

12 December 2020

Identification of extra- and intracellular alanyl aminopeptidases as new targets to modulate keratinocyte growth and differentiation

1 reference

12 December 2020

Betulinic acid-induced apoptosis in leukemia cells

1 reference

12 December 2020

Analgesic effects of kelatorphan, a new highly potent inhibitor of multiple enkephalin degrading enzymes

1 reference

12 December 2020

Long lasting antinociceptive properties of enkephalin degrading enzyme (NEP and APN) inhibitor prodrugs.

1 reference

12 December 2020

Biochemical and functional characterization of aminopeptidase N expressed by human melanoma cells.

1 reference

12 December 2020

Irreversible inhibition of CD13/aminopeptidase N by the antiangiogenic agent curcumin

1 reference

12 December 2020

Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor

1 reference

12 December 2020

Ectopeptidases in pathophysiology

1 reference

12 December 2020

The chemical synthesis of bestatin

1 reference

12 December 2020

Preclinical approaches to the development of effective immunotherapeutic protocols for the treatment of metastasis

1 reference

12 December 2020

MR-387A and B, new aminopeptidase N inhibitors, produced by Streptomyces neyagawaensis SL-387

1 reference

12 December 2020

Cytotoxic compounds from a two-sponge association.

1 reference

12 December 2020

Enhancement of delayed-type hypersensitivity by bestatin, an inhibitor of aminopeptidase B and leucine aminopeptidase

1 reference

12 December 2020

Hydrazinocurcumin, a novel synthetic curcumin derivative, is a potent inhibitor of endothelial cell proliferation

1 reference

12 December 2020

Synthesis and structure-activity relationships of bestatin analogues, inhibitors of aminopeptidase B

1 reference

12 December 2020

Aminopeptidase inhibitor bestatin stimulates microvascular endothelial cell invasion in a fibrin matrix

1 reference

12 December 2020

Inhibition of aminopeptidase M by alkyl D-cysteinates

1 reference

12 December 2020

Aminophosphinic inhibitors as transition state analogues of enkephalin-degrading enzymes: a class of central analgesics

1 reference

12 December 2020

Combinatorial synthesis through disulfide exchange: discovery of potent psammaplin A type antibacterial agents active against methicillin-resistant Staphylococcus aureus (MRSA).

1 reference

12 December 2020

Inhibitory effect of bestatin on the growth of human leukemic cells

1 reference

12 December 2020

Insights into peptide and protein function: a convergent approach

1 reference

12 December 2020

Immunotherapy with bestatin for acute nonlymphocytic leukemia in adults

1 reference

12 December 2020

Studies concerning the antibiotic actinonin. Part VI. Synthesis of structural analogues of actinonin by dicyclohexylcarbodi-imide coupling reactions

1 reference

12 December 2020

Studies concerning the antibiotic actinonin. Part III. Synthesis structural analogues of actinonin by the anhydride-imide method

1 reference

12 December 2020

Studies on anti-inflammatory agents. V. A new anti-inflammatory constituent of Pyracantha crenulata Roem

1 reference

12 December 2020

New synthetic technology for efficient construction of alpha-hydroxy-beta-amino amides via the Passerini reaction

1 reference

12 December 2020

The chick embryo chorioallantoic membrane as a model for in vivo research on anti-angiogenesis

1 reference

12 December 2020

Modulation of bone marrow cell functions in vitro by Bestatin (ubenimex)

1 reference

12 December 2020

Studies concerning the antibiotic actinonin. Part VIII. Structure-activity relationships in the actinonin series

1 reference

12 December 2020

Inhibition of aminopeptidase N (AP-N) and urokinase-type plasminogen activator (uPA) by zinc suppresses the invasion activity in human urological cancer cells

1 reference

12 December 2020

Ontogenic and adult whole body distribution of aminopeptidase N in rat investigated by in vitro autoradiography.

1 reference

12 December 2020

Substance P and bradykinin are natural inhibitors of CD13/aminopeptidase N.

1 reference

12 December 2020

Sterol and triterpene derivatives from plants inhibit the effects of a tumor promoter, and sitosterol and betulinic acid inhibit tumor formation in mouse skin two-stage carcinogenesis

1 reference

12 December 2020

Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection

1 reference

12 December 2020

N-hydroxy-2-(naphthalene-2-ylsulfanyl)-acetamide, a novel hydroxamic acid-based inhibitor of aminopeptidase N and its anti-angiogenic activity

1 reference

12 December 2020

CD30+ anaplastic large-cell lymphoma with aberrant expression of CD13: case report and review of the literature

1 reference

12 December 2020

Modulation of WNT-5A expression by actinonin: linkage of APN to the WNT-pathway?

1 reference

12 December 2020

Effects of metalloproteinase inhibitors on leukotriene A4 hydrolase in human airway epithelial cells

1 reference

12 December 2020

PC18, a specific aminopeptidase N inhibitor, induces vasopressin release by increasing the half-life of brain angiotensin III.

1 reference

12 December 2020

[Results of follow-up studies on prognosis after immunotherapy with bestatin in acute nonlymphocytic leukemia]

1 reference

12 December 2020

Human aminopeptidase N is a receptor for human coronavirus 229E

1 reference

12 December 2020

Identification and properties of the cell membrane bound leucine aminopeptidase interacting with the potential immunostimulant and chemotherapeutic agent bestatin

1 reference

12 December 2020

An efficient stereoselective synthesis of [3S(1S,9S)]-3-[[[9-(benzoylamino) octahydro-6,10-dioxo-6H-pyridazino-(1,2-a)(1,2)-diazepin-1-yl]-carbonyl ]amino]-4-oxobutanoic acid, an interleukin converting enzyme (ICE) inhibitor

1 reference

12 December 2020