A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36. (Q33991336)

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10 February 2020

title

A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36 (English)

1 reference

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10 February 2020

4

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10 February 2020

Justin D Boyd

2

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author name string

Kim Wilkinson

series ordinal

1

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10 February 2020

Marcie Glicksman

series ordinal

3

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10 February 2020

Joseph El Khoury

series ordinal

5

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10 February 2020

language of work or name

English

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publication date

11 August 2011

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Journal of Biological Chemistry

10 February 2020

published in

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volume

286

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10 February 2020

issue

40

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10 February 2020

page(s)

34914-34922

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describes a project that uses

10 February 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3186388/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

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CD36 overexpression in human brain correlates with beta-amyloid deposition but not with Alzheimer's disease.

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A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid.

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CD36 signals to the actin cytoskeleton and regulates microglial migration via a p130Cas complex.

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Inhibitory effects of ursolic and oleanolic acid on skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate

21 January 2018

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The anti-arthritic effect of ursolic acid on zymosan-induced acute inflammation and adjuvant-induced chronic arthritis models.

21 January 2018

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Regulated expression of CD36 during monocyte-to-macrophage differentiation: potential role of CD36 in foam cell formation

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/21835916

12 December 2020

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Effect of selected triterpenoids on chronic dermal inflammation

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Aggregated ursolic acid, a natural triterpenoid, induces IL-1beta release from murine peritoneal macrophages: role of CD36

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inferred from PubMed ID database lookup

Identifiers

DOI

10.1074/JBC.M111.232116

1 reference

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10 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21835916%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

1 reference