Improved cyclopropanation activity of histidine-ligated cytochrome P450 enables the enantioselective formal synthesis of levomilnacipran (Q33997380)

30 July 2017

title

Improved cyclopropanation activity of histidine-ligated cytochrome P450 enables the enantioselective formal synthesis of levomilnacipran (English)

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30 July 2017

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6

Frances H Arnold

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30 July 2017

Z Jane Wang

1

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30 July 2017

Hans Renata

2

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30 July 2017

Nicole E Peck

3

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30 July 2017

Christopher C Farwell

4

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30 July 2017

Pedro S Coelho

5

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30 July 2017

language of work or name

English

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publication date

6 May 2014

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Angewandte Chemie International Edition

30 July 2017

published in

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volume

53

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30 July 2017

issue

26

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30 July 2017

page(s)

6810-6813

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P450-catalyzed intramolecular sp(3) C-H amination with arylsulfonyl azide substrates.

30 July 2017

cites work

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Rhodium-catalyzed enantioselective cyclopropanation of electron deficient alkenes.

28 July 2018

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Enantioselective intramolecular C-H amination catalyzed by engineered cytochrome P450 enzymes in vitro and in vivo

28 July 2018

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A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo

28 July 2018

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28 July 2018

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Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes

28 July 2018

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P450(BM3) (CYP102A1): connecting the dots.

28 July 2018

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Molecular basis for the inability of an oxygen atom donor ligand to replace the natural sulfur donor heme axial ligand in cytochrome P450 catalysis. Spectroscopic characterization of the Cys436Ser CYP2B4 mutant

28 July 2018

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A compromise required by gene sharing enables survival: Implications for evolution of new enzyme activities

28 July 2018

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Stereoselective cyclopropanation reactions

28 July 2018

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P450 BM3: the very model of a modern flavocytochrome

28 July 2018

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Roles of the proximal heme thiolate ligand in cytochrome p450(cam).

28 July 2018

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28 July 2018

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Crystal structure of horseradish peroxidase C at 2.15 A resolution

28 July 2018

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Structurally engineered cytochromes with unusual ligand-binding properties: expression of Saccharomyces cerevisiae Met-80-->Ala iso-1-cytochrome c

28 July 2018

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Three-dimensional solution structure of the cyanide adduct of a Met80Ala variant of Saccharomyces cerevisiae iso-1-cytochrome c. Identification of ligand-residue interactions in the distal heme cavity

28 July 2018

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Biocatalysis—key to sustainable industrial chemistry

28 July 2018

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Cytochrome P450-Catalyzed Insertion of Carbenoids into N-H Bonds

21 January 2018

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TfNH2 as achiral hydrogen-bond donor additive to enhance the selectivity of a transition metal catalyzed reaction. Highly enantio- and diastereoselective rhodium-catalyzed cyclopropanation of alkenes using alpha-cyano diazoacetamide.

21 January 2018

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Replacement of active-site cysteine-436 by serine converts cytochrome P450 2B4 into an NADPH oxidase with negligible monooxygenase activity

21 January 2018

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Structure of beef liver catalase

21 January 2018

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Redox conformation changes in refined tuna cytochrome c

21 January 2018

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C-H bond activation in heme proteins: the role of thiolate ligation in cytochrome P450.

21 January 2018

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Efficacy and safety of levomilnacipran sustained release 40 mg, 80 mg, or 120 mg in major depressive disorder: a phase 3, randomized, double-blind, placebo-controlled study

21 January 2018

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Enantioselective synthesis of levomilnacipran

21 January 2018

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BuMgNiPr2: a new base for stoichiometric, position-selective deprotonation of cyclopropane carboxamides and other weak CH acids

21 January 2018

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Three-Dimensional Solution Structure of the Cyanide Adduct of a Variant of Saccharomyces cerevisiae Iso-1-cytochrome c Containing the Met80Ala Mutation. Identification of Ligand-Residue Interactions in the Distal Heme Cavity

29 October 2018

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D2-Symmetric Dirhodium Catalyst Derived from a 1,2,2-Triarylcyclopropanecarboxylate Ligand: Design, Synthesis and Application

21 January 2018

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12 December 2020

Recent Advances in Asymmetric Catalytic Metal Carbene Transformations

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12 December 2020

Dirhodium(II) tetrakis[methyl 2-oxaazetidine-4-carboxylate]: a chiral dirhodium(II) carboxamidate of exceptional reactivity and selectivity

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12 December 2020

1-Aryl-2-(aminomethyl)cyclopropanecarboxylic acid derivatives. A new series of potential antidepressants

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12 December 2020

A biocatalytic Henry reaction--the hydroxynitrile lyase from Hevea brasiliensis also catalyzes nitroaldol reactions

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12 December 2020

Dirhodium Tetraprolinate-Catalyzed Asymmetric Cyclopropanations with High Turnover Numbers

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12 December 2020

The bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities

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12 December 2020

Bis(oxazolines) as chiral ligands in metal-catalyzed asymmetric reactions. Catalytic, asymmetric cyclopropanation of olefins

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19 October 2022

https://opencitations.net/index/coci/api/v1/citations/10.1021/JA00002A080

Identifiers

DOI

10.1002/ANIE.201402809

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30 July 2017

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30 July 2017

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