Endocrine regulation of ageing (Q34005604)

30 July 2017

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title

Endocrine regulation of ageing (English)

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30 July 2017

2

C Ronald Kahn

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30 July 2017

Steven J Russell

1

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30 July 2017

1 September 2007

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Nature Reviews Molecular Cell Biology

30 July 2017

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30 July 2017

8

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30 July 2017

9

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30 July 2017

681-691

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https://scigraph.springernature.com/pub.10.1038/nrm2234

30 July 2017

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A C. elegans mutant that lives twice as long as wild type

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The plasticity of aging: insights from long-lived mutants

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Genetic mouse models of extended lifespan

31 March 2020

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Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body

31 March 2020

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Regulation of C. elegans life-span by insulinlike signaling in the nervous system

31 March 2020

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Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan

31 March 2020

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Long-lived Drosophila with overexpressed dFOXO in adult fat body

31 March 2020

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Extended longevity in mice lacking the insulin receptor in adipose tissue

31 March 2020

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Mutation of the mouse klotho gene leads to a syndrome resembling ageing

31 March 2020

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Suppression of aging in mice by the hormone Klotho

31 March 2020

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Steroid control of longevity in Drosophila melanogaster

31 March 2020

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A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function

31 March 2020

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Intercellular signaling of reproductive development by the C. elegans DAF-9 cytochrome P450.

31 March 2020

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Signals from the reproductive system regulate the lifespan of C. elegans

31 March 2020

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A steroid hormone that extends the lifespan of Caenorhabditis elegans.

31 March 2020

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Healthy Animals with Extreme Longevity

31 March 2020

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C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span

31 March 2020

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The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

31 March 2020

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daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans

31 March 2020

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daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans

31 March 2020

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Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling

31 March 2020

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DAF-16 target genes that control C. elegans life-span and metabolism.

31 March 2020

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Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation

31 March 2020

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Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

31 March 2020

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Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span

31 March 2020

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Dynamics of the action of dFOXO on adult mortality in Drosophila.

31 March 2020

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Dwarf mice and the ageing process.

31 March 2020

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Hormone-treated snell dwarf mice regain fertility but remain long lived and disease resistant

31 March 2020

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The Snell dwarf mutation Pit1(dw) can increase life span in mice

31 March 2020

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Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span

31 March 2020

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Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

31 March 2020

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Inherited Ateliotic Dwarfism in Mice: Characteristics of the mutation, little, on Chromosome 6

31 March 2020

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IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

31 March 2020

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Reduced levels of thyroid hormones, insulin, and glucose, and lower body core temperature in the growth hormone receptor/binding protein knockout mouse.

31 March 2020

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Experimental IGF-I receptor deficiency generates a sexually dimorphic pattern of organ-specific growth deficits in mice, affecting fat tissue in particular.

31 March 2020

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Genetic modulation of hormone levels and life span in hybrids between laboratory and wild-derived mice

31 March 2020

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Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

31 March 2020

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Insulin resistance as a predictor of age-related diseases

31 March 2020

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From mice to men: insights into the insulin resistance syndromes

31 March 2020

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Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance

31 March 2020

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Adipose tissue as an endocrine organ

31 March 2020

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Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial

31 March 2020

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Circulating adiponectin levels increase in rats on caloric restriction: the potential for insulin sensitization

31 March 2020

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Adipose tissue intracrinology: potential importance of local androgen/estrogen metabolism in the regulation of adiposity

31 March 2020

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Expression of the 11beta-hydroxysteroid dehydrogenase 2 gene in the mouse

31 March 2020

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Selective expression of an aP2/Fatty Acid Binding Protein 4-Cre transgene in non-adipogenic tissues during embryonic development.

31 March 2020

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PPARgamma activation induces the expression of the adipocyte fatty acid binding protein gene in human monocytes

31 March 2020

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Insulin up-regulates tumor necrosis factor-alpha production in macrophages through an extracellular-regulated kinase-dependent pathway

31 March 2020

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Insulin inhibits apoptosis of macrophage cell line, THP-1 cells, via phosphatidylinositol-3-kinase-dependent pathway

31 March 2020

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Obesity is associated with macrophage accumulation in adipose tissue

31 March 2020

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Estrogen, insulin, and dietary signals cooperatively regulate longevity signals to enhance resistance to oxidative stress in mice

31 March 2020

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Regulation of oxidative stress by the anti-aging hormone klotho

31 March 2020

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The p66shc adaptor protein controls oxidative stress response and life span in mammals

31 March 2020

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In control of biology: of mice, men and Foxes

31 March 2020

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The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

31 March 2020

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Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

31 March 2020

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Targeting foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action.

31 March 2020

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Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.

31 March 2020

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The forkhead transcription factor Foxo1 regulates adipocyte differentiation

31 March 2020

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Transcriptional feedback control of insulin receptor by dFOXO/FOXO1.

31 March 2020

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Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction

31 March 2020

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Sirtuins in aging and age-related disease.

31 March 2020

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C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span

31 March 2020

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The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis

31 March 2020

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The Sirt1 deacetylase modulates the insulin-like growth factor signaling pathway in mammals

31 March 2020

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Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

31 March 2020

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Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

31 March 2020

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Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice

31 March 2020

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Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells

31 March 2020

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Sirtuin activators mimic caloric restriction and delay ageing in metazoans

31 March 2020

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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

31 March 2020

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Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

31 March 2020

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Resveratrol improves health and survival of mice on a high-calorie diet

31 March 2020

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Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides

31 March 2020

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Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein

31 March 2020

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Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane.

31 March 2020

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Disruption of klotho gene causes an abnormal energy homeostasis in mice

31 March 2020

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Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging

31 March 2020

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Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene

31 March 2020

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Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system

31 March 2020

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Regulation of fibroblast growth factor-23 signaling by klotho

31 March 2020

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Fibroblast growth factor (FGF)-23 inhibits renal phosphate reabsorption by activation of the mitogen-activated protein kinase pathway

31 March 2020

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Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes

31 March 2020

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Comprehensive expression atlas of fibroblast growth factors and their receptors generated by a novel robotic in situ hybridization platform.

31 March 2020

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The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel

31 March 2020

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Association of human aging with a functional variant of klotho

31 March 2020

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Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity

31 March 2020

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Regulation of life-span by germ-line stem cells in Caenorhabditis elegans

31 March 2020

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A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span

31 March 2020

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Hormonal signals produced by DAF-9/cytochrome P450 regulate C. elegans dauer diapause in response to environmental cues

31 March 2020

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Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase.

31 March 2020

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DAF-12-dependent rescue of dauer formation in Caenorhabditis elegans by (25S)-cholestenoic acid

31 March 2020

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Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans.

31 March 2020

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A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling

31 March 2020

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The nuclear hormone receptor DAF-12 has opposing effects on Caenorhabditis elegans lifespan and regulates genes repressed in multiple long-lived worms

31 March 2020

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Mutations in insulin signaling pathway alter juvenile hormone synthesis in Drosophila melanogaster.

31 March 2020

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Hormonal pleiotropy and the juvenile hormone regulation of Drosophila development and life history

31 March 2020

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Impaired ovarian ecdysone synthesis of Drosophila melanogaster insulin receptor mutants

31 March 2020

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Ultraspiracle: an invertebrate nuclear receptor for juvenile hormones

31 March 2020

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Functional ecdysone receptor is the product of EcR and Ultraspiracle genes.

31 March 2020

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Insulin signaling is necessary for vitellogenesis in Drosophila melanogaster independent of the roles of juvenile hormone and ecdysteroids: female sterility of the chico1 insulin signaling mutation is autonomous to the ovary

31 March 2020

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An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

31 March 2020

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Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes

31 March 2020

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Steroid hormones and neurosteroids in normal and pathological aging of the nervous system.

31 March 2020

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Respiratory chain dysfunction in skeletal muscle does not cause insulin resistance

31 March 2020

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Age of ovary determines remaining life expectancy in old ovariectomized mice

31 March 2020

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Ligand-dependent interaction of estrogen receptor-alpha with members of the forkhead transcription factor family

31 March 2020

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Estrogen plus progestin and the risk of coronary heart disease

31 March 2020

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Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family

31 March 2020

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The demography of slow aging in male and female Drosophila mutant for the insulin-receptor substrate homologue chico.

31 March 2020

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Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4.

31 March 2020

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A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

31 March 2020

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Interacting genes in nematode dauer larva formation

31 March 2020

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Non-ageing developmental variant of Caenorhabditis elegans

31 March 2020

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Timing requirements for insulin/IGF-1 signaling in C. elegans

31 March 2020

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Brain IRS2 signaling coordinates life span and nutrient homeostasis

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM2234

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PubMed ID

17684529

Dimensions Publication ID

30 July 2017

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1 reference

PubMed ID

17684529