Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes (Q37493137)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15340055%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

title

Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes (English)

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1 January 2020

4

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1 January 2020

author name string

Susumu Kodama

series ordinal

1

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1 January 2020

Chika Koike

series ordinal

2

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1 January 2020

Masahiko Negishi

series ordinal

3

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1 January 2020

language of work or name

English

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publication date

1 September 2004

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Molecular and Cellular Biology

1 January 2020

published in

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1 January 2020

volume

24

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1 January 2020

issue

18

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1 January 2020

page(s)

7931-7940

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Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation

1 January 2020

cites work

1 reference

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Pathophysiological factors affecting CAR gene expression.

23 August 2017

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Induction of drug metabolism: the role of nuclear receptors.

23 August 2017

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Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation

23 August 2017

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Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

23 August 2017

1 reference

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Phenobarbital induction of drug/steroid-metabolizing enzymes and nuclear receptor CAR.

23 August 2017

1 reference

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Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state

23 August 2017

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The forkhead transcription factor Foxo1 regulates adipocyte differentiation

23 August 2017

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AKT-independent protection of prostate cancer cells from apoptosis mediated through complex formation between the androgen receptor and FKHR.

23 August 2017

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FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer

23 August 2017

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Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding

23 August 2017

1 reference

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Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.

23 August 2017

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Regulation of cyp3a gene transcription by the pregnane x receptor

23 August 2017

1 reference

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Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=515037

The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

23 August 2017

1 reference

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Orphan nuclear receptors: the exotics of xenobiotics.

23 August 2017

1 reference

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Ligand-dependent interaction of estrogen receptor-alpha with members of the forkhead transcription factor family

23 August 2017

1 reference

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Forkhead homologue in rhabdomyosarcoma functions as a bifunctional nuclear receptor-interacting protein with both coactivator and corepressor functions

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=515037

Phenobarbital response elements of cytochrome P450 genes and nuclear receptors

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=515037

Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=515037

Regulation of glucose-6-phosphatase gene expression by protein kinase Balpha and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=515037

Regulation of cytochrome P450 (CYP) genes by nuclear receptors.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=515037

Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=515037

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=515037

Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=515037

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=515037

The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene

23 August 2017

1 reference

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Activation by diverse xenochemicals of the 51-base pair phenobarbital-responsive enhancer module in the CYP2B10 gene

23 August 2017

1 reference

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An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

23 August 2017

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Characterization of phenobarbital-inducible mouse Cyp2b10 gene transcription in primary hepatocytes.

23 August 2017

1 reference

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Convergence of peroxisome proliferator-activated receptor gamma and Foxo1 signaling pathways

6 September 2017

1 reference

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Gene- and activation-specific mechanisms for insulin inhibition of basal and glucocorticoid-induced insulin-like growth factor binding protein-1 and phosphoenolpyruvate carboxykinase transcription. Roles of forkhead and insulin response sequences

14 September 2017

1 reference

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The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

28 September 2017

1 reference

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The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module

28 September 2017

1 reference

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The three insulin response sequences in the glucose-6-phosphatase catalytic subunit gene promoter are functionally distinct

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=515037

Estrogen activation of the nuclear orphan receptor CAR (constitutive active receptor) in induction of the mouse Cyp2b10 gene

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=515037

Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=515037

Enzyme inducers improve insulin sensitivity in non-insulin-dependent diabetic subjects.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=515037

Effects of phenobarbital and 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene on differentiated functions in mouse liver

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=515037

Inhibition of gluconeogenesis in isolated rat hepatocytes after chronic treatment with phenobarbital

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=515037

Cytoplasmic Accumulation of the Nuclear Receptor CAR by a Tetratricopeptide Repeat Protein in HepG2 Cells

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=515037

Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=515037

A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=515037

The role of the nuclear receptor CAR as a coordinate regulator of hepatic gene expression in defense against chemical toxicity.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=515037

Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=515037

Diabetes and elimination of antipyrine in man: an analysis of 298 patients classified by type of diabetes, age, sex, duration of disease and liver involvement

2 September 2018

1 reference

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Different expression of hepatic and renal cytochrome P450s between the streptozotocin-induced diabetic mouse and rat.

2 September 2018

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The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.

2 September 2018

1 reference

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Orphan receptor promiscuity in the induction of cytochromes p450 by xenobiotics

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=515037

Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=515037

Cytochrome P450 in livers of diabetic rats: regulation by growth hormone and insulin

2 September 2018

1 reference

12 December 2020

Effects of testosterone and growth hormone treatment on hepatic microsomal P450 expression in the diabetic rat

1 reference

12 December 2020

Identification of an insulin-responsive element in the promoter of the human gene for insulin-like growth factor binding protein-1

1 reference

12 December 2020

Insulin suppresses the induction of CYP2B1 and CYP2B2 gene expression by phenobarbital in adult rat cultured hepatocytes

1 reference

12 December 2020

Insulin-mediated modulation of cytochrome P450 gene induction profiles in primary rat hepatocyte cultures

1 reference

12 December 2020

Phosphorylation/Dephosphorylation steps are crucial for the induction of CYP2B1 and CYP2B2 gene expression by phenobarbital

1 reference

12 December 2020

Hepatocyte nuclear factor-4 is a novel downstream target of insulin via FKHR as a signal-regulated transcriptional inhibitor

1 reference

12 December 2020

Forkhead transcription factor FoxO1 transduces insulin-like growth factor's signal to p27Kip1 in primary skeletal muscle satellite cells

1 reference

12 December 2020

The metabolism of drugs by liver microsomes from alloxan-diabetic rats

1 reference

12 December 2020

DRUG-INDUCED CHANGES IN THE LIVER ENDOPLASMIC RETICULUM: ASSOCIATION WITH DRUG-METABOLIZING ENZYMES

1 reference

12 December 2020

10.1128/MCB.24.18.7931-7940.2004

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15340055%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15340055%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

PubMed publication ID

15340055

1 reference