Target engagement analysis and link to pharmacodynamic endpoint for a novel class of CNS-penetrant and efficacious p38α MAPK inhibitors. (Q34006977)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789302%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

title

Target engagement analysis and link to pharmacodynamic endpoint for a novel class of CNS-penetrant and efficacious p38α MAPK inhibitors (English)

1 reference

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17 March 2020

1 reference

1

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17 March 2020

Daniel Watterson

series ordinal

2

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17 March 2020

3

Linda J Van Eldik

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17 March 2020

publication date

1 May 2014

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Journal of Neuroimmune Pharmacology

17 March 2020

published in

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17 March 2020

volume

9

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17 March 2020

issue

4

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17 March 2020

page(s)

454-460

1 reference

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Creative Commons Attribution 4.0 International

17 March 2020

copyright license

start time

1 May 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Deficiency in p38β MAPK fails to inhibit cytokine production or protect neurons against inflammatory insult in in vitro and in vivo mouse models

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Brain-derived neurotrophic factor-dependent synaptic plasticity is suppressed by interleukin-1β via p38 mitogen-activated protein kinase

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A call for transparent reporting to optimize the predictive value of preclinical research

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The p38 MAP Kinase Family as Regulators of Proinflammatory Cytokine Production in Degenerative Diseases of the CNS.

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Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα

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Accelerating drug discovery for Alzheimer's disease: best practices for preclinical animal studies

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Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)

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Inhibition of Wnt/β-catenin signaling by p38 MAP kinase inhibitors is explained by cross-reactivity with casein kinase Iδ/ɛ.

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Chemokines and chemokine receptors: standing at the crossroads of immunobiology and neurobiology

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Non-specific in vivo inhibition of CK1 by the pyridinyl imidazole p38 inhibitors SB 203580 and SB 202190.

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Microglial physiology: unique stimuli, specialized responses

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Glia proinflammatory cytokine upregulation as a therapeutic target for neurodegenerative diseases: function-based and target-based discovery approaches

5 July 2018

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The blood-brain barrier: bottleneck in brain drug development

5 July 2018

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Comparison of intestinal permeabilities determined in multiple in vitro and in situ models: relationship to absorption in humans

5 July 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24789302

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Chemical genetics define the roles of p38alpha and p38beta in acute and chronic inflammation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24789302

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S11481-014-9543-3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789302%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

17 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789302%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

PubMed publication ID

24789302

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789302%20AND%20SRC:MED&resulttype=core&format=json