Mitogen-activated protein kinases in innate immunity (Q27865268)

PubMed publication ID

23954936

16 November 2016

title

Mitogen-activated protein kinases in innate immunity (English)

1 reference

Nature Reviews Immunology

PubMed publication ID

16 November 2016

Steven C Ley

2

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J Simon C Arthur

series ordinal

1

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language of work or name

English

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publication date

September 2013

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published in

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Signaling in innate immunity and inflammation

volume

13

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issue

9

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page(s)

679-92

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cites work

1 reference

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

31 March 2020

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Regulation of adaptive immunity by the innate immune system

31 March 2020

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Transcriptional control of the inflammatory response

31 March 2020

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Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

31 March 2020

1 reference

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

31 March 2020

1 reference

Targeting of TAK1 in inflammatory disorders and cancer

31 March 2020

1 reference

NK Cell Genesis: A Trick of the Trail

31 March 2020

1 reference

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

31 March 2020

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Essential function for the kinase TAK1 in innate and adaptive immune responses.

31 March 2020

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Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex

31 March 2020

1 reference

Epithelial transforming growth factor β-activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species

31 March 2020

1 reference

Essential roles of K63-linked polyubiquitin-binding proteins TAB2 and TAB3 in B cell activation via MAPKs.

31 March 2020

1 reference

Myeloid TAKI [corrected] acts as a negative regulator of the LPS response and mediates resistance to endotoxemia

31 March 2020

1 reference

The regulation of IL-10 production by immune cells

31 March 2020

1 reference

NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta

31 March 2020

1 reference

ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity.

31 March 2020

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Critical role for apoptosis signal-regulating kinase 1 in the development of inflammatory K/BxN serum-induced arthritis

31 March 2020

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Recruitment of tumor necrosis factor receptor-associated factor family proteins to apoptosis signal-regulating kinase 1 signalosome is essential for oxidative stress-induced cell death

31 March 2020

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Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1

31 March 2020

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GSK-3β-induced ASK1 stabilization is crucial in LPS-induced endotoxin shock.

31 March 2020

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PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation

31 March 2020

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Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3

31 March 2020

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MEKK3 is essential for lipopolysaccharide-induced interleukin-6 and granulocyte-macrophage colony-stimulating factor production in macrophages

31 March 2020

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IκB kinase regulation of the TPL-2/ERK MAPK pathway

31 March 2020

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NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity

31 March 2020

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NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase

31 March 2020

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Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105.

31 March 2020

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Phosphorylation of TPL-2 on serine 400 is essential for lipopolysaccharide activation of extracellular signal-regulated kinase in macrophages

31 March 2020

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IκB kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400

31 March 2020

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Regulation of the immune response by stress-activated protein kinases

31 March 2020

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JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation

31 March 2020

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Alternative activation of macrophages: an immunologic functional perspective

31 March 2020

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Alternative Macrophage Activation and Metabolism

31 March 2020

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TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway

31 March 2020

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TPL-2 negatively regulates interferon-beta production in macrophages and myeloid dendritic cells

31 March 2020

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Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production.

31 March 2020

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Coordinate regulation of TPL-2 and NF-κB signaling in macrophages by NF-κB1 p105.

31 March 2020

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Targeting protein kinases for the development of anti-inflammatory drugs

31 March 2020

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Generation and characterization of p38beta (MAPK11) gene-targeted mice.

31 March 2020

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Macrophage deletion of p38alpha partially impairs lipopolysaccharide-induced cellular activation.

31 March 2020

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Chemical genetics define the roles of p38alpha and p38beta in acute and chronic inflammation

31 March 2020

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The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression

31 March 2020

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Antiinflammatory functions of p38 in mouse models of rheumatoid arthritis: advantages of targeting upstream kinases MKK-3 or MKK-6

31 March 2020

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The -Isoform of p38 MAPK Specifically Regulates Arthritic Bone Loss

31 March 2020

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The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling

31 March 2020

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Feedback control of the protein kinase TAK1 by SAPK2a/p38

31 March 2020

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Eukaryotic elongation factor 2 controls TNF-α translation in LPS-induced hepatitis

31 March 2020

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p38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation

31 March 2020

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MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis

31 March 2020

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Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element

31 March 2020

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The p38/MK2-driven exchange between tristetraprolin and HuR regulates AU-rich element-dependent translation

31 March 2020

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Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements

31 March 2020

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Bone marrow transplantation reproduces the tristetraprolin-deficiency syndrome in recombination activating gene-2 (-/-) mice. Evidence that monocyte/macrophage progenitors may be responsible for TNFalpha overproduction

31 March 2020

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Myeloid-specific tristetraprolin deficiency in mice results in extreme lipopolysaccharide sensitivity in an otherwise minimal phenotype

31 March 2020

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The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK.

31 March 2020

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Stress induced gene expression: a direct role for MAPKAP kinases in transcriptional activation of immediate early genes

31 March 2020

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The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways

31 March 2020

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MSK1 regulates the transcription of IL-1ra in response to TLR activation in macrophages.

31 March 2020

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MSK1 and MSK2 inhibit lipopolysaccharide-induced prostaglandin production via an interleukin-10 feedback loop

31 March 2020

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Posttranslational regulation of tristetraprolin subcellular localization and protein stability by p38 mitogen-activated protein kinase and extracellular signal-regulated kinase pathways.

31 March 2020

1 reference

PGE(2) induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway.

31 March 2020

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The induction of IL-10 by zymosan in dendritic cells depends on CREB activation by the coactivators CREB-binding protein and TORC2 and autocrine PGE2.

31 March 2020

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Dual-specificity MAP kinase phosphatases (MKPs): shaping the outcome of MAP kinase signalling

31 March 2020

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MAPK phosphatases--regulating the immune response

31 March 2020

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Increased inflammation and impaired resistance to Chlamydophila pneumoniae infection in Dusp1(-/-) mice: critical role of IL-6.

31 March 2020

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Increased inflammation and lethality of Dusp1-/- mice in polymicrobial peritonitis models.

31 March 2020

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Increased inflammation, impaired bacterial clearance, and metabolic disruption after gram-negative sepsis in Mkp-1-deficient mice

31 March 2020

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Knockout of Mkp-1 enhances the host inflammatory responses to gram-positive bacteria

31 March 2020

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Control of dual-specificity phosphatase-1 expression in activated macrophages by IL-10.

31 March 2020

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IFN- -mediated inhibition of MAPK phosphatase expression results in prolonged MAPK activity in response to M-CSF and inhibition of proliferation

31 March 2020

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Glutamine suppresses airway neutrophilia by blocking cytosolic phospholipase A(2) via an induction of MAPK phosphatase-1.

31 March 2020

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Glutamine suppresses DNFB-induced contact dermatitis by deactivating p38 mitogen-activated protein kinase via induction of MAPK phosphatase-1.

31 March 2020

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Glutamine protects mice from lethal endotoxic shock via a rapid induction of MAPK phosphatase-1.

31 March 2020

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Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1.

31 March 2020

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Dual specificity phosphatase 1 knockout mice show enhanced susceptibility to anaphylaxis but are sensitive to glucocorticoids.

31 March 2020

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The role of MAP kinase phosphatase-1 in the protective mechanism of dexamethasone against endotoxemia

31 March 2020

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Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling

31 March 2020

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Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1.

31 March 2020

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Mitogen-activated protein kinase phosphatase 2 regulates the inflammatory response in sepsis.

31 March 2020

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MAP kinase phosphatase-2 plays a critical role in response to infection by Leishmania mexicana

31 March 2020

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Macrophage differentiation of myeloid progenitor cells in response to M-CSF is regulated by the dual-specificity phosphatase DUSP5.

31 March 2020

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Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5

31 March 2020

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A non-redundant role for MKP5 in limiting ROS production and preventing LPS-induced vascular injury

31 March 2020

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The role of male chromosomal polymorphism played in spermatogenesis and the outcome of IVF/ICSI-ET treatment

31 March 2020

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Pathogen subversion of cell-intrinsic innate immunity

31 March 2020

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Manipulation of host signalling pathways by anthrax toxins

31 March 2020

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Anthrax toxin induces macrophage death by p38 MAPK inhibition but leads to inflammasome activation via ATP leakage

31 March 2020

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The Leishmania surface protease GP63 cleaves multiple intracellular proteins and actively participates in p38 mitogen-activated protein kinase inactivation

31 March 2020

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An evolutionary analysis of trypanosomatid GP63 proteases.

31 March 2020

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Macrophage signalling upon mycobacterial infection: the MAP kinases lead the way.

31 March 2020

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Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation of DUSP16/MKP-7

31 March 2020

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Yersinia outer proteins: Yops

31 March 2020

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Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation

31 March 2020

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Acetylation of MEK2 and I kappa B kinase (IKK) activation loop residues by YopJ inhibits signaling

31 March 2020

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Serine/threonine acetylation of TGFβ-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling

31 March 2020

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VopA inhibits ATP binding by acetylating the catalytic loop of MAPK kinases

31 March 2020

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Salmonella AvrA Coordinates Suppression of Host Immune and Apoptotic Defenses via JNK Pathway Blockade

31 March 2020

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SpvC is a Salmonella effector with phosphothreonine lyase activity on host mitogen-activated protein kinases

31 March 2020

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The phosphothreonine lyase activity of a bacterial type III effector family

31 March 2020

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Structural insights into the enzymatic mechanism of the pathogenic MAPK phosphothreonine lyase

31 March 2020

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Eliminylation: a post-translational modification catalyzed by phosphothreonine lyases

31 March 2020

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Shigella flexneri type III secreted effector OspF reveals new crosstalks of proinflammatory signaling pathways during bacterial infection

31 March 2020

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The Salmonella kinase SteC targets the MAP kinase MEK to regulate the host actin cytoskeleton

31 March 2020

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Functions of the Salmonella pathogenicity island 2 (SPI-2) type III secretion system effectors

31 March 2020

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The evolution of protein kinase inhibitors from antagonists to agonists of cellular signaling

31 March 2020

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Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders

31 March 2020

1 reference

A 24-week, randomized, double-blind, placebo-controlled, parallel group study of the efficacy of oral SCIO-469, a p38 mitogen-activated protein kinase inhibitor, in patients with active rheumatoid arthritis

31 March 2020

1 reference

Evaluation of the efficacy and safety of pamapimod, a p38 MAP kinase inhibitor, in a double-blind, methotrexate-controlled study of patients with active rheumatoid arthritis

31 March 2020

1 reference

Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies.

31 March 2020

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An oral inhibitor of p38 MAP kinase reduces plasma fibrinogen in patients with chronic obstructive pulmonary disease.

31 March 2020

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Clinical trial of the p38 MAP kinase inhibitor dilmapimod in neuropathic pain following nerve injury.

31 March 2020

1 reference

A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase

31 March 2020

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Essential role for IKKβ in production of type 1 interferons by plasmacytoid dendritic cells.

31 March 2020

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MAPKAP kinase 2-deficient mice are resistant to collagen-induced arthritis

31 March 2020

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A benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor alpha production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation

31 March 2020

1 reference

Central role of the MEK/ERK MAP kinase pathway in a mouse model of rheumatoid arthritis: potential proinflammatory mechanisms

31 March 2020

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Cot/Tpl-2 protein kinase as a target for the treatment of inflammatory disease

31 March 2020

1 reference

Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease

31 March 2020

1 reference

Discovery of Potent and Selective Covalent Inhibitors of JNK

31 March 2020

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ERK5 protein promotes, whereas MEK1 protein differentially regulates, the Toll-like receptor 2 protein-dependent activation of human endothelial cells and monocytes

31 March 2020

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Large-scale discovery of ERK2 substrates identifies ERK-mediated transcriptional regulation by ETV3.

31 March 2020

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Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases

31 March 2020

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MicroRNA-155 is induced during the macrophage inflammatory response

31 March 2020

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Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7

31 March 2020

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MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines

31 March 2020

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Differential requirement of MKK4 and MKK7 in JNK activation by distinct scaffold proteins

31 March 2020

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Mechanisms of MAPK signalling specificity

31 March 2020

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MAP kinase kinase kinases and innate immunity

31 March 2020

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Scaffold proteins of MAP-kinase modules.

31 March 2020

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Involvement of mitogen-activated protein kinase homologues in the regulation of lipopolysaccharide-mediated induction of cyclo-oxygenase-2 but not nitric oxide synthase in RAW 264.7 macrophages.

31 March 2020

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Role of MAP kinase cascades in inducing arginine transporters and nitric oxide synthetase in RAW264 macrophages

31 March 2020

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Induction of inducible nitric oxide synthase-NO* by lipoarabinomannan of Mycobacterium tuberculosis is mediated by MEK1-ERK, MKK7-JNK, and NF-kappaB signaling pathways.

31 March 2020

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Involvement of p38 mitogen-activated protein kinase in lipopolysaccharide-induced iNOS and COX-2 expression in J774 macrophages

31 March 2020

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The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology

31 March 2020

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p47phox, the phagocyte NADPH oxidase/NOX2 organizer: structure, phosphorylation and implication in diseases

31 March 2020

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Cutting edge: MyD88 controls phagocyte NADPH oxidase function and killing of gram-negative bacteria.

31 March 2020

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A specific p47phox -serine phosphorylated by convergent MAPKs mediates neutrophil NADPH oxidase priming at inflammatory sites

31 March 2020

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The tyrosine kinase Syk promotes phagocytosis of Francisella through the activation of Erk

31 March 2020

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Regulation of phagosome maturation by signals from toll-like receptors

31 March 2020

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Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation

31 March 2020

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The emerging role of linear ubiquitination in cell signaling

31 March 2020

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Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses

31 March 2020

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Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation

31 March 2020

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Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling

31 March 2020

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Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents

31 March 2020

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Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway

31 March 2020

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Advances in the development of cancer therapeutics directed against the RAS-mitogen-activated protein kinase pathway

31 March 2020

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Improved survival with MEK inhibition in BRAF-mutated melanoma

31 March 2020

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TAK1 negatively regulates NF-κB and p38 MAP kinase activation in Gr-1+CD11b+ neutrophils

31 March 2020

1 reference

https://pubmed.ncbi.nlm.nih.gov/23954936