Laforin, a dual specificity phosphatase involved in Lafora disease, is present mainly as monomeric form with full phosphatase activity (Q34009801)

30 July 2017

title

Laforin, a dual specificity phosphatase involved in Lafora disease, is present mainly as monomeric form with full phosphatase activity (English)

1 reference

30 July 2017

1 reference

Pascual Sanz

7

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author name string

Vikas V Dukhande

1

1 reference

30 July 2017

Devin M Rogers

2

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30 July 2017

Carlos Romá-Mateo

3

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30 July 2017

Jordi Donderis

4

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30 July 2017

Alberto Marina

5

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30 July 2017

Adam O Taylor

6

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30 July 2017

Matthew S Gentry

8

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30 July 2017

language of work or name

English

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publication date

26 August 2011

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30 July 2017

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30 July 2017

volume

6

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30 July 2017

issue

8

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30 July 2017

page(s)

e24040

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Creative Commons Attribution 4.0 International

30 July 2017

copyright license

start time

26 August 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Laforin, a dual-specificity phosphatase involved in Lafora disease, is phosphorylated at Ser25 by AMP-activated protein kinase.

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Phosphate incorporation during glycogen synthesis and Lafora disease

5 July 2018

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Glycogen hyperphosphorylation underlies lafora body formation

5 July 2018

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Structural basis for the glucan phosphatase activity of Starch Excess4

5 July 2018

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Genetic depletion of the malin E3 ubiquitin ligase in mice leads to lafora bodies and the accumulation of insoluble laforin

5 July 2018

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Lafora disease: insights into neurodegeneration from plant metabolism

5 July 2018

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Conservation of the glucan phosphatase laforin is linked to rates of molecular evolution and the glucan metabolism of the organism

5 July 2018

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Increased endoplasmic reticulum stress and decreased proteasomal function in lafora disease models lacking the phosphatase laforin

5 July 2018

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Dimeric Quaternary Structure of the Prototypical Dual Specificity Phosphatase VH1

5 July 2018

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Abnormal metabolism of glycogen phosphate as a cause for Lafora disease

5 July 2018

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Laforin negatively regulates cell cycle progression through glycogen synthase kinase 3beta-dependent mechanisms.

5 July 2018

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Laforin confers cancer resistance to energy deprivation-induced apoptosis

5 July 2018

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Malin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG)

5 July 2018

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Laforin is a glycogen phosphatase, deficiency of which leads to elevated phosphorylation of glycogen in vivo.

5 July 2018

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Regulation of glycogen synthesis by the laforin-malin complex is modulated by the AMP-activated protein kinase pathway

5 July 2018

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A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease

5 July 2018

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The phosphatase laforin crosses evolutionary boundaries and links carbohydrate metabolism to neuronal disease.

5 July 2018

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Dimerization of protein tyrosine phosphatase sigma governs both ligand binding and isoform specificity

5 July 2018

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Protein tyrosine phosphatases: from genes, to function, to disease

5 July 2018

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Dimerization of Laforin is required for its optimal phosphatase activity, regulation of GSK3beta phosphorylation, and Wnt signaling

5 July 2018

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Epm2a suppresses tumor growth in an immunocompromised host by inhibiting Wnt signaling

5 July 2018

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Laforin, a dual specificity phosphatase that dephosphorylates complex carbohydrates

5 July 2018

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A chloroplast-localized dual-specificity protein phosphatase in Arabidopsis contains a phylogenetically dispersed and ancient carbohydrate-binding domain, which binds the polysaccharide starch

5 July 2018

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Structure and mechanism of ArnA: conformational change implies ordered dehydrogenase mechanism in key enzyme for polymyxin resistance

5 July 2018

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Insights into Lafora disease: malin is an E3 ubiquitin ligase that ubiquitinates and promotes the degradation of laforin

5 July 2018

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5 July 2018

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The power of two: protein dimerization in biology

5 July 2018

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Mutations in NHLRC1 cause progressive myoclonus epilepsy

5 July 2018

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A unique carbohydrate binding domain targets the lafora disease phosphatase to glycogen

5 July 2018

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Lafora's disease: towards a clinical, pathologic, and molecular synthesis

5 July 2018

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Laforin, defective in the progressive myoclonus epilepsy of Lafora type, is a dual-specificity phosphatase associated with polyribosomes

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162602

A revised mechanism for the alkaline phosphatase reaction involving three metal ions

5 July 2018

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Dimerization inhibits the activity of receptor-like protein-tyrosine phosphatase-alpha

5 July 2018

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The structure of the bovine protein tyrosine phosphatase dimer reveals a potential self-regulation mechanism

5 July 2018

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A novel protein tyrosine phosphatase gene is mutated in progressive myoclonus epilepsy of the Lafora type (EPM2)

5 July 2018

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5 July 2018

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Mutations in a gene encoding a novel protein tyrosine phosphatase cause progressive myoclonus epilepsy

5 July 2018

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5 July 2018

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Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase

5 July 2018

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Active site labeling of the Yersinia protein tyrosine phosphatase: the determination of the pKa of the active site cysteine and the function of the conserved histidine 402.

5 July 2018

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Kinetic and mechanistic characterization of a mammalian protein-tyrosine phosphatase, PTP1.

5 July 2018

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Progressive myoclonus epilepsy with Lafora inclusion bodies. I. Clinical, genetic, histopathologic, and biochemical aspects

5 July 2018

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The reversible dissociation of the alkaline phosphatase of Escherichia coli. I. Formation and reactivation of subunits

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162602

Studies in myoclonus epilepsy (Lafora body form). II. Polyglucosans in the systemic deposits of myoclonus epilepsy and in corpora amylacea

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162602

Progressive myoclonus epilepsies: clinical and neurophysiological diagnosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162602

Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy.

5 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0024040

Sap-1/PTPRH activity is regulated by reversible dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0024040

The malin-laforin complex suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0024040

A novel higher plant protein tyrosine phosphatase interacts with SNF1-related protein kinases via a KIS (kinase interaction sequence) domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0024040

Molecular characterization of laforin, a dual-specificity protein phosphatase implicated in Lafora disease.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0024040

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0024040

Escherichia coli expression, refolding and characterization of human laforin

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21887368

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Refined structure of alkaline phosphatase from Escherichia coli at 2.8 A resolution

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21887368

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Specific and reversible inactivation of protein tyrosine phosphatases by hydrogen peroxide: evidence for a sulfenic acid intermediate and implications for redox regulation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21887368

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0024040

1 reference

30 July 2017

0 references

1 reference

30 July 2017

1 reference