Obesity: an epidemic in need of therapeutics (Q34014388)

30 July 2017

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title

Obesity: an epidemic in need of therapeutics (English)

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30 July 2017

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Van der Ploeg LH

1

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30 July 2017

1 August 2000

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Current Opinion in Chemical Biology

30 July 2017

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30 July 2017

4

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30 July 2017

4

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30 July 2017

452-460

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Varying body mass index cutoff points to describe overweight prevalence among U.S. adults: NHANES III (1988 to 1994).

30 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

State-of-the-art-lecture: Obesity-induced hypertension: new concepts from the emerging biology of obesity.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

The prediction of abdominal visceral fat level from body composition and anthropometry: ROC analysis

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Hypertriglyceridemia, insulin resistance, and the metabolic syndrome

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https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Long-term effects of modest weight loss in type II diabetic patients

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Weight loss increases and fat loss decreases all-cause mortality rate: results from two independent cohort studies

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https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Medical hazards of obesity

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https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Environmental contributions to the obesity epidemic

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

The Search for Human Obesity Genes

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

The human obesity gene map: the 1999 update.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Phenotypes in three pedigrees with autosomal dominant obesity caused by haploinsufficiency mutations in the melanocortin-4 receptor gene

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

A frameshift mutation in MC4R associated with dominantly inherited human obesity

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

A frameshift mutation in human MC4R is associated with a dominant form of obesity

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Congenital leptin deficiency is associated with severe early-onset obesity in humans

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Reduced rate of energy expenditure as a risk factor for body-weight gain

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Excess energy intake and low energy expenditure as predictors of obesity

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Metabolic rate and physical development in children at risk of obesity

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Relative weight gain and obesity as a child predict metabolic syndrome as an adult

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Vertical banded gastroplasty for obesity

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Positional cloning of the mouse obese gene and its human homologue

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Weight-reducing effects of the plasma protein encoded by the obese gene

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Serum immunoreactive-leptin concentrations in normal-weight and obese humans

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

The expression of ob gene is not acutely regulated by insulin and fasting in human abdominal subcutaneous adipose tissue

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https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Increased obese mRNA expression in omental fat cells from massively obese humans

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Effects of the obese gene product on body weight regulation in ob/ob mice

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

N-docosahexaenoyl, 3 hydroxytyramine: a dopaminergic compound that penetrates the blood-brain barrier and suppresses appetite

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Viral gene delivery selectively restores feeding and prevents lethality of dopamine-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Brain peptides and obesity: pharmacologic treatment

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Opioid involvement in feeding behaviour and the pathogenesis of certain eating disorders

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Obesity and the hypothalamus: novel peptides for new pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Corticotropin-releasing factor-binding protein concentrations in plasma of patients with hypothalamic-pituitary-adrenal disorders

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Adipogenesis and obesity: rounding out the big picture

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https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

In vivo modulation of Hmgic reduces obesity

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https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Mice lacking melanin-concentrating hormone are hypophagic and lean

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https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Narcolepsy and the hypocretin receptor 2 gene.

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https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Identification and expression cloning of a leptin receptor, OB-R

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https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Hypothalamic CART is a new anorectic peptide regulated by leptin

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

From lesions to leptin: hypothalamic control of food intake and body weight.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Leptin activates hypothalamic CART neurons projecting to the spinal cord.

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https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area.

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https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor

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https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

A receptor subtype involved in neuropeptide-Y-induced food intake

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Novel polymorphisms in the neuropeptide-Y Y5 receptor associated with obesity in Pima Indians

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

A melanocortin agonist reduces neuronal firing rate in rat hypothalamic slices

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Stress, corticotropin-releasing factor, and drug addiction

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

New approaches in the pharmacological treatment of obesity

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https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

A candidate gene for the mouse mutation tubby

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Implication of tubby proteins as transcription factors by structure-based functional analysis

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Loss of bombesin-induced feeding suppression in gastrin-releasing peptide receptor-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Absence of fenfluramine-induced anorexia and reduced c-Fos induction in the hypothalamus and central amygdaloid complex of serotonin 1B receptor knock-out mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Infusion of the serotonin1B (5-HT1B) agonist CP-93,129 into the parabrachial nucleus potently and selectively reduces food intake in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Reduced satiating effect of d -fenfluramine in serotonin 5-HT 2C receptor mutant mice

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Impaired energy homeostasis in C/EBP alpha knockout mice

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Life without white fat: a transgenic mouse

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https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Mechanism of insulin resistance in A-ZIP/F-1 fatless mice

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

PPAR-gamma: adipogenic regulator and thiazolidinedione receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Peroxisome Proliferator-activated Receptor α Activators Improve Insulin Sensitivity and Reduce Adiposity

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

HMGI-C and HMGI(Y) immunoreactivity correlates with cytogenetic abnormalities in lipomas, pulmonary chondroid hamartomas, endometrial polyps, and uterine leiomyomas and is compatible with rearrangement of the HMGI-C and HMGI(Y) genes

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Genetic, hypothalamic and endocrine features of clinical and experimental obesity

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Sibutramine: a serotonin-norepinephrine reuptake-inhibitor for the treatment of obesity

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

One-year treatment of obesity: a randomized, double-blind, placebo-controlled, multicentre study of orlistat, a gastrointestinal lipase inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Orlistat, a lipase inhibitor, for weight maintenance after conventional dieting: a 1-y study

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Role of orlistat in the treatment of obese patients with type 2 diabetes. A 1-year randomized double-blind study

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients. European Multicentre Orlistat Study Group

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Human uncoupling proteins and obesity

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Prodrugs of CL316243: a selective beta3-adrenergic receptor agonist for treating obesity and diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Desensitization of beta3-adrenergic receptor-stimulated adenylyl cyclase activity and lipolysis in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Beta3-adrenergic agonists: potential therapeutics for obesity

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Increase in insulin action and fat oxidation after treatment with CL 316,243, a highly selective beta3-adrenoceptor agonist in humans

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Effects of recombinant leptin therapy in a child with congenital leptin deficiency.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

C-terminal octapeptide of cholecystokinin decreases food intake in man.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Effects of cholecystokinin and caerulein on human eating behavior and pain sensation: a review

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Intravenous enterostatin does not affect single meal food intake in man.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Changes in the microstructure of feeding after administration of enterostatin into the paraventricular nucleus and the amygdala.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

A close look at fenfluramine and dexfenfluramine

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

Efficacy of administration of dexfenfluramine and phentermine, alone and in combination, on ingestive behavior and body weight in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900114-9

7 January 2021

10.1016/S1367-5931(00)00114-9

Identifiers

DOI

1 reference

30 July 2017

1 reference

PubMed ID

10959775