Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function. (Q34016403)

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English	Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function.	scientific article

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17 March 2020

Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function (English)

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17 March 2020

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disseminated intravascular coagulation

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Serpin peptidase inhibitor, clade C (antithrombin), member 1

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GOA release 2020-03-11

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17 March 2020

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17 March 2020

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17 March 2020

Jordan A Shavit

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17 March 2020

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J Keith Joung

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17 March 2020

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Morgan L Maeder

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17 March 2020

Catherine E Richter

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17 March 2020

Philip Tsao

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17 March 2020

Andy H Vo

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17 March 2020

Michael C Huarng

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17 March 2020

Thomas Rode

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17 March 2020

Rohit Mehra

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17 March 2020

Steven T Olson

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29 April 2014

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17 March 2020

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17 March 2020

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17 March 2020

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17 March 2020

142-150

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17 March 2020

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11 June 2022

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Targeted mutation of zebrafish fga models human congenital afibrinogenemia

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Sequence, phylogenetic and variant analyses of antithrombin III.

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Loss of fibrinogen in zebrafish results in symptoms consistent with human hypofibrinogenemia

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5 July 2018

Blood collection for biochemical analysis in adult zebrafish

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5 July 2018

Serpin structure, function and dysfunction

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Ubiquitous transgene expression and Cre-based recombination driven by the ubiquitin promoter in zebrafish

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5 July 2018

Zebrafish von Willebrand factor

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Oligomerized pool engineering (OPEN): an 'open-source' protocol for making customized zinc-finger arrays

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Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis

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Generation and phenotypic analysis of protein S-deficient mice.

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5 July 2018

Rapid mutation of endogenous zebrafish genes using zinc finger nucleases made by Oligomerized Pool ENgineering (OPEN).

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5 July 2018

Inherited antithrombin deficiency: a review

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5 July 2018

Conservation of notochord gene expression across chordates: insights from the Leprecan gene family

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Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis

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An efficient one-step site-directed and site-saturation mutagenesis protocol

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A transposon-mediated gene trap approach identifies developmentally regulated genes in zebrafish

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450 million years of hemostasis.

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The evolution of vertebrate blood coagulation as viewed from a comparison of puffer fish and sea squirt genomes

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The antithrombin P1 residue is important for target proteinase specificity but not for heparin activation of the serpin. Characterization of P1 antithrombin variants with altered proteinase specificity but normal heparin activation

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Antithrombin and its inherited deficiency states.

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29 October 2018

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29 October 2018

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29 October 2018

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Residues Tyr253 and Glu255 in strand 3 of beta-sheet C of antithrombin are key determinants of an exosite made accessible by heparin activation to promote rapid inhibition of factors Xa and IXa.

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29 October 2018

Homozygous antithrombin deficiency type II (99 Leu to Phe mutation) and childhood thromboembolism

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Single amino acid substitutions in the reactive site of antithrombin leading to thrombosis. Congenital substitution of arginine 393 to cysteine in antithrombin Northwick Park and to histidine in antithrombin Glasgow

1 reference

https://pubmed.ncbi.nlm.nih.gov/24782510

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular basis of antithrombin deficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/24782510

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antithrombin Sheffield: amino acid substitution at the reactive site (Arg393 to His) causing thrombosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24782510

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two new antithrombin variants support a role for K114 and R13 in heparin binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/24782510

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antithrombin "Chicago": a functionally abnormal molecule with increased heparin affinity causing familial thrombophilia

1 reference

https://pubmed.ncbi.nlm.nih.gov/24782510

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of blood coagulation in the zebrafish

1 reference

https://pubmed.ncbi.nlm.nih.gov/24782510

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antithrombin Chicago, amino acid substitution of arginine 393 to histidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/24782510

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antithrombin Glasgow, 393 arg to his: A P1reactive site variant with increased heparin affinity but no thrombin inhibitory activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/24782510

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1182/BLOOD-2014-03-561027

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Europe PubMed Central

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17 March 2020

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17 March 2020

PubMed publication ID

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17 March 2020

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