PCNA ubiquitination is important, but not essential for translesion DNA synthesis in mammalian cells. (Q34023036)

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13 February 2020

title

PCNA ubiquitination is important, but not essential for translesion DNA synthesis in mammalian cells (English)

1 reference

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13 February 2020

main subject

protein ubiquitination

1 reference

10

1 reference

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13 February 2020

Peter H L Krijger

2

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13 February 2020

Heinz Jacobs

14

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13 February 2020

author name string

Ayal Hendel

1

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13 February 2020

Noam Diamant

3

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13 February 2020

Zohar Goren

4

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13 February 2020

Petra Langerak

5

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13 February 2020

Jungmin Kim

6

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13 February 2020

Thomas Reissner

7

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13 February 2020

Kyoo-young Lee

8

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13 February 2020

Nicholas E Geacintov

9

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13 February 2020

Kyungjae Myung

11

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13 February 2020

Satoshi Tateishi

12

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13 February 2020

Alan D'Andrea

13

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13 February 2020

Zvi Livneh

15

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13 February 2020

publication date

8 September 2011

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13 February 2020

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13 February 2020

volume

7

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13 February 2020

issue

9

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13 February 2020

page(s)

e1002262

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Creative Commons CC0 License

13 February 2020

copyright license

start time

8 September 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

0 references

cites work

DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibits differential mutagenicity

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HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: existence of an alternative E3 ligase

5 July 2018

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Regulatory Functions of Ubiquitin and SUMO in DNA Repair Pathways

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Separate roles of structured and unstructured regions of Y-family DNA polymerases

5 July 2018

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Role of the ubiquitin-binding domain of Polη in Rad18-independent translesion DNA synthesis in human cell extracts.

5 July 2018

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DNA polymerase eta lacking the ubiquitin-binding domain promotes replicative lesion bypass in humans cells

5 July 2018

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Regulation of translesion synthesis DNA polymerase eta by monoubiquitination

5 July 2018

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Multiple two-polymerase mechanisms in mammalian translesion DNA synthesis.

5 July 2018

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CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis

5 July 2018

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DNA polymerase zeta cooperates with polymerases kappa and iota in translesion DNA synthesis across pyrimidine photodimers in cells from XPV patients.

5 July 2018

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Multiple human single-stranded DNA binding proteins function in genome maintenance: structural, biochemical and functional analysis

5 July 2018

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Separate domains of Rev1 mediate two modes of DNA damage bypass in mammalian cells

5 July 2018

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Ubiquitination and deubiquitination of PCNA in response to stalling of the replication fork

5 July 2018

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Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype.

5 July 2018

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Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals

5 July 2018

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Roles of PCNA-binding and ubiquitin-binding domains in human DNA polymerase eta in translesion DNA synthesis

5 July 2018

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REV1 restrains DNA polymerase zeta to ensure frame fidelity during translesion synthesis of UV photoproducts in vivo

5 July 2018

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Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells

5 July 2018

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PCNA ubiquitination and REV1 define temporally distinct mechanisms for controlling translesion synthesis in the avian cell line DT40.

5 July 2018

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5 July 2018

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DNA damage-induced ubiquitylation of RFC2 subunit of replication factor C complex

5 July 2018

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5 July 2018

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5 July 2018

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What a difference a decade makes: insights into translesion DNA synthesis

5 July 2018

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Mutations in the ubiquitin binding UBZ motif of DNA polymerase eta do not impair its function in translesion synthesis during replication

5 July 2018

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A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification

5 July 2018

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PCNA, the maestro of the replication fork

5 July 2018

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A role for PCNA ubiquitination in immunoglobulin hypermutation

5 July 2018

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Keeping mammalian mutation load in check: regulation of the activity of error-prone DNA polymerases by p53 and p21.

5 July 2018

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Gaps and forks in DNA replication: Rediscovering old models

5 July 2018

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Rad18 regulates DNA polymerase kappa and is required for recovery from S-phase checkpoint-mediated arrest

5 July 2018

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Regulation of monoubiquitinated PCNA by DUB autocleavage

5 July 2018

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Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis

5 July 2018

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Suffering in silence: the tolerance of DNA damage

5 July 2018

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Eukaryotic translesion synthesis DNA polymerases: specificity of structure and function

5 July 2018

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Quantitative analysis of translesion DNA synthesis across a benzo[a]pyrene-guanine adduct in mammalian cells: the role of DNA polymerase kappa

5 July 2018

1 reference

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Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination

5 July 2018

1 reference

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Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage

5 July 2018

1 reference

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Opposing effects of ubiquitin conjugation and SUMO modification of PCNA on replicational bypass of DNA lesions in Saccharomyces cerevisiae

5 July 2018

1 reference

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Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation

5 July 2018

1 reference

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Enhanced genomic instability and defective postreplication repair in RAD18 knockout mouse embryonic stem cells

5 July 2018

1 reference

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RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169526

Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169526

hRAD30 mutations in the variant form of xeroderma pigmentosum

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169526

The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169526

P21Cip1/WAF1 downregulation is required for efficient PCNA ubiquitination after UV irradiation

5 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002262

Ubiquitin-binding motif of human DNA polymerase eta is required for correct localization

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002262

Reduced efficiency and increased mutagenicity of translesion DNA synthesis across a TT cyclobutane pyrimidine dimer, but not a TT 6-4 photoproduct, in human cells lacking DNA polymerase eta.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002262

p53 and p21 regulate error-prone DNA repair to yield a lower mutation load

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21931560

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PGEN.1002262

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21931560%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21931560%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

PubMed publication ID

21931560

1 reference