Biosafety assessment of site-directed transgene integration in human umbilical cord-lining cells (Q34025078)

30 July 2017

title

Biosafety assessment of site-directed transgene integration in human umbilical cord-lining cells (English)

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30 July 2017

author name string

Jaichandran Sivalingam

1

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30 July 2017

Shruti Krishnan

2

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30 July 2017

Wai Har Ng

3

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30 July 2017

Sze Sing Lee

4

1 reference

30 July 2017

Toan Thang Phan

5

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30 July 2017

Oi Lian Kon

6

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30 July 2017

publication date

27 April 2010

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30 July 2017

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30 July 2017

volume

18

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30 July 2017

issue

7

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30 July 2017

page(s)

1346-1356

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PhiC31 integrase induces a DNA damage response and chromosomal rearrangements in human adult fibroblasts

30 July 2017

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5 July 2018

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Mutational derivatives of PhiC31 integrase with increased efficiency and specificity

5 July 2018

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Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

5 July 2018

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5 July 2018

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Characterization and genetic manipulation of human umbilical cord vein mesenchymal stem cells: potential application in cell-based gene therapy

5 July 2018

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Clonal selection in malignant transformation of human fibroblasts transduced with defined cellular oncogenes

5 July 2018

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Umbilical cord blood: a unique source of pluripotent stem cells for regenerative medicine

5 July 2018

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5 July 2018

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Gene therapy for childhood immunological diseases

5 July 2018

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Creation of engineered human embryonic stem cell lines using phiC31 integrase

5 July 2018

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Concise review: human umbilical cord stroma with regard to the source of fetus-derived stem cells

5 July 2018

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Spectral karyotyping detects chromosome damage in bronchial cells of smokers and patients with cancer

5 July 2018

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Stem cells in the umbilical cord

5 July 2018

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5 July 2018

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The phiC31 integrase system for gene therapy

5 July 2018

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Molecular analysis of chromosomal rearrangements in mammalian cells after phiC31-mediated integration

5 July 2018

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Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.

5 July 2018

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Retroviral vector integration deregulates gene expression but has no consequence on the biology and function of transplanted T cells.

5 July 2018

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Integration specificity of phage phiC31 integrase in the human genome

5 July 2018

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Enhancement of plasmid-mediated gene therapy for muscular dystrophy by directed plasmid integration.

5 July 2018

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5 July 2018

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Intrinsic tumour suppression

5 July 2018

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Preclinical animal models for hemophilia gene therapy: predictive value and limitations

5 July 2018

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5 July 2018

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Bioengineering of coagulation factor VIII for improved secretion

5 July 2018

1 reference

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LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

5 July 2018

1 reference

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Transcription start regions in the human genome are favored targets for MLV integration

5 July 2018

1 reference

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5 July 2018

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Directed evolution of a recombinase for improved genomic integration at a native human sequence

5 July 2018

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Gene therapy: promises and problems.

5 July 2018

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A phage integrase directs efficient site-specific integration in human cells

5 July 2018

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Gene therapy for hemophilia A: production of therapeutic levels of human factor VIII in vivo in mice

5 July 2018

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Antidesmosomal monoclonal antibody in the diagnosis of intracranial tumours

5 July 2018

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De novo balanced chromosome rearrangements and extra marker chromosomes identified at prenatal diagnosis: clinical significance and distribution of breakpoints

5 July 2018

1 reference

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In situ hybridization and detection using nonisotopic probes

5 July 2018

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Long-term engraftment of single genetically modified human epidermal holoclones enables safety pre-assessment of cutaneous gene therapy

29 October 2018

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Phi c31 integrase induces chromosomal aberrations in primary human fibroblasts

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911251

A direct comparison of two nonviral gene therapy vectors for somatic integration: in vivo evaluation of the bacteriophage integrase phiC31 and the Sleeping Beauty transposase

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911251

In vivo correction of murine hereditary tyrosinemia type I by phiC31 integrase-mediated gene delivery.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911251

Stable nonviral genetic correction of inherited human skin disease

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911251

Targeted disruption of the mouse factor VIII gene produces a model of haemophilia A

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911251

The cellular origins of the linear IgA disease target antigens: an indirect immunofluorescence study using cultured human keratinocytes and fibroblasts

29 October 2018

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12 December 2020

Fusion genes and rearranged genes as a linear function of chromosome aberrations in cancer

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12 December 2020

Mutagenesis of a potential immunoglobulin-binding protein-binding site enhances secretion of coagulation factor VIII

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12 December 2020

Multipotent Stem Cells from Umbilical Cord: Cord Is Richer than Blood!

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12 December 2020

Common features of umbilical cord epithelial cells and epidermal keratinocytes

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12 December 2020

De novobalanced chromosome rearrangements in prenatal diagnosis

1 reference

12 December 2020

Identifiers

DOI

10.1038/MT.2010.61

1 reference

30 July 2017

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30 July 2017

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