Intrinsic tumour suppression (Q35953133)

11 August 2017

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title

Intrinsic tumour suppression (English)

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11 August 2017

Scott W Lowe

1

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11 August 2017

Enrique Cepero

series ordinal

2

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11 August 2017

Gerard Evan

series ordinal

3

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11 August 2017

language of work or name

English

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publication date

1 November 2004

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11 August 2017

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11 August 2017

432

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11 August 2017

307-315

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11 August 2017

7015

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https://scigraph.springernature.com/pub.10.1038/nature03098

11 August 2017

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cites work

Induction of apoptosis in fibroblasts by c-myc protein

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https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Proliferation, cell cycle and apoptosis in cancer

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https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Control of apoptosis by p53.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Cell death: critical control points

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https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

The Bcl-2 family: roles in cell survival and oncogenesis.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

The pathophysiology of mitochondrial cell death

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https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

The CD95(APO-1/Fas) DISC and beyond

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Upstream regulatory role for XIAP in receptor-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Two CD95 (APO-1/Fas) signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

p53 has a direct apoptogenic role at the mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Regulation of the cell cycle and apoptosis by the oncogenes of adenovirus

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

p53-dependent apoptosis suppresses tumor growth and progression in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Suppression of tumorigenesis by the p53 target PUMA

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Dissecting p53 tumor suppressor functions in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Tumor suppression by Ink4a-Arf: progress and puzzles

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

The INK4a/ARF network in tumour suppression

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

E1A signaling to p53 involves the p19(ARF) tumor suppressor

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

The oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

p19(ARF) is dispensable for oncogenic stress-induced p53-mediated apoptosis and tumor suppression in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Atm is dispensable for p53 apoptosis and tumor suppression triggered by cell cycle dysfunction

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

The DNA damage checkpoint in embryonic cell cycles is dependent on the DNA-to-cytoplasmic ratio

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

p53 leans on its siblings

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

On the shoulders of giants: p63, p73 and the rise of p53.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

p63 and p73 are not required for the development and p53-dependent apoptosis of T cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Chemosensitivity linked to p73 function

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

E1A sensitizes cells to tumor necrosis factor alpha by downregulating c-FLIP S.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

c-Myc augments the apoptotic activity of cytosolic death receptor signaling proteins by engaging the mitochondrial apoptotic pathway

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Direct repression of the Mcl-1 promoter by E2F1.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Bim is a suppressor of Myc-induced mouse B cell leukemia

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Direct coupling of the cell cycle and cell death machinery by E2F.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Identification of positively and negatively acting elements regulating expression of the E2F2 gene in response to cell growth signals

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Myc requires distinct E2F activities to induce S phase and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

ARF differentially modulates apoptosis induced by E2F1 and Myc.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by E2f1 loss.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Dual functions of E2F-1 in a transgenic mouse model of liver carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Hallmarks of senescence in carcinogenesis and cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

The ink4a/arf tumor suppressors cooperate with p21cip1/waf in the processes of mouse epidermal differentiation, senescence, and carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Repression of the human papillomavirus E6 gene initiates p53-dependent, telomerase-independent senescence and apoptosis in HeLa cervical carcinoma cells.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

p53 and E2F-1 cooperate to mediate apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Normal human fibroblasts are resistant to RAS-induced senescence

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

p19Arf suppresses growth, progression, and metastasis of Hras-driven carcinomas through p53-dependent and -independent pathways

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Social controls on cell survival and cell death

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Molecular mechanisms of "detachment-induced apoptosis--Anoikis".

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Homeostatic control of lymphocyte survival: potential origins and implications

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Regulation of Bcl-xL: a little bit of this and a little bit of STAT.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

The new kid on the block(ade) of the IGF-1 receptor

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Induction of ovarian cancer by defined multiple genetic changes in a mouse model system

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Arf tumor suppressor promoter monitors latent oncogenic signals in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

CIAP1 and the serine protease HTRA2 are involved in a novel p53-dependent apoptosis pathway in mammals.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Characterization of XIAP-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Apoptosis: a link between cancer genetics and chemotherapy

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Essential role for oncogenic Ras in tumour maintenance

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Reversible tumorigenesis by MYC in hematopoietic lineages

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Simultaneous modulation of multidrug resistance and antiapoptotic cellular defense by MDR1 and BCL-2 targeted antisense oligonucleotides enhances the anticancer efficacy of doxorubicin.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Novel cancer therapy by reactivation of the p53 apoptosis pathway.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03098

7 January 2021

Identifiers

DOI

10.1038/NATURE03098

1 reference

Dimensions Publication ID

11 August 2017

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1 reference