Lysine-specific demethylase 2B (KDM2B)-let-7-enhancer of zester homolog 2 (EZH2) pathway regulates cell cycle progression and senescence in primary cells. (Q34027680)

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English	Lysine-specific demethylase 2B (KDM2B)-let-7-enhancer of zester homolog 2 (EZH2) pathway regulates cell cycle progression and senescence in primary cells.	scientific article

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7 February 2020

Lysine-specific demethylase 2B (KDM2B)-let-7-enhancer of zester homolog 2 (EZH2) pathway regulates cell cycle progression and senescence in primary cells (English)

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7 February 2020

Gianmarco Contino

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7 February 2020

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7 February 2020

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Alexandros Tzatsos

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7 February 2020

Polina Paskaleva

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7 February 2020

Stephania Lymperi

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7 February 2020

Svetlana Stoykova

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7 February 2020

Zhao Chen

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7 February 2020

Nabeel Bardeesy

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11 July 2011

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7 February 2020

Journal of Biological Chemistry

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7 February 2020

286

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7 February 2020

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7 February 2020

33061-33069

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7 February 2020

KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia

1 reference

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28 July 2018

MiR-26a inhibits cell growth and tumorigenesis of nasopharyngeal carcinoma through repression of EZH2

1 reference

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28 July 2018

Aging and microRNA expression in human skeletal muscle: a microarray and bioinformatics analysis

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MicroRNA let-7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2.

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28 July 2018

CpG islands recruit a histone H3 lysine 36 demethylase

1 reference

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28 July 2018

Mir-214-dependent regulation of the polycomb protein Ezh2 in skeletal muscle and embryonic stem cells

1 reference

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BCOR regulates mesenchymal stem cell function by epigenetic mechanisms

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Raptor binds the SAIN (Shc and IRS-1 NPXY binding) domain of insulin receptor substrate-1 (IRS-1) and regulates the phosphorylation of IRS-1 at Ser-636/639 by mTOR

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Anchorage-independent cell growth signature identifies tumors with metastatic potential

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The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2.

1 reference

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Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus

1 reference

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let-7 Overexpression leads to an increased fraction of cells in G2/M, direct down-regulation of Cdc34, and stabilization of Wee1 kinase in primary fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190920

28 July 2018

Deregulated expression of miR-26a and Ezh2 in rhabdomyosarcoma

1 reference

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28 July 2018

Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190920

28 July 2018

Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190920

28 July 2018

dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190920

28 July 2018

The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15(Ink4b)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190920

28 July 2018

The let-7 family of microRNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190920

28 July 2018

MYC stimulates EZH2 expression by repression of its negative regulator miR-26a

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190920

28 July 2018

Replicative senescence of mesenchymal stem cells: a continuous and organized process

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190920

28 July 2018

Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190920

28 July 2018

let-7 regulates self renewal and tumorigenicity of breast cancer cells

1 reference

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p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190920

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The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

1 reference

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1 reference

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Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets

1 reference

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Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.

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The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation

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28 July 2018

EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190920

28 July 2018

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

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https://api.crossref.org/works/10.1074%2FJBC.M111.257667

21 January 2018

Enhancer of Zeste homolog 2 (EZH2) is overexpressed in recurrent nasopharyngeal carcinoma and is regulated by miR-26a, miR-101, and miR-98.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.257667

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21 January 2018

Facile means for quantifying microRNA expression by real-time PCR

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Human multipotent stromal cells undergo sharp transition from division to development in culture

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Senescence of activated stellate cells limits liver fibrosis

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21 January 2018

Ink4a/Arf regulation by let-7b and Hmga2: a genetic pathway governing stem cell aging.

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21 January 2018

Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly

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21 January 2018

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10.1074/JBC.M111.257667

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7 February 2020

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7 February 2020

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