Tat as a transcriptional activator and a potential therapeutic target for HIV-1. (Q34033142)

30 July 2017

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title

Tat as a transcriptional activator and a potential therapeutic target for HIV-1. (English)

1 reference

30 July 2017

Gatignol A

1

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PubMed ID

10987092

30 July 2017

Jeang KT

series ordinal

2

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30 July 2017

1 January 2000

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30 July 2017

Advances in Pharmacology

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30 July 2017

48

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30 July 2017

209-227

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Structure of HIV-1 TAR RNA in the absence of ligands reveals a novel conformation of the trinucleotide bulge

30 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Finding prospective partners in the library: the two-hybrid system and phage display find a match

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Effects of human chromosome 12 on interactions between Tat and TAR of human immunodeficiency virus type 1.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Activation of integrated provirus requires histone acetyltransferase. p300 and P/CAF are coactivators for HIV-1 Tat

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Oncogenic potential of TAR RNA binding protein TRBP and its regulatory interaction with RNA-dependent protein kinase PKR.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

TAR-independent activation of the HIV-1 LTR: evidence that tat requires specific regions of the promoter

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Detailed mutational analysis of TAR RNA: critical spacing between the bulge and loop recognition domains

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Tat trans-activates the human immunodeficiency virus through a nascent RNA target

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Recruitment of a protein complex containing Tat and cyclin T1 to TAR governs the species specificity of HIV-1 Tat.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Expression of TAR RNA-Binding Protein in Baculovirus and Co-Immunoprecipitation with Insect Cell Protein Kinase.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Three functional classes of transcriptional activation domain

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Infection and replication of Tat- human immunodeficiency viruses: genetic analyses of LTR and tat mutations in primary and long-term human lymphoid cells

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Tat activates human immunodeficiency virus type 1 transcriptional elongation independent of TFIIH kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Cloning of an intrinsic human TFIID subunit that interacts with multiple transcriptional activators

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Requirements for RNA polymerase II carboxyl-terminal domain for activated transcription of human retroviruses human T-cell lymphotropic virus I and HIV-1

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Selection of biologically active peptides by phage display of random peptide libraries

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

The human immunodeficiency virus type 1 Tat antagonist, Ro 5-3335, predominantly inhibits transcription initiation from the viral promoter

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

TAR and Sp1-independent transactivation of HIV long terminal repeat by the Tat protein in the presence of human cytomegalovirus IE1/IE2.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Binding of Hoechst 33258 to the TAR RNA of HIV-1. Recognition of a pyrimidine bulge-dependent structure

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Identification of Limiting Steps for Efficient Trans-activation of HIV-1 Promoter by Tat inSaccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Analysis of a binding difference between the two dsRNA-binding domains in TRBP reveals the modular function of a KR-helix motif

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

The trans-activator gene of the human T cell lymphotropic virus type III is required for replication

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Carbocyclic adenosine analogues as S-adenosylhomocysteine hydrolase inhibitors and antiviral agents: recent advances

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

A small-molecule inhibitor directed against the chemokine receptor CXCR4 prevents its use as an HIV-1 coreceptor

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

An Arg/Lys-rich core peptide mimics TRBP binding to the HIV-1 TAR RNA upper-stem/loop.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

HIV-1 tat trans-activation requires the loop sequence within tar.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Inhibition of Tat-mediated transactivation and HIV replication with Tat mutant and repressor domain fusion proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Diminished production of human immunodeficiency virus type 1 in astrocytes results from inefficient translation of gag, env, and nef mRNAs despite efficient expression of Tat and Rev

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Conformational heterogeneity in two regions of TAT results in structural variations of this protein as a function of HIV-1 isolates

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

A new class of HIV-1 Tat antagonist acting through Tat-TAR inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

TAR loop-dependent human immunodeficiency virus trans activation requires factors encoded on human chromosome 12.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Three transitions in the RNA polymerase II transcription complex during initiation

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Interaction of human immunodeficiency virus type 1 Tat with the transcriptional coactivators p300 and CREB binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Inhibition of HIV replication in acute and chronic infections in vitro by a Tat antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Antiviral activities of methylated nordihydroguaiaretic acids. 1. Synthesis, structure identification, and inhibition of tat-regulated HIV transactivation

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

A discrete element 3' of human immunodeficiency virus 1 (HIV-1) and HIV-2 mRNA initiation sites mediates transcriptional activation by an HIV trans activator

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Tat, Tat-associated kinase, and transcription

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Multifaceted activities of the HIV-1 transactivator of transcription, Tat.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Control of RNA initiation and elongation at the HIV-1 promoter

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Taking a new TAK on tat transactivation

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Direct interaction of human TFIID with the HIV-1 transactivator tat

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Transfer of Tat and release of TAR RNA during the activation of the human immunodeficiency virus type-1 transcription elongation complex

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

The regulation of human immunodeficiency virus type-1 gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Evolution of a disrupted TAR RNA hairpin structure in the HIV-1 virus.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Genetic mapping in human and mouse of the locus encoding TRBP, a protein that binds the TAR region of the human immunodeficiency virus (HIV-1)

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Role of the human and murine cyclin T proteins in regulating HIV-1 tat-activation

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

HIV-1 Tat protein increases transcriptional initiation and stabilizes elongation

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

An autoregulated dual-function antitat gene for human immunodeficiency virus type 1 gene therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Characterization of the solution conformations of unbound and Tat peptide-bound forms of HIV-1 TAR RNA

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

The C-terminal domain of RNA polymerase II couples mRNA processing to transcription

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Keto/enol epoxy steroids as HIV-1 Tat inhibitors: structure-activity relationships and pharmacophore localization

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

A chimeric human immunodeficiency virus type 1 TAR region which mediates high level trans-activation in both rodent and human cells

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Interactions between Tat of HIV-2 and transcription factor Sp1

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Identification of multiple cyclin subunits of human P-TEFb

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

The HIV-1 inducer of short transcripts activates the synthesis of 5,6-dichloro-1-beta-D-benzimidazole-resistant short transcripts in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Tat-associated kinase (P-TEFb): a component of transcription preinitiation and elongation complexes

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Biochemical and functional interactions between HIV-1 Tat protein and TAR RNA.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Molecular Cloning and Characterization of a TAR-Binding Nuclear Factor from T Cells

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

A synthetic mimic of a discontinuous binding site on interleukin-10.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Inhibition of HIV-1 replication in viral mutants with altered TAR RNA stem structures

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Structural requirements for trans activation of human immunodeficiency virus type 1 long terminal repeat-directed gene expression by tat: importance of base pairing, loop sequence, and bulges in the tat-responsive sequence.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Transactivation induced by human T-lymphotropic virus type III (HTLV III) maps to a viral sequence encoding 58 amino acids and lacks tissue specificity

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Structure, sequence, and position of the stem-loop in tar determine transcriptional elongation by tat through the HIV-1 long terminal repeat

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Trans-activation by HIV-1 Tat via a heterologous RNA binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Characterization of the inducer of short transcripts, a human immunodeficiency virus type 1 transcriptional element that activates the synthesis of short RNAs.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Histone acetyltransferases regulate HIV-1 enhancer activity in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Activation of transcription by HIV-1 Tat protein tethered to nascent RNA through another protein

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

The HIV-1 Tat protein activates transcription from an upstream DNA-binding site: implications for Tat function

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Transcriptional activity of the human immunodeficiency virus-1 LTR promoter in fission yeast Schizosaccharomyces pombe

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Chromatin disruption in the promoter of human immunodeficiency virus type 1 during transcriptional activation.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

A second-site mutation that restores replication of a Tat-defective human immunodeficiency virus

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Optimal Tat-mediated activation of the HIV-1 LTR promoter requires a full-length TAR RNA hairpin

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Evidence for functional interaction between the HIV-1 Tat transactivator and the TATA box binding protein in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Promoter activity of Tat at steps subsequent to TATA-binding protein recruitment

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Transcriptional control: Tat cofactors and transcriptional elongation

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Novel mechanism and factor for regulation by HIV-1 Tat

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

Transcription elongation factor P-TEFb is required for HIV-1 tat transactivation in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2800%2948007-5

7 January 2021

10.1016/S1054-3589(00)48007-5

Identifiers

DOI

1 reference

30 July 2017

1 reference

PubMed ID

10987092