Cellular senescence and the senescent secretory phenotype: therapeutic opportunities (Q34035882)

30 July 2017

title

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities (English)

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30 July 2017

1 reference

1 reference

4

Judith Campisi

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30 July 2017

3

Jan van Deursen

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30 July 2017

Tamara Tchkonia

1

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30 July 2017

Yi Zhu

series ordinal

2

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30 July 2017

James L Kirkland

series ordinal

5

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30 July 2017

language of work or name

English

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publication date

1 March 2013

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Journal of Clinical Investigation

30 July 2017

published in

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30 July 2017

volume

123

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30 July 2017

issue

3

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30 July 2017

page(s)

966-972

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Immune surveillance of pre-cancerous senescent hepatocytes limits hepatocellular carcinoma development

30 July 2017

cites work

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8

5 July 2018

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Measuring systemic inflammatory regulation in older adults: evidence and utility

5 July 2018

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5 July 2018

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Proteinopathy-induced neuronal senescence: a hypothesis for brain failure in Alzheimer's and other neurodegenerative diseases

5 July 2018

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Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network

5 July 2018

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Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.

5 July 2018

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5 July 2018

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5 July 2018

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Inflammation, coagulation, and the pathway to frailty

5 July 2018

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Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults

5 July 2018

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Cellular senescence, ageing and disease

5 July 2018

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5 July 2018

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5 July 2018

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A transcriptomic analysis of the EK1.Br strain of human fibroblastoid keratocytes: the effects of growth, quiescence and senescence

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Chemokine signaling via the CXCR2 receptor reinforces senescence

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Cellular senescence: when bad things happen to good cells

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Oncogene-Induced Senescence: Putting the Brakes on Tumor Development

5 July 2018

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5 July 2018

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5 July 2018

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Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

5 July 2018

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Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation

5 July 2018

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Inflammatory markers and the risk of coronary heart disease in men and women

5 July 2018

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Ink4a/Arf expression is a biomarker of aging

5 July 2018

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5 July 2018

A flame burning within

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Loss of proliferative capacity and induction of senescence in oxidatively stressed human fibroblasts

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study

5 July 2018

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Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study

5 July 2018

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Interleukin-6 causes endothelial barrier dysfunction via the protein kinase C pathway.

5 July 2018

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Cellular senescence as a tumor-suppressor mechanism

5 July 2018

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C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus

5 July 2018

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Frailty in older adults: evidence for a phenotype

5 July 2018

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White blood cell count: an independent predictor of coronary heart disease mortality among a national cohort

5 July 2018

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Interleukin 6 inhibits proliferation and, in cooperation with an epidermal growth factor receptor autocrine loop, increases migration of T47D breast cancer cells.

5 July 2018

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Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part I--effects of proliferative senescence

5 July 2018

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5 July 2018

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Serum IL-6 level and the development of disability in older persons

5 July 2018

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5 July 2018

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Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.

5 July 2018

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Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence

29 October 2018

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Frailty defined by deficit accumulation and geriatric medicine defined by frailty

29 October 2018

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Real-time in vivo imaging of p16gene expression: a new approach to study senescence stress signaling in living animals

29 October 2018

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An index of self-rated health deficits in relation to frailty and adverse outcomes in older adults.

29 October 2018

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Decreased osteogenesis, increased cell senescence and elevated Dickkopf-1 secretion in human fracture non union stromal cells.

29 October 2018

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Inflammation and frailty in older women.

29 October 2018

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29 October 2018

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Oncogene-induced senescence as an initial barrier in lymphoma development

29 October 2018

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Inflammatory markers and risk of developing type 2 diabetes in women

29 October 2018

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29 October 2018

1 reference

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Inflammatory markers and cardiovascular disease (The Health, Aging and Body Composition [Health ABC] Study).

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582125

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582125

Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582125

Long-Term Risks of Death and Institutionalization of Elderly People in Relation to Deficit Accumulation at Age 70

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582125

Cellular senescence in endothelial cells from atherosclerotic patients is accelerated by oxidative stress associated with cardiovascular risk factors

29 October 2018

1 reference

12 December 2020

In search of Methuselah: estimating the upper limits to human longevity

1 reference

12 December 2020

Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis

1 reference

12 December 2020

The role of chondrocyte senescence in osteoarthritis

1 reference

12 December 2020

A crucial role for adipose tissue p53 in the regulation of insulin resistance

1 reference

12 December 2020

Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly

1 reference

12 December 2020

New insights into oncogenic stress

1 reference

12 December 2020

C-reactive protein, interleukin-6 and tumor necrosis factor alpha as predictors of incident coronary and cardiovascular events and total mortality. A population-based, prospective study

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI64098

1 reference

30 July 2017

1 reference

30 July 2017

1 reference