Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype (Q35378363)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21880712%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

title

Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype (English)

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11 February 2020

0 references

1 reference

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2

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11 February 2020

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Judith Campisi

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11 February 2020

author name string

Jean-Philippe Coppé

1

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11 February 2020

Christopher K Patil

3

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11 February 2020

Adam Freund

4

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11 February 2020

Pierre-Yves Desprez

5

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11 February 2020

language of work or name

English

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publication date

31 August 2011

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Journal of Biological Chemistry

11 February 2020

published in

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11 February 2020

volume

286

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11 February 2020

issue

42

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11 February 2020

page(s)

36396-36403

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p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

11 February 2020

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Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

27 July 2018

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Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.

27 July 2018

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Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence

27 July 2018

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BRAFE600-associated senescence-like cell cycle arrest of human naevi

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Ink4a/Arf expression is a biomarker of aging

27 July 2018

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27 July 2018

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Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

27 July 2018

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27 July 2018

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27 July 2018

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Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts

27 July 2018

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27 July 2018

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27 July 2018

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Suppression of mammary epithelial cell differentiation by the helix-loop-helix protein Id-1.

27 July 2018

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

27 July 2018

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Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network

27 July 2018

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Senescence of activated stellate cells limits liver fibrosis

26 September 2018

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Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network

26 September 2018

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Chemokine signaling via the CXCR2 receptor reinforces senescence

26 September 2018

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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

26 September 2018

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Restoration of p53 function leads to tumour regression in vivo

26 September 2018

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p16INK4a induces an age-dependent decline in islet regenerative potential

26 September 2018

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p16INK4A is a robust in vivo biomarker of cellular aging in human skin.

26 September 2018

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The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms.

26 September 2018

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Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

26 September 2018

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Cell senescence in rat kidneys in vivo increases with growth and age despite lack of telomere shortening.

26 September 2018

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The role of chondrocyte senescence in the pathogenesis of osteoarthritis and in limiting cartilage repair.

26 September 2018

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DNA damage is able to induce senescence in tumor cells in vitro and in vivo.

26 September 2018

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Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging

26 September 2018

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The p53-deficient mouse: a model for basic and applied cancer studies

26 September 2018

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Ink4a/Arf expression is a biomarker of aging

26 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M111.257071

Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M111.257071

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

21 January 2018

1 reference

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Cellular senescence in the pathogenesis of benign prostatic hyperplasia

8 December 2018

1 reference

12 December 2020

Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts

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12 December 2020

A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents

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12 December 2020

Immunohistochemical survey of p16INK4A expression in normal human adult and infant tissues

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12 December 2020

Identifiers

DOI

10.1074/JBC.M111.257071

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21880712%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21880712%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

PubMed publication ID

21880712

1 reference