Pathobiology of NPM-ALK and variant fusion genes in anaplastic large cell lymphoma and other lymphomas (Q34037769)

30 July 2017

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title

Pathobiology of NPM-ALK and variant fusion genes in anaplastic large cell lymphoma and other lymphomas (English)

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30 July 2017

1

Drexler HG

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30 July 2017

2

Gignac SM

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30 July 2017

5

Dirks WG

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30 July 2017

von Wasielewski R

3

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30 July 2017

Werner M

series ordinal

4

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30 July 2017

publication date

1 September 2000

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30 July 2017

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30 July 2017

volume

14

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30 July 2017

issue

9

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30 July 2017

page(s)

1533-1559

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Production of a monoclonal antibody specific for Hodgkin and Sternberg–Reed cells of Hodgkin's disease and a subset of normal lymphoid cells

30 July 2017

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Ki-1 positive large cell lymphoma. A morphologic and immunologic study of 19 cases

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Ki-1-positive large cell lymphoma. A clinicopathologic study of 41 cases

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Anaplastic large cell lymphoma: a distinct molecular pathologic entity: a reappraisal with special reference to p80(NPM/ALK) expression

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Detection of t(2;5) in anaplastic large cell lymphoma: comparison of immunohistochemical studies, FISH, and RT-PCR in paraffin-embedded tissue

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7 January 2021

CD30+ anaplastic large-cell lymphoma, null type, with signet-ring appearance

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7 January 2021

Sarcomatoid variant of anaplastic large-cell Ki-1 lymphoma

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7 January 2021

Neutrophil-rich, Ki-1-positive anaplastic large-cell malignant lymphoma

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7 January 2021

Malignant histiocytosis. Histologic, cytochemical, chromosomal, and molecular data with a nosologic discussion

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7 January 2021

Malignant histiocytosis: a reassessment of cases formerly classified as histiocytic neoplasms and review of the literature

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Anaplastic large cell lymphoma, CD30/Ki-1 positive, expressing the CD15/Leu-M1 antigen. Immunohistochemical and morphological relationships to Hodgkin's disease

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Clinical features of 31 patients with Ki-1 anaplastic large-cell lymphoma

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7 January 2021

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7 January 2021

Long-term prognostic importance of primary Ki-1 (CD30) antigen expression and anaplastic morphology in adult patients with diffuse large-cell lymphoma

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7 January 2021

Clinical features and treatment outcome for children with CD30+ large-cell non-Hodgkin's lymphoma

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7 January 2021

Anaplastic large-cell lymphoma: clinical and prognostic evaluation of 90 adult patients

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7 January 2021

Primary cutaneous CD30-positive large cell lymphoma: definition of a new type of cutaneous lymphoma with a favorable prognosis. A European Multicenter Study of 47 patients

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7 January 2021

CD30 (Ki-1)-positive anaplastic large-cell lymphomas in 13 patients with and 27 patients without human immunodeficiency virus infection: the first comparative clinicopathologic study from a single institution that also includes 80 patients with othe

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7 January 2021

Anaplastic large cell (CD30/Ki-1+) lymphoma in HIV+ patients: clinical and pathological findings in a group of ten patients

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7 January 2021

Report of the committee on structural chromosome changes in neoplasia

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7 January 2021

Chromosomal t(2; 5) and hematological malignancies

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7 January 2021

CD30-positive large cell lymphomas ('Ki-1 lymphoma') are associated with a chromosomal translocation involving 5q35.

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7 January 2021

A translocation involving a specific breakpoint (q35) on chromosome 5 is characteristic of anaplastic large cell lymphoma ('Ki-1 lymphoma').

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7 January 2021

Morphology in Ki-1(CD30)-positive non-Hodgkin's lymphoma is correlated with clinical features and the presence of a unique chromosomal abnormality, t(2;5)(p23;q35)

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7 January 2021

t(2;5) (p23;q35)-A Specific Chromosome Abnormality in Large Cell Anaplastic (Ki-1) Lymphoma.

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7 January 2021

Immunohistochemical, molecular, and cytogenetic analysis of a consecutive series of 20 peripheral T-cell lymphomas and lymphomas of uncertain lineage, including 12 Ki-1 positive lymphomas

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7 January 2021

Cytogenetic analysis of 434 consecutively ascertained specimens of non-Hodgkin's lymphoma: correlations between recurrent aberrations, histology, and exposure to cytotoxic treatment

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7 January 2021

Clonal cytogenetic abnormalities in Hodgkin's disease

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7 January 2021

Recurrent chromosome abnormalities in peripheral T-cell lymphomas

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7 January 2021

Classification of peripheral T-cell lymphomas: cytogenetic findings support the updated Kiel classification

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7 January 2021

Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5)

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7 January 2021

Biological characteristics of chronic eosinophilic leukemia cells with a t(2;5)(p23;q35) translocation

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7 January 2021

Deletion(2)(p23) abnormality in a case of secondary acute myeloid leukemia

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7 January 2021

del(2)(p23): a new recurrent abnormality in acute myeloid leukemia

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7 January 2021

del(2)(p23): A consistent recurrent abnormality in acute myelogenous leukemia

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7 January 2021

A new variant chromosomal translocation t(2;2)(p23;q23) in CD30+/Ki-1+ anaplastic large cell lymphoma

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7 January 2021

t(2;3)(p23;q26) in a patient with AML M2

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7 January 2021

Translocation (2;4)(p23;q25): an additional case of a new recurrent anomaly in acute myeloid leukemia

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7 January 2021

Novel translocation (2;4) with consistent involvement of 2p23 in acute nonlymphocytic leukemia (M2)

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7 January 2021

A novel variant translocation t(2;13) (p23;q34) in Ki-1 large cell anaplastic lymphoma

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7 January 2021

Identification of novel chromosomal rearrangements in acute myelogenous leukemia involving loci on chromosome 2p23, 15q22 and 17q21.

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7 January 2021

Diffuse large cell, B-cell type lymphoma with a novel translocation (2;22)(p23;q11.2)

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7 January 2021

Translocation (1;5)(q32;q35) in CD30+ anaplastic large cell non-Hodgkin lymphona of childhood. A case report

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7 January 2021

Non-Hodgkin’s lymphomas and myeloid disorders: deletions associated with t(2;5) and t(3;5) detected by FISH

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7 January 2021

Translocation (3;5)(q21;q34) in erythroleukemia: a molecular and in situ hybridization study

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7 January 2021

Cytogenetic study of malignant histiocytosis transplanted into nude mice; presence of translocation between chromosomes 5 and 6 and a unique marker (13q+)

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7 January 2021

DEL cell line: a "malignant histiocytosis" CD30+ t(5;6)(q35;p21) cell line

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7 January 2021

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FLT4 Receptor Tyrosine Kinase Gene Mapping to Chromosome Band 5q35 in Relation to the t(2;5), t(5;6), and t(3;5) Translocations

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7 January 2021

Localization of two tyrosine kinase receptor genes with respect to the 5q35 chromosomal breakpoint of Ki-1 lymphoma cell lines

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7 January 2021

ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)

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7 January 2021

Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system

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7 January 2021

Signal transduction by receptors with tyrosine kinase activity

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7 January 2021

t(2;5) translocations in anaplastic large cell lymphomas and Hodgkin's disease

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7 January 2021

Major nucleolar proteins shuttle between nucleus and cytoplasm

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7 January 2021

Isolation and characterization of the human nucleophosmin/B23 (NPM) gene: identification of the YY1 binding site at the 5' enhancer region

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7 January 2021

Down-regulation of nucleophosmin/B23 during retinoic acid-induced differentiation of human promyelocytic leukemia HL-60 cells.

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7 January 2021

Reduced numatrin/B23/nucleophosmin labeling in apoptotic Jurkat T-lymphoblasts

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7 January 2021

A constitutive nucleolar protein identified as a member of the nucleoplasmin family.

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7 January 2021

Molecular variant of the NPM-ALK rearrangement of Ki-1 lymphoma involving a cryptic ALK splice site

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7 January 2021

The t(2;5) in human lymphomas

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7 January 2021

Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis

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7 January 2021

Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity

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7 January 2021

The activated anaplastic lymphoma kinase increases cellular proliferation and oncogene up-regulation in rat 1a fibroblasts.

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7 January 2021

The tyrosine kinase NPM-ALK, associated with anaplastic large cell lymphoma, binds the intracellular domain of the surface receptor CD30 but is not activated by CD30 stimulation

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7 January 2021

Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs

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7 January 2021

The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping

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7 January 2021

Characterization of molecularly cloned human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase

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7 January 2021

Structure and functional relationships in human pur H

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7 January 2021

The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain

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7 January 2021

Role of the TFG N-terminus and coiled-coil domain in the transforming activity of the thyroid TRK-T3 oncogene

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7 January 2021

Characterization and chromosomal mapping of the human TFG gene involved in thyroid carcinoma

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2401878

7 January 2021

Tropomyosin isoforms in nonmuscle cells.

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7 January 2021

A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences

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7 January 2021

Tissue-specific expression of the human tropomyosin gene involved in the generation of the trk oncogene

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7 January 2021

A sequence analysis of the genomic regions involved in the rearrangements between TPM3 and NTRK1 genes producing TRK oncogenes in papillary thyroid carcinomas

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7 January 2021

cDNA cloning, expression pattern, and chromosomal localization of Mlf1, murine homologue of a gene involved in myelodysplasia and acute myeloid leukemia

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7 January 2021

Apoptosis induced by the myelodysplastic syndrome-associated NPM-MLF1 chimeric protein

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2401878

7 January 2021

HLS7, a hemopoietic lineage switch gene homologous to the leukemia-inducing gene MLF1.

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2401878

7 January 2021

cDNA cloning, tissue distribution, and chromosomal localization of myelodysplasia/myeloid leukemia factor 2 (MLF2)

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7 January 2021

Distinct leukemia phenotypes in transgenic mice and different corepressor interactions generated by promyelocytic leukemia variant fusion genes PLZF-RARalpha and NPM-RARalpha

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7 January 2021

The impact of differential binding of wild-type RARalpha, PML-, PLZF- and NPM-RARalpha fusion proteins towards transcriptional co-activator, RIP-140, on retinoic acid responses in acute promyelocytic leukemia

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7 January 2021

Construction of a YAC contig and a STS map spanning at least seven megabasepairs in chromosome 5q34-35.

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7 January 2021

Detection of NPM-ALK DNA rearrangement in CD30 positive anaplastic large cell lymphoma

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7 January 2021

Detection of the NPM-ALK genomic rearrangement of Ki-1 lymphoma and isolation of the involved NPM and ALK introns

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7 January 2021

Biochemical detection of novel anaplastic lymphoma kinase proteins in tissue sections of anaplastic large cell lymphoma.

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7 January 2021

The clinicopathological features of anaplastic large cell lymphomas expressing p80NPM/ALK.

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7 January 2021

Analysis of the t(2;5) (p23;q35) translocation in CD30+ primary cutaneous lymphoproliferative disorders and Hodgkin's disease

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7 January 2021

Practical role of molecular diagnostics in non-Hodgkin's lymphomas

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7 January 2021

Chromosomal abnormalities in nodal and extranodal CD30+ anaplastic large cell lymphomas: infrequent detection of the t(2;5) in extranodal lymphomas.

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7 January 2021

The use of fluorescent in situ hybridization for detection of the t(2;5)(p23;q35) translocation in anaplastic large-cell lymphoma.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401878

7 January 2021

Use of an anti-ALK antibody in the characterization of anaplastic large-cell lymphoma of childhood

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401878

7 January 2021

c-myc mRNA expression and genomic alterations in mantle cell lymphomas and other nodal non-Hodgkin's lymphomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401878

7 January 2021

The t(2;5)-associated p80 NPM/ALK fusion protein in nodal and cutaneous CD30+ lymphoproliferative disorders

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401878

7 January 2021

NPM/ALK gene fusion transcripts identify a distinct subgroup of null type Ki-1 positive anaplastic large cell lymphomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401878

7 January 2021

Detection of the t(2;5)(p23;q35) chromosomal translocation in large B-cell lymphomas other than anaplastic large cell lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401878

7 January 2021

NPM/ALK fusion mRNA expression in Hodgkin and Reed-Sternberg cells is rare but does occur: results from single-cell cDNA analysis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401878

7 January 2021

Large-cell anaplastic lymphoma-specific translocation in Hodgkin's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401878

7 January 2021

Differences in clinical behaviour and immunophenotype between primary cutaneous and primary nodal anaplastic large cell lymphoma of T-cell or null cell phenotype

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401878

7 January 2021

Successful treatment strategy for Ki-1 anaplastic large-cell lymphoma of childhood: a prospective analysis of 62 patients enrolled in three consecutive Berlin-Frankfurt-Munster group studies.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401878

7 January 2021

CD30/Ki-1-positive lymphoproliferative disorders of the skin--clinicopathologic correlation and statistical analysis of 86 cases: a multicentric study from the European Organization for Research and Treatment of Cancer Cutaneous Lymphoma Project Grou

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401878

7 January 2021

Statistical evaluation of diagnostic and prognostic features of CD30+ cutaneous lymphoproliferative disorders: a clinicopathologic study of 65 cases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401878

7 January 2021

The pathogenesis of large cell transformation in cutaneous T-cell lymphoma is not associated with t(2;5)(p23;q35) chromosomal translocation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401878

7 January 2021

Expression of Bcl-2 and Bcl-2-Ig fusion transcripts in normal and neoplastic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401878

7 January 2021

BCL2 translocation frequency rises with age in humans

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401878

7 January 2021

Occurrence of bcl-2 oncogene translocation with increased frequency in the peripheral blood of heavy smokers.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401878

7 January 2021

Detection of the t(2;5)-associated NPM/ALK fusion cDNA in peripheral blood cells of healthy individuals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401878

7 January 2021

The bcl-2 gene, follicular lymphoma, and Hodgkin's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401878

7 January 2021

Role of the bcl-2 oncogene in Hodgkin's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401878

7 January 2021

The t(14;18) translocation in Hodgkin's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401878

7 January 2021

Lymphocyte predominance Hodgkin's disease (nodular paragranuloma)--a bcl-2 negative germinal centre lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401878

7 January 2021

Bcl-2 rearrangement in Hodgkin's disease and reactive lymph nodes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401878

7 January 2021

Low incidence of mbr bcl-2/JH fusion genes in Hodgkin's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401878

7 January 2021

Expression of the bcl-2 oncogene product and chromosomal translocation t(14;18) in Hodgkin's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401878

7 January 2021

Rearrangement of bcl-2 is detectable in Hodgkin's disease by polymerase chain reaction.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401878

7 January 2021

The bcl-2/JH gene rearrangement is undetectable in Hodgkin's lymphomas: results from the German Hodgkin trial

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401878

7 January 2021

Chromosomal abnormalities in patients with Hodgkin's disease: evidence for frequent involvement of the 14q chromosomal region but infrequent bcl-2 gene rearrangement in Reed-Sternberg cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401878

7 January 2021

Detection of specific t(14;18) chromosomal translocations in fixed tissues

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401878

7 January 2021

Involvement of the bcl-2 gene in Hodgkin's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401878

7 January 2021

Molecular analysis of the t(14;18) chromosomal translocation in malignant lymphomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401878

7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2401878

1 reference

Dimensions Publication ID

30 July 2017

1039016993

0 references

1 reference