Mechanistic target of rapamycin complex 2 protects the heart from ischemic damage (Q34039918)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24008870%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

title

Mechanistic target of rapamycin complex 2 protects the heart from ischemic damage (English)

1 reference

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20 February 2020

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1

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20 February 2020

author name string

Mathias H Konstandin

2

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20 February 2020

Shirin Doroudgar

3

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20 February 2020

Haruhiro Toko

4

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20 February 2020

Pearl Quijada

5

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20 February 2020

Shabana Din

6

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20 February 2020

Anya Joyo

7

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20 February 2020

Luis Ornelas

8

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20 February 2020

Kaitleen Samse

9

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20 February 2020

Donna J Thuerauf

10

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20 February 2020

Natalie Gude

11

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20 February 2020

Christopher C Glembotski

12

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20 February 2020

Mark A Sussman

13

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20 February 2020

language of work or name

English

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publication date

5 September 2013

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20 February 2020

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20 February 2020

volume

128

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20 February 2020

page(s)

2132-2144

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20 February 2020

issue

19

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mTOR-dependent cell survival mechanisms

20 February 2020

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5 July 2018

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5 July 2018

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5 July 2018

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Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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mTORC2 is required for proliferation and survival of TSC2-null cells

5 July 2018

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Nucleolar stress is an early response to myocardial damage involving nucleolar proteins nucleostemin and nucleophosmin

5 July 2018

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Akt, FoxO and regulation of apoptosis

5 July 2018

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Differing effects of rapamycin and mTOR kinase inhibitors on protein synthesis

5 July 2018

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Rapamycin treatment augments both protein ubiquitination and Akt activation in pressure-overloaded rat myocardium

5 July 2018

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Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation.

5 July 2018

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Mitochondrial translocation of Nur77 mediates cardiomyocyte apoptosis

5 July 2018

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mTOR: from growth signal integration to cancer, diabetes and ageing

5 July 2018

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The inotropic peptide βARKct improves βAR responsiveness in normal and failing cardiomyocytes through G(βγ)-mediated L-type calcium current disinhibition.

5 July 2018

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mTOR attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy

5 July 2018

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Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer

5 July 2018

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MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice

5 July 2018

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The FoxO family in cardiac function and dysfunction

5 July 2018

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Involvement of phosphoinositide 3-kinase gamma in angiogenesis and healing of experimental myocardial infarction in mice

5 July 2018

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Mammalian target of rapamycin is a critical regulator of cardiac hypertrophy in spontaneously hypertensive rats.

5 July 2018

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Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID Trial), a first-in-human phase 1/2 clinical trial.

5 July 2018

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Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surface

5 July 2018

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PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex

5 July 2018

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The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1

5 July 2018

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Increased expression of a proline-rich Akt substrate (PRAS40) in human copper/zinc-superoxide dismutase transgenic rats protects motor neurons from death after spinal cord injury

5 July 2018

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PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

5 July 2018

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Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

5 July 2018

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Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

5 July 2018

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

5 July 2018

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Modulation of proline-rich akt substrate survival signaling pathways by oxidative stress in mouse brains after transient focal cerebral ischemia

5 July 2018

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Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor

5 July 2018

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Identification of a proline-rich Akt substrate as a 14-3-3 binding partner

5 July 2018

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Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration

5 July 2018

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PIM1-activated PRAS40 regulates radioresistance in non-small cell lung cancer cells through interplay with FOXO3a, 14-3-3 and protein phosphatases.

5 July 2018

1 reference

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Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice.

28 October 2018

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Beneficial effects of Mammalian target of rapamycin inhibition on left ventricular remodeling after myocardial infarction

28 October 2018

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Pim-1 regulates cardiomyocyte survival downstream of Akt.

28 October 2018

1 reference

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Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload

28 October 2018

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Rapamycin prevents thyroid hormone-induced cardiac hypertrophy

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24008870

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1161/CIRCULATIONAHA.113.003638

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24008870%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24008870%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

1 reference