PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex (Q24316314)

GOA release 2020-03-11

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Carol MacKintosh

4

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Christopher G. Proud

object named as

Christopher G Proud

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author name string

Bruno D Fonseca

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Ewan M Smith

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Vivian H-Y Lee

Journal of Biological Chemistry

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language of work or name

English

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publication date

24 August 2007

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published in

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volume

282

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issue

34

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page(s)

24514-24

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cites work

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Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

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The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif

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Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

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Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes.

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Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins

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DNA-damaging agents cause inactivation of translational regulators linked to mTOR signalling

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The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization

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Simian virus 40 small tumor antigen activates AKT and telomerase and induces anchorage-independent growth of human epithelial cells

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Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

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Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

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PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

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The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1

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Protein kinase A phosphorylation of human phosphodiesterase 3B promotes 14-3-3 protein binding and inhibits phosphatase-catalyzed inactivation

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Rheb binds and regulates the mTOR kinase

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Rheb fills a GAP between TSC and TOR.

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PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding

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The 14-3-3 proteins positively regulate rapamycin-sensitive signaling

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Different roles for the TOS and RAIP motifs of the translational regulator protein 4E-BP1 in the association with raptor and phosphorylation by mTOR in the regulation of cell size

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PRAS40 deregulates apoptosis in malignant melanoma

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Identifiers

DOI

10.1074/JBC.M704406200

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Consolidated OpenCitations Corpus – April 2017

1812768

1812768

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference