The N-terminal, polybasic region is critical for prion protein neuroprotective activity (Q34043470)

30 July 2017

title

The N-terminal, polybasic region is critical for prion protein neuroprotective activity (English)

1 reference

30 July 2017

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Emiliano Biasini

4

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David A Harris

object named as

David A Harris

5

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author name string

Jessie A Turnbaugh

1

1 reference

30 July 2017

Laura Westergard

2

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30 July 2017

Ursula Unterberger

3

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30 July 2017

language of work or name

English

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publication date

29 September 2011

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30 July 2017

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30 July 2017

volume

6

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30 July 2017

issue

9

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30 July 2017

page(s)

e25675

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Creative Commons Attribution 4.0 International

30 July 2017

copyright license

start time

29 September 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

A nine amino acid domain is essential for mutant prion protein toxicity

1 reference

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The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

5 July 2018

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An N-terminal polybasic domain and cell surface localization are required for mutant prion protein toxicity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183058

Anionic phospholipid interactions of the prion protein N terminus are minimally perturbing and not driven solely by the octapeptide repeat domain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183058

Interaction between human prion protein and amyloid-beta (Abeta) oligomers: role OF N-terminal residues

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183058

Axonal prion protein is required for peripheral myelin maintenance

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183058

Structure of the Flexible Amino-Terminal Domain of Prion Protein Bound to a Sulfated Glycan

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183058

The alpha-secretase-derived N-terminal product of cellular prion, N1, displays neuroprotective function in vitro and in vivo

5 July 2018

1 reference

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Antimicrobial activity of human prion protein is mediated by its N-terminal region

5 July 2018

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Prion protein region 23-32 interacts with tubulin and inhibits microtubule assembly

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183058

Pathologic prion protein infects cells by lipid-raft dependent macropinocytosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183058

Prion protein lacks robust cytoprotective activity in cultured cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183058

Stress-protective signalling of prion protein is corrupted by scrapie prions

5 July 2018

1 reference

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Dominant-negative effects of the N-terminal half of prion protein on neurotoxicity of prion protein-like protein/doppel in mice

5 July 2018

1 reference

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Prion protein with an octapeptide insertion has impaired neuroprotective activity in transgenic mice

5 July 2018

1 reference

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Lethal recessive myelin toxicity of prion protein lacking its central domain

5 July 2018

1 reference

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Assigning functions to distinct regions of the N-terminus of the prion protein that are involved in its copper-stimulated, clathrin-dependent endocytosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183058

Cellular prion protein inhibits proapoptotic Bax conformational change in human neurons and in breast carcinoma MCF-7 cells

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183058

Mammalian prion protein suppresses Bax-induced cell death in yeast

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183058

Prion protein prevents human breast carcinoma cell line from tumor necrosis factor alpha-induced cell death

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183058

The mechanism of internalization of glycosylphosphatidylinositol-anchored prion protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183058

Cell-surface prion protein interacts with glycosaminoglycans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183058

Identification of interaction domains of the prion protein with its 37-kDa/67-kDa laminin receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183058

Prion protein protects human neurons against Bax-mediated apoptosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183058

The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183058

Two different neurodegenerative diseases caused by proteins with similar structures

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183058

Onset of ataxia and Purkinje cell loss in PrP null mice inversely correlated with Dpl level in brain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183058

A monomer-dimer equilibrium of a cellular prion protein (PrPC) not observed with recombinant PrP.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183058

Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183058

Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183058

Prion protein-deficient cells show altered response to oxidative stress due to decreased SOD-1 activity.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183058

A 60-kDa prion protein (PrP) with properties of both the normal and scrapie-associated forms of PrP.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183058

Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183058

129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal

5 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0025675

Lack of prion protein expression results in a neuronal phenotype sensitive to stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0025675

Prions prevent neuronal cell-line death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0025675

Neonatal lethality in transgenic mice expressing prion protein with a deletion of residues 105-125.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0025675

Loss of cerebellar Purkinje cells in aged mice homozygous for a disrupted PrP gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0025675

Deletion of N-terminal residues 23-88 from prion protein (PrP) abrogates the potential to rescue PrP-deficient mice from PrP-like protein/doppel-induced Neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0025675

Identification of the heparan sulfate binding sites in the cellular prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0025675

A vector for expressing foreign genes in the brains and hearts of transgenic mice

21 January 2018

2 references

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0025675

21 January 2018

https://pubmed.ncbi.nlm.nih.gov/21980526

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Neurological illness in transgenic mice expressing a prion protein with an insertional mutation.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0025675

Dominant roles of the polybasic proline motif and copper in the PrP23-89-mediated stress protection response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0025675

Truncated Prion Protein and Doppel Are Myelinotoxic in the Absence of Oligodendrocytic PrPC

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0025675

The low-density lipoprotein receptor-related protein 1 (LRP1) mediates the endocytosis of the cellular prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0025675

Essential role of the prion protein N terminus in subcellular trafficking and half-life of cellular prion protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0025675

Relevance of the N-terminal NLS-like sequence of the prion protein for membrane perturbation effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0025675

Identification of cryptic nuclear localization signals in the prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0025675

The N-terminal domain of a glycolipid-anchored prion protein is essential for its endocytosis via clathrin-coated pits

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21980526

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0025675

1 reference

release_jtjfcxxttbgkngwo6m5ygdsk7m

30 July 2017

0 references

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/jtjfcxxttbgkngwo6m5ygdsk7m

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMC publication ID

3183058

1 reference

30 July 2017

1 reference