Cellular prion protein inhibits proapoptotic Bax conformational change in human neurons and in breast carcinoma MCF-7 cells (Q40431685)

20 September 2017

Cellular prion protein inhibits proapoptotic Bax conformational change in human neurons and in breast carcinoma MCF-7 cells (English)

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20 September 2017

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Roucou X

1

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20 September 2017

Giannopoulos PN

2

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20 September 2017

Zhang Y

3

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20 September 2017

Jodoin J

4

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20 September 2017

Goodyer CG

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20 September 2017

LeBlanc A

6

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20 September 2017

1 July 2005

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Cell Death & Differentiation

20 September 2017

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20 September 2017

12

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20 September 2017

7

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20 September 2017

783-795

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https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401629

20 September 2017

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cites work

Prions prevent neuronal cell-line death.

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7 January 2021

Lack of prion protein expression results in a neuronal phenotype sensitive to stress

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7 January 2021

Stress-inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotection

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7 January 2021

Cellular prion protein transduces neuroprotective signals

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions.

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7 January 2021

Prion protein prevents human breast carcinoma cell line from tumor necrosis factor alpha-induced cell death

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Prion protein protects human neurons against Bax-mediated apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Cytosolic prion protein is not toxic and protects against Bax-mediated cell death in human primary neurons

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Widespread elimination of naturally occurring neuronal death in Bax-deficient mice

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

BAX is required for neuronal death after trophic factor deprivation and during development

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Mitochondria as the central control point of apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Breaking the mitochondrial barrier

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

BAR: An apoptosis regulator at the intersection of caspases and Bcl-2 family proteins

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7 January 2021

Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast

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7 January 2021

JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Ku70 suppresses the apoptotic translocation of Bax to mitochondria.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Humanin peptide suppresses apoptosis by interfering with Bax activation

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Human alphaA- and alphaB-crystallins bind to Bax and Bcl-X(S) to sequester their translocation during staurosporine-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

BID: a novel BH3 domain-only death agonist

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7 January 2021

Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Increased production of 4 kDa amyloid beta peptide in serum deprived human primary neuron cultures: possible involvement of apoptosis

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7 January 2021

Selective and protracted apoptosis in human primary neurons microinjected with active caspase-3, -6, -7, and -8.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

p75 neurotrophin receptor protects primary cultures of human neurons against extracellular amyloid beta peptide cytotoxicity.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Nonionic detergents induce dimerization among members of the Bcl-2 family

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Bcl-2 inhibits a Fas-induced conformational change in the Bax N terminus and Bax mitochondrial translocation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

SM-20 is a novel mitochondrial protein that causes caspase-dependent cell death in nerve growth factor-dependent neurons

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Evidence of a novel event during neuronal death: development of competence-to-die in response to cytoplasmic cytochrome c

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Proteasomes and ubiquitin are involved in the turnover of the wild-type prion protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Wild-type PrP and a mutant associated with prion disease are subject to retrograde transport and proteasome degradation

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Proteasomal Degradation and N-terminal Protease Resistance of the Codon 145 Mutant Prion Protein

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Protection from cytosolic prion protein toxicity by modulation of protein translocation

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Cytosolic prion protein in neurons.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Bax oligomerization in mitochondrial membranes requires tBid (caspase-8-cleaved Bid) and a mitochondrial protein.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Analysis of interaction sites in homo- and heteromeric complexes containing Bcl-2 family members and the cellular prion protein.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

The cellular prion protein (PrP) selectively binds to Bcl-2 in the yeast two-hybrid system

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

BAX translocation is a critical event in neuronal apoptosis: regulation by neuroprotectants, BCL-2, and caspases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Bcl-2 on the endoplasmic reticulum regulates Bax activity by binding to BH3-only proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Ectopic expression of Bcl-2 and Bcl-xL inhibits apoptosis induced by TNF-related apoptosis-inducing ligand (TRAIL) through suppression of caspases-8, 7, and 3 and BID cleavage in human acute myelogenous leukemia cell line HL-60.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Bcl-2 family member Bfl-1/A1 sequesters truncated bid to inhibit is collaboration with pro-apoptotic Bak or Bax

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

BCL-2 Selectively Interacts with the BID-induced Open Conformer of BAK, Inhibiting BAK Auto-oligomerization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Neuroprotective functions of prion protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Inactivation of caspase-8 on mitochondria of Bcl-xL-expressing MCF7-Fas cells: role for the bifunctional apoptosis regulator protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Inhibition of Bid-induced apoptosis by Bcl-2. tBid insertion, Bax translocation, and Bax/Bak oligomerization suppressed

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Early transitory rise in intracellular pH leads to Bax conformation change during ceramide-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Regulation of intracellular pH mediates Bax activation in HeLa cells treated with staurosporine or tumor necrosis factor-alpha

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Conformational control of Bax localization and apoptotic activity by Pro168.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Withdrawal of IL-7 induces Bax translocation from cytosol to mitochondria through a rise in intracellular pH.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Bax-induced cytochrome C release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401629

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4401629

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Dimensions Publication ID

20 September 2017

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