p38 mitogen-activated protein kinase promotes cell survival in response to DNA damage but is not required for the G(2) DNA damage checkpoint in human cancer cells (Q34045669)

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English	p38 mitogen-activated protein kinase promotes cell survival in response to DNA damage but is not required for the G(2) DNA damage checkpoint in human cancer cells	scientific article

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4 February 2020

p38 mitogen-activated protein kinase promotes cell survival in response to DNA damage but is not required for the G(2) DNA damage checkpoint in human cancer cells (English)

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4 February 2020

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Greg Tucker-Kellogg

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4 February 2020

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4 February 2020

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Mark S Phong

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4 February 2020

Robert D Van Horn

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4 February 2020

Shuyu Li

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4 February 2020

Xiang S Ye

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1 June 2010

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4 February 2020

Molecular and Cellular Biology

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3816-3826

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15

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4 February 2020

The p38alpha kinase plays a central role in inflammation

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Acidic preconditioning protects endothelial cells against apoptosis through p38- and Akt-dependent Bcl-xL overexpression.

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Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1.

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Expanded roles for Chk1 in genome maintenance

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G2/M checkpoint stringency is a key parameter in the sensitivity of AML cells to genotoxic stress.

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The G2 p38-mediated stress-activated checkpoint pathway becomes attenuated in transformed cells

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The selectivity of protein kinase inhibitors: a further update

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Chk1 instability is coupled to mitotic cell death of p53-deficient cells in response to virus-induced DNA damage signaling

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Inhibition of p38 mitogen-activated protein kinase-induced apoptosis in cultured mature oligodendrocytes using SB202190 and SB203580.

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5 July 2018

p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage

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Application of laser-scanning fluorescence microplate cytometry in high content screening

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Activation of p38 MAP kinase by DNA double-strand breaks in V(D)J recombination induces a G2/M cell cycle checkpoint

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A novel role of p38 alpha MAPK in mitotic progression independent of its kinase activity

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Small molecule p38 inhibitors: novel structural features and advances from 2002-2005.

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Mitotic requirement for aurora A kinase is bypassed in the absence of aurora B kinase

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A small molecule-kinase interaction map for clinical kinase inhibitors

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MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation

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Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase

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p38 MAPK mediates TNF-induced apoptosis in endothelial cells via phosphorylation and downregulation of Bcl-x(L).

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Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents

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Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

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The p38 signal transduction pathway: activation and function

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An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage

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Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

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1 reference

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Cooperative function of Chk1 and p38 pathways in activating G2 arrest following exposure to temozolomide

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p38MAPK inhibitor SB203580 sensitizes human SNU-C4 colon cancer cells to exisulind-induced apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20516219

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.00949-09

1 reference

Europe PubMed Central

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4 February 2020

1 reference

Europe PubMed Central

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4 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20516219%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

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