DOCK8 regulates protective immunity by controlling the function and survival of RORγt+ ILCs (Q34055620)

30 July 2017

DOCK8 regulates protective immunity by controlling the function and survival of RORγt+ ILCs (English)

1 reference

30 July 2017

Ahmet Eken

2

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author name string

Akhilesh K Singh

1

1 reference

30 July 2017

Mallory Fry

3

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30 July 2017

Estelle Bettelli

4

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30 July 2017

Mohamed Oukka

5

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30 July 2017

language of work or name

English

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publication date

5 August 2014

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30 July 2017

Nature Communications

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30 July 2017

5

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30 July 2017

4603

1 reference

https://scigraph.springernature.com/pub.10.1038/ncomms5603

30 July 2017

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cites work

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DOCK8 is critical for the survival and function of NKT cells

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Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens

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The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway

5 July 2018

1 reference

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Dedicator of cytokinesis 8 interacts with talin and Wiskott-Aldrich syndrome protein to regulate NK cell cytotoxicity

5 July 2018

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Innate lymphoid cells--a proposal for uniform nomenclature

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Distinct requirements for T-bet in gut innate lymphoid cells

5 July 2018

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Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria

5 July 2018

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5 July 2018

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The transcription factor T-bet regulates intestinal inflammation mediated by interleukin-7 receptor+ innate lymphoid cells.

5 July 2018

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DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation

5 July 2018

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Additional diverse findings expand the clinical presentation of DOCK8 deficiency

5 July 2018

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DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses

5 July 2018

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Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation

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5 July 2018

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The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells

5 July 2018

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AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch

5 July 2018

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Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles

5 July 2018

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Role of the commensal microbiota in normal and pathogenic host immune responses

5 July 2018

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DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice

5 July 2018

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Lymphotoxin controls the IL-22 protection pathway in gut innate lymphoid cells during mucosal pathogen challenge.

5 July 2018

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Identity, regulation and in vivo function of gut NKp46+RORγt+ and NKp46+RORγt- lymphoid cells

5 July 2018

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Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22.

5 July 2018

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CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut.

5 July 2018

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The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling.

5 July 2018

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Regulated expression of nuclear receptor RORγt confers distinct functional fates to NK cell receptor-expressing RORγt(+) innate lymphocytes

5 July 2018

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IL-12 initiates tumor rejection via lymphoid tissue-inducer cells bearing the natural cytotoxicity receptor NKp46.

5 July 2018

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Dedicator of cytokinesis 8 (DOCK8) deficiency

5 July 2018

1 reference

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Shared dependence on the DNA-binding factor TOX for the development of lymphoid tissue-inducer cell and NK cell lineages

5 July 2018

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Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology.

5 July 2018

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Immune adaptations that maintain homeostasis with the intestinal microbiota

5 July 2018

1 reference

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IL-7 and IL-15 independently program the differentiation of intestinal CD3-NKp46+ cell subsets from Id2-dependent precursors

5 July 2018

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Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome

5 July 2018

1 reference

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Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135384

Combined immunodeficiency associated with DOCK8 mutations

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135384

Interleukin-22-producing natural killer cells and lymphoid tissue inducer-like cells in mucosal immunity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135384

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135384

Cutting edge: IL-23 receptor gfp reporter mice reveal distinct populations of IL-17-producing cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135384

Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135384

RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135384

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135384

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135384

Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135384

Transforming growth factor-beta induces development of the T(H)17 lineage

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135384

Host-bacterial mutualism in the human intestine

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135384

Isolation and characterisation of DOCK8, a member of the DOCK180-related regulators of cell morphology

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135384

Clearance of Citrobacter rodentium requires B cells but not secretory immunoglobulin A (IgA) or IgM antibodies.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135384

An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135384

Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135384

Central role for B lymphocytes and CD4+ T cells in immunity to infection by the attaching and effacing pathogen Citrobacter rodentium

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135384

Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135384

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135384

Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135384

Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135384

Inducible lymphoid tissues in the adult gut: recapitulation of a fetal developmental pathway?

5 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5603

RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5603

Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5603

Notch signaling is necessary for adult, but not fetal, development of RORγt(+) innate lymphoid cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5603

The fetal liver counterpart of adult common lymphoid progenitors gives rise to all lymphoid lineages, CD45+CD4+CD3- cells, as well as macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5603

A T-bet gradient controls the fate and function of CCR6-RORγt+ innate lymphoid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5603

21 January 2018

Identifiers

DOI

10.1038/NCOMMS5603

1 reference

Dimensions Publication ID

30 July 2017

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1 reference

30 July 2017

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