PZR coordinates Shp2 Noonan and LEOPARD syndrome signaling in zebrafish and mice (Q34056454)

24865967

30 July 2017

title

PZR coordinates Shp2 Noonan and LEOPARD syndrome signaling in zebrafish and mice (English)

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30 July 2017

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11

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5 June 2020

Piero Giansanti

10

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ORCID Public Data File 2021

author name string

Jeroen Paardekooper Overman

1

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5 June 2020

Jae-Sung Yi

2

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5 June 2020

Monica Bonetti

3

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Matthew Soulsby

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Christian Preisinger

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5 June 2020

Matthew P Stokes

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Li Hui

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Jeffrey C Silva

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John Overvoorde

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5 June 2020

Maria I Kontaridis

12

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5 June 2020

Jeroen den Hertog

13

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Anton M Bennett

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5 June 2020

language of work or name

English

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publication date

27 May 2014

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24865967

Molecular and Cellular Biology

30 July 2017

published in

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volume

34

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issue

15

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5 June 2020

page(s)

2874-2889

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Structural insights into Noonan/LEOPARD syndrome-related mutants of protein-tyrosine phosphatase SHP2 (PTPN11)

5 June 2020

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1 reference

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Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations

5 July 2018

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PTMScan direct: identification and quantification of peptides from critical signaling proteins by immunoaffinity enrichment coupled with LC-MS/MS.

5 July 2018

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Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation.

5 July 2018

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5 July 2018

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Noonan syndrome gain-of-function mutations in NRAS cause zebrafish gastrulation defects

5 July 2018

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5 July 2018

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Phosphatase-dependent and -independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis

5 July 2018

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Noonan, Costello and cardio-facio-cutaneous syndromes: dysregulation of the Ras-MAPK pathway

5 July 2018

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Phosphorylation and localization of protein-zero related (PZR) in cultured endothelial cells

5 July 2018

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Noonan syndrome-associated SHP-2/Ptpn11 mutants enhance SIRPalpha and PZR tyrosyl phosphorylation and promote adhesion-mediated ERK activation

5 July 2018

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Signaling networks assembled by oncogenic EGFR and c-Met

5 July 2018

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Shp2 knockdown and Noonan/LEOPARD mutant Shp2-induced gastrulation defects

5 July 2018

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Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer

5 July 2018

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p53 activation by knockdown technologies

5 July 2018

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Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry

5 July 2018

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Protein tyrosine phosphatase function: the substrate perspective

5 July 2018

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SHP-2 activates signaling of the nuclear factor of activated T cells to promote skeletal muscle growth

5 July 2018

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Noonan syndrome and related disorders: dysregulated RAS-mitogen activated protein kinase signal transduction

5 July 2018

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A probability-based approach for high-throughput protein phosphorylation analysis and site localization

5 July 2018

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Reduced phosphatase activity of SHP-2 in LEOPARD syndrome: consequences for PI3K binding on Gab1

5 July 2018

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PTPN11 (Shp2) mutations in LEOPARD syndrome have dominant negative, not activating, effects

5 July 2018

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Diversity and functional consequences of germline and somatic PTPN11 mutations in human disease

5 July 2018

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Noonan syndrome and related disorders: genetics and pathogenesis

5 July 2018

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Fyn/Yes and non-canonical Wnt signalling converge on RhoA in vertebrate gastrulation cell movements

5 July 2018

1 reference

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Immunoaffinity profiling of tyrosine phosphorylation in cancer cells

5 July 2018

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Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

5 July 2018

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SHP-2 positively regulates myogenesis by coupling to the Rho GTPase signaling pathway

5 July 2018

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Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment

5 July 2018

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The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

5 July 2018

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Identification of a variant form of PZR lacking immunoreceptor tyrosine-based inhibitory motifs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135572

Redox-regulated rotational coupling of receptor protein-tyrosine phosphatase alpha dimers

5 July 2018

1 reference

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Novel mesenchymal and haematopoietic cell isoforms of the SHP-2 docking receptor, PZR: identification, molecular cloning and effects on cell migration

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135572

Cell surface glycoprotein PZR is a major mediator of concanavalin A-induced cell signaling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135572

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135572

Dissecting the interaction of SHP-2 with PZR, an immunoglobulin family protein containing immunoreceptor tyrosine-based inhibitory motifs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135572

The Shp-2 tyrosine phosphatase activates the Src tyrosine kinase by a non-enzymatic mechanism

5 July 2018

1 reference

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Morphogenetic movements at gastrulation require the SH2 tyrosine phosphatase Shp2.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135572

Purification and cloning of PZR, a binding protein and putative physiological substrate of tyrosine phosphatase SHP-2

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135572

Crystal structure of the tyrosine phosphatase SHP-2

5 July 2018

1 reference

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Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2.

5 July 2018

1 reference

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Structure of the zebrafish snail1 gene and its expression in wild-type, spadetail and no tail mutant embryos

5 July 2018

1 reference

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5 July 2018

1 reference

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Regulation of the Src tyrosine kinase and Syp tyrosine phosphatase by their cellular association.

5 July 2018

1 reference

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corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso

5 July 2018

1 reference

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RPTPalpha and PTPepsilon signaling via Fyn/Yes and RhoA is essential for zebrafish convergence and extension cell movements during gastrulation

5 July 2018

1 reference

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The murine ortholog of the SHP-2 binding molecule, PZR accelerates cell migration on fibronectin and is expressed in early embryo formation.

28 October 2018

1 reference

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28 October 2018

1 reference

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28 October 2018

1 reference

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Structural and functional effects of disease-causing amino acid substitutions affecting residues Ala72 and Glu76 of the protein tyrosine phosphatase SHP-2

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24865967

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MCB.00135-14

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5 June 2020

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5 June 2020

24865967

1 reference

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