P53 null mice: damaging the hypothesis? (Q34056655)

30 July 2017

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title

P53 null mice: damaging the hypothesis? (English)

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30 July 2017

Sansom OJ

1

1 reference

PubMed ID

11024475

30 July 2017

Clarke AR

series ordinal

2

1 reference

PubMed ID

11024475

30 July 2017

language of work or name

English

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publication date

1 September 2000

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30 July 2017

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30 July 2017

452

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30 July 2017

149-162

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30 July 2017

2

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Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies

30 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Mdm2 promotes the rapid degradation of p53

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Apoptosis in carcinogenesis: the role of p53.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

The dual role model for p53 in maintaining genomic integrity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Commitment to senescence: A model for the finite and infinite growth of diploid and transformed human fibroblasts in culture

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Tumor spectrum analysis in p53-mutant mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Clinical implications of the p53 tumor-suppressor gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Mouse models dissect the role of p53 in cancer and development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

The role of p53 in tumour suppression: lessons from mouse models

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Effects of p53 mutation on tumor progression: recent insights from mouse tumor models

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Effects of genetic background on tumorigenesis in p53-deficient mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Spontaneous Testicular Teratomas in an Inbred Strain of Mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Cancer. p53, guardian of the genome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Apoptotic repair of genotoxic tissue damage and the role of p53 gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Is aging as complex as it would appear? New perspectives in aging research

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Mismatch repair in replication fidelity, genetic recombination, and cancer biology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Mice with reduced levels of p53 protein exhibit the testicular giant-cell degenerative syndrome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

p53 in embryonic development: maintaining a fine balance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

High-frequency developmental abnormalities in p53-deficient mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

A subset of p53-deficient embryos exhibit exencephaly

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Female embryonic lethality in mice nullizygous for both Msh2 and p53

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

No female embryonic lethality in mice nullizygous for Msh2 and p53

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

p53-dependent apoptosis suppresses radiation-induced teratogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

p53, mutation frequency and apoptosis in the murine small intestine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

P53-dependent and -independent links between DNA-damage, apoptosis and mutation frequency in ES cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Clonal overexpression of metallothionein is induced by somatic mutation in morphologically normal colonic mucosa

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Estimation of mutation frequencies in normal mammalian cells and the development of cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

A clonal marker induced by mutation in mouse intestinal epithelium

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

A comparison of the effects of diverse mutagens at the lacZ transgene and Dlb-1 locus in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Spontaneous mutation frequencies and spectra in p53 (+/+) and p53 (-/-) mice: a test of the 'guardian of the genome' hypothesis in the Big Blue transgenic mouse mutation detection system.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Methylation of CpG dinucleotides in the lacI gene of the Big Blue transgenic mouse

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Application of galactose-sensitiveE.colistrains as selective hosts for LacZ−plasmids

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

The accumulation and persistence of somatic mutations in vivo

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Age dependent selection against HPRT deficient T lymphocytes in the HPRT+/- heterozygous mouse.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Tissues of MSH2-deficient mice demonstrate hypermutability on exposure to a DNA methylating agent.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

p53 deficiency does not affect the accumulation of point mutations in a transgene target

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Thymocyte apoptosis induced by p53-dependent and independent pathways.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

p53 is required for radiation-induced apoptosis in mouse thymocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Absence of p53 permits propagation of mutant cells following genotoxic damage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Apoptosis in small intestinal epithelial from p53-null mice: evidence for a delayed, p53-independent G2/M-associated cell death after gamma-irradiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

A comprehensive study of the radiobiological response of the murine (BDF1) small intestine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Regulation and significance of apoptosis in the stem cells of the gastrointestinal epithelium

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

The intestinal epithelial stem cell: the mucosal governor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Deduction of the clonogen content of intestinal crypts: a direct comparison of two-dose and multiple-dose methodologies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Clonogen content of intestinal crypts: its deduction using a microcolony assay on whole mount preparations and its dependence on radiation dose

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

p53 deficiency sensitizes clonogenic cells to irradiation in the large but not the small intestine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

DNA damage tolerance, mismatch repair and genome instability

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

In vivo administration of O(6)-benzylguanine does not influence apoptosis or mutation frequency following DNA damage in the murine intestine, but does inhibit P450-dependent activation of dacarbazine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Effects of p53 mutations on apoptosis in mouse intestinal and human colonic adenomas

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Increased tumor proliferation and genomic instability without decreased apoptosis in MMTV-ras mice deficient in p53

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

p53-dependent apoptosis suppresses tumor growth and progression in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

p53-dependent cell cycle control: response to genotoxic stress

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Insights into cancer from transgenic mouse models

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

Expression of a p53 mutant in the epidermis of transgenic mice accelerates chemical carcinogenesis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900089-0

10.1016/S0027-5107(00)00089-0

7 January 2021

Identifiers

DOI

1 reference

30 July 2017

1 reference

PubMed ID

11024475