Tissues of MSH2-deficient mice demonstrate hypermutability on exposure to a DNA methylating agent. (Q35795316)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9448296%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

title

Tissues of MSH2-deficient mice demonstrate hypermutability on exposure to a DNA methylating agent (English)

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9 November 2019

2

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9 November 2019

author name string

S E Andrew

1

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9 November 2019

B S Cheng

3

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9 November 2019

A Francis

4

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9 November 2019

J Penney

5

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9 November 2019

A H Reitmair

6

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9 November 2019

T W Mak

7

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9 November 2019

F R Jirik

8

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9 November 2019

language of work or name

English

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publication date

1 February 1998

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9 November 2019

number of pages

5

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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9 November 2019

volume

95

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9 November 2019

issue

3

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9 November 2019

page(s)

1126-1130

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Base transitions dominate the mutational spectrum of a transgenic reporter gene in MSH2 deficient mice

9 November 2019

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Elevated levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pms2

27 July 2018

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A 3 milliTesla 60 Hz magnetic field is neither mutagenic nor co-mutagenic in the presence of menadione and MNU in a transgenic rat cell line

27 July 2018

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A novel lacI transgenic mutation-detection system and its application to establish baseline mutation frequencies in the scid mouse.

27 July 2018

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Lessons from hereditary colorectal cancer

27 July 2018

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Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer.

27 July 2018

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Does increased endogenous formation of N-nitroso compounds in the human colon explain the association between red meat and colon cancer?

27 July 2018

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27 July 2018

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Specificity of mutations induced by N-methyl-N-nitrosourea in a cDNA of the hprt gene

27 July 2018

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Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

27 July 2018

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The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

27 July 2018

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Incision at DNA G.T mispairs by extracts of mammalian cells occurs preferentially at cytosine methylation sites and is not targeted by a separate G.T binding reaction

27 July 2018

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Mutations of two PMS homologues in hereditary nonpolyposis colon cancer

27 July 2018

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Development of a rat cell line containing stably integrated copies of a lambda/lacI shuttle vector

27 July 2018

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Transgenic systems for in vivo mutation analysis

27 July 2018

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Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

27 July 2018

1 reference

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Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis

27 July 2018

1 reference

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GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells

27 July 2018

1 reference

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Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells

27 July 2018

1 reference

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MSH2 deficient mice are viable and susceptible to lymphoid tumours

27 July 2018

1 reference

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Identification of mismatch repair genes and their role in the development of cancer

27 July 2018

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Mutagenicity of N-nitroso bile acid conjugates in Salmonella typhimurium and diploid human lymphoblasts.

27 July 2018

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Nearest neighbor affects G:C to A:T transitions induced by alkylating agents

27 July 2018

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Concomitant K- and N-ras gene point mutations in clonal murine lymphoma

27 July 2018

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Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system

27 July 2018

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Mammalian synthesis of nitrite, nitrate, nitric oxide, and N-nitrosating agents

27 July 2018

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Influence of dietary protein and gut microflora on endogenous synthesis of nitrate and N-nitrosamines in the rat.

27 July 2018

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ras oncogenes in human cancer: a review

27 July 2018

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Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

27 July 2018

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Mutational specificity of alkylating agents and the influence of DNA repair

27 July 2018

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Why do O6-alkylguanine and O4-alkylthymine miscode? The relationship between the structure of DNA containing O6-alkylguanine and O4-alkylthymine and the mutagenic properties of these bases

27 July 2018

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Exposure of humans to endogenous N-nitroso compounds: implications in cancer etiology

27 July 2018

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The use of transgenic mice for short-term, in vivo mutagenicity testing.

27 July 2018

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Site specificity of N-methyl-N-nitrosourea-induced transition mutations in the hprt gene.

27 July 2018

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The detection of alkylation damage in the DNA of human gastrointestinal tissues

27 July 2018

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Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice

27 July 2018

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Self-destruction and tolerance in resistance of mammalian cells to alkylation damage

27 July 2018

1 reference

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Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice

27 July 2018

1 reference

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Loss or somatic mutations of hMSH2 occur in hereditary nonpolyposis colorectal cancers with hMSH2 germline mutations.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18694

An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

25 September 2018

1 reference

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Glutathione-ascorbic acid antioxidant system in animals.

25 September 2018

1 reference

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DNA base changes and alkylation following in vivo exposure of Escherichia coli to N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea

25 September 2018

1 reference

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Mutagenicity of benzo[a]pyrene bay-region sulfonates.

25 September 2018

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Crossref

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Possible Relevance of O–6 Alkylation of Deoxyguanosine to the Mutagenicity and Carcinogenicity of Nitrosamines and Nitrosamides

21 January 2018

1 reference

Crossref

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Detection of O6-methylguanine, O4-methylthymine and O4-ethylthymine in human liver and peripheral blood leukocyte DNA

21 January 2018

1 reference

12 December 2020

Effect of the direction of DNA replication on mutagenesis by N-methyl-N'-nitro-N-nitrosoguanidine in adapted cells of Escherichia coli

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12 December 2020

Protein domain structure influences observed distribution of mutation

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12 December 2020

Mutational specificity of N-methyl-N-nitrosourea in the lacI gene of Escherichia coli

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12 December 2020

ras oncogenes and phenotypic staging in N-methylnitrosourea- and gamma-irradiation-induced thymic lymphomas in C57BL/6J mice

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Identifiers

DOI

10.1073/PNAS.95.3.1126

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9448296%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

0 references

1 reference

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9 November 2019

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