Tautomerism provides a molecular explanation for the mutagenic properties of the anti-HIV nucleoside 5-aza-5,6-dihydro-2'-deoxycytidine (Q34060532)

30 July 2017

Tautomerism provides a molecular explanation for the mutagenic properties of the anti-HIV nucleoside 5-aza-5,6-dihydro-2'-deoxycytidine (English)

1 reference

30 July 2017

2

Bogdan I Fedeles

1 reference

30 July 2017

8

Andrei Tokmakoff

1 reference

30 July 2017

Deyu Li

1

1 reference

30 July 2017

Vipender Singh

3

1 reference

30 July 2017

Chunte Sam Peng

4

1 reference

30 July 2017

Katherine J Silvestre

5

1 reference

30 July 2017

Allison K Simi

6

1 reference

30 July 2017

Jeffrey H Simpson

7

1 reference

30 July 2017

John M Essigmann

9

1 reference

30 July 2017

language of work or name

English

0 references

publication date

28 July 2014

1 reference

Proceedings of the National Academy of Sciences of the United States of America

30 July 2017

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30 July 2017

111

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30 July 2017

E3252-9

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30 July 2017

32

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Direct observation of multiple tautomers of oxythiamine and their recognition by the thiamine pyrophosphate riboswitch

30 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

Extinction of hepatitis C virus by ribavirin in hepatoma cells involves lethal mutagenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

Structure-activity relationships and design of viral mutagens and application to lethal mutagenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

Direct observation of ground-state lactam-lactim tautomerization using temperature-jump transient 2D IR spectroscopy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

Deep sequencing reveals mutagenic effects of ribavirin during monotherapy of hepatitis C virus genotype 1-infected patients

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

Intrinsic immunity against retrotransposons by APOBEC cytidine deaminases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

T-705 (favipiravir) induces lethal mutagenesis in influenza A H1N1 viruses in vitro

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

Identification of Lactam-Lactim Tautomers of Aromatic Heterocycles in Aqueous Solution Using 2D IR Spectroscopy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

Arenaviruses and lethal mutagenesis. Prospects for new ribavirin-based interventions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

AID and Apobec3G haphazard deamination and mutational diversity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

The biased nucleotide composition of the HIV genome: a constant factor in a highly variable virus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

Stochastic simulations suggest that HIV-1 survives close to its error threshold

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

RNA virus genetic robustness: possible causes and some consequences

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

The origin of genetic diversity in HIV-1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

Viral quasispecies evolution

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

Lethal mutagenesis of viruses

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

A review comparing deoxyribonucleoside triphosphate (dNTP) concentrations in the mitochondrial and cytoplasmic compartments of normal and transformed cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

2´-deoxy-5,6-dihydro-5-azacytidine - a less toxic alternative of 2´-deoxy-5-azacytidine: a comparative study of hypomethylating potential

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

Mutation of HIV-1 genomes in a clinical population treated with the mutagenic nucleoside KP1461

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

Exploiting drug repositioning for discovery of a novel HIV combination therapy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

Pathways to extinction: beyond the error threshold

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

The development of antiretroviral therapy and its impact on the HIV-1/AIDS pandemic

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

Current status and challenges of antiretroviral research and therapy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

Therapeutically targeting RNA viruses via lethal mutagenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

Transient two-dimensional IR spectrometer for probing nanosecond temperature-jump kinetics

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

Evolutionary dynamics of HIV-1 and the control of AIDS.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

Viruses as quasispecies: biological implications

5 July 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

5 July 2018

https://api.crossref.org/works/10.1073%2FPNAS.1405635111

KP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

Lethal mutagenesis of HIV.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

Arenavirus extinction through lethal mutagenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

Nucleobases as supramolecular motifs.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

Mutagenesis, genotoxicity, and repair of 1-methyladenine, 3-alkylcytosines, 1-methylguanine, and 3-methylthymine in alkB Escherichia coli

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

5 July 2018

DNA replication fidelity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

G-quartets 40 years later: from 5'-GMP to molecular biology and supramolecular chemistry

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

Tautomeric forms in a polynucleotide helix and their bearing on the structure of DNA.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

Genetical Implications of the Structure of Deoxyribonucleic Acid

5 July 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

5 July 2018

https://api.crossref.org/works/10.1073%2FPNAS.1405635111

Multiple viral genetic analyses detect low-level human immunodeficiency virus type 1 replication during effective highly active antiretroviral therapy

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

Error catastrophe and antiviral strategy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

Quasispecies, error catastrophe, and the antiviral activity of ribavirin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

Identification by UV resonance Raman spectroscopy of an imino tautomer of 5-hydroxy-2'-deoxycytidine, a powerful base analog transition mutagen with a much higher unfavored tautomer frequency than that of the natural residue 2'-deoxycytidine

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

Lethal mutagenesis of HIV with mutagenic nucleoside analogs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

Evidence for tautomerism in nucleic acid base pairs. 1H NMR study of 15N labeled tRNA.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

Complementary base pairing and the origin of substitution mutations

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

HIV cure: controversy, consensus, and a consortium

5 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405635111

The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405635111

Mechanism of action of a novel viral mutagenic covert nucleotide: molecular interactions with HIV-1 reverse transcriptase and host cell DNA polymerases

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405635111

Proton Tunneling in DNA and its Biological Implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405635111

Assays for determining lesion bypass efficiency and mutagenicity of site-specific DNA lesions in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405635111

Self-assembling of cytosine nucleoside into triply-bound dimers in acid media. A comprehensive evaluation of proton-bound pyrimidine nucleosides by electrospray tandem mass spectrometry, X-rays diffractometry, and theoretical calculations

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405635111

Systemic pharmacokinetics and cellular pharmacology of zidovudine in human immunodeficiency virus type 1-infected women and newborn infants

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405635111

Gel-like lyomesophases formed in organic solvents by self-assembled guanine ribbons

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136561

Future prospects for the treatment of rapidly evolving viral pathogens: insights from evolutionary biology

28 October 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405635111

Direct determination of tautomerism in purine derivatives by low-temperature NMR spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405635111

Anharmonic Vibrational Modes of Nucleic Acid Bases Revealed by 2D IR Spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405635111

Transient two-dimensional spectroscopy with linear absorption corrections applied to temperature-jump two-dimensional infrared

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405635111

Mutations caught in the act

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405635111

Pairing of isolated nucleic-acid bases in the absence of the DNA backbone

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405635111

21 January 2018

Identifiers

DOI

10.1073/PNAS.1405635111

1 reference

30 July 2017

0 references

1 reference

30 July 2017

1 reference