Exploiting drug repositioning for discovery of a novel HIV combination therapy (Q34124794)

31 July 2017

title

Exploiting drug repositioning for discovery of a novel HIV combination therapy (English)

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31 July 2017

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Christine L Clouser

1

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31 July 2017

Steven E Patterson

series ordinal

2

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31 July 2017

Louis M Mansky

series ordinal

3

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31 July 2017

language of work or name

English

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publication date

7 July 2010

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31 July 2017

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31 July 2017

volume

84

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31 July 2017

issue

18

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31 July 2017

page(s)

9301-9309

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5-Azacytidine can induce lethal mutagenesis in human immunodeficiency virus type 1.

31 July 2017

cites work

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5 July 2018

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Cellular pharmacology of gemcitabine

5 July 2018

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Pharmacology of 5-Aza-2'-deoxycytidine (decitabine).

5 July 2018

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KP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis

5 July 2018

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Suppression of viral infectivity through lethal defection

5 July 2018

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Drug repositioning: identifying and developing new uses for existing drugs

5 July 2018

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Replication Kinetics for Divergent Type 1 Human Immunodeficiency Viruses Using Quantitative SYBR Green I Real-Time Polymerase Chain Reaction

5 July 2018

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Mutagenesis versus Inhibition in the Efficiency of Extinction of Foot-and-Mouth Disease Virus

5 July 2018

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Lethal mutagenesis of the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV).

5 July 2018

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Development pharmaceutics of microbicide formulations. Part I: preformulation considerations and challenges

5 July 2018

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5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy

5 July 2018

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Efficient Virus Extinction by Combinations of a Mutagen and Antiviral Inhibitors

5 July 2018

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A new mathematical model for relative quantification in real-time RT-PCR

5 July 2018

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Response of foot-and-mouth disease virus to increased mutagenesis: influence of viral load and fitness in loss of infectivity

5 July 2018

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Suppression of replication of multidrug-resistant HIV type 1 variants by combinations of thymidylate synthase inhibitors with zidovudine or stavudine

5 July 2018

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Lethal mutagenesis of HIV with mutagenic nucleoside analogs

5 July 2018

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Indicator cell lines for detection of primary strains of human and simian immunodeficiency viruses

5 July 2018

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Mutagenicity of 5-aza-2'-deoxycytidine is mediated by the mammalian DNA methyltransferase

5 July 2018

1 reference

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Restriction and enhancement of human immunodeficiency virus type 1 replication by modulation of intracellular deoxynucleoside triphosphate pools.

5 July 2018

1 reference

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Low levels of deoxynucleotides in peripheral blood lymphocytes: a strategy to inhibit human immunodeficiency virus type 1 replication

5 July 2018

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Cofactor requirement for human immunodeficiency virus type 1 entry into a CD4-expressing human cell line

5 July 2018

1 reference

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Hypermutagenesis of RNA using human immunodeficiency virus type 1 reverse transcriptase and biased dNTP concentrations

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937626

Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity

5 July 2018

1 reference

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The use of Chinese hamster ovary cells to quantify specific locus mutation and to determine mutagenicity of chemicals. A report of the gene-tox program

5 July 2018

1 reference

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Ribavirin antagonizes inhibitory effects of pyrimidine 2',3'-dideoxynucleosides but enhances inhibitory effects of purine 2',3'-dideoxynucleosides on replication of human immunodeficiency virus in vitro

5 July 2018

1 reference

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2',3'-Dideoxycytidine: regulation of its metabolism and anti-retroviral potency by natural pyrimidine nucleosides and by inhibitors of pyrimidine nucleotide synthesis

5 July 2018

1 reference

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Carcinogenicity and haemoglobin synthesis induction by cytidine analogues

5 July 2018

1 reference

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Inactivation of the HIV LTR by DNA CpG methylation: evidence for a role in latency.

5 July 2018

1 reference

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Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2',2'-difluorodeoxycytidine

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937626

Mutation Frequencies at Defined Single Codon Sites in Vesicular Stomatitis Virus and Poliovirus Can Be Increased Only Slightly by Chemical Mutagenesis

5 July 2018

1 reference

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The effects of dNTP pool imbalances on frameshift fidelity during DNA replication

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937626

Synthesis and biological activity of several amino analogues of thymidine

5 July 2018

1 reference

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Development of a real-time PCR assay using SYBR Green I for provirus load quantification in a murine model of AIDS.

5 July 2018

1 reference

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Pilot phase I-II study on 5-aza-2'-deoxycytidine (Decitabine) in patients with metastatic lung cancer

28 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937626

Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replication

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937626

Cell cycle effects and cellular pharmacology of 5-AZA-2?-deoxycytidine

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937626

Differential effects of 5-azacytidine and 5-azadeoxycytidine on cytotoxicity, DNA-strand breaking and repair of X-ray-induced DNA damage in HeLa cells

28 October 2018

1 reference

12 December 2020

Gemcitabine in leukemia: a phase I clinical, plasma, and cellular pharmacology study

1 reference

12 December 2020

Pharmacokinetics of gemcitabine in Japanese cancer patients: the impact of a cytidine deaminase polymorphism

1 reference

12 December 2020

Action of 2',2'-difluorodeoxycytidine on DNA synthesis

1 reference

12 December 2020

Identifiers

DOI

10.1128/JVI.01006-10

1 reference

31 July 2017

1 reference

31 July 2017

1 reference