Time-resolved in silico modeling of fine-tuned cAMP signaling in platelets: feedback loops, titrated phosphorylations and pharmacological modulation. (Q34060673)

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English	Time-resolved in silico modeling of fine-tuned cAMP signaling in platelets: feedback loops, titrated phosphorylations and pharmacological modulation.	scientific article

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15 January 2020

Time-resolved in silico modeling of fine-tuned cAMP signaling in platelets: feedback loops, titrated phosphorylations and pharmacological modulation (English)

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Thomas Dandekar

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Gaby Wangorsch

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Regina Mark

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Katharina Hubertus

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Marcus Dittrich

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28 October 2011

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BMC Systems Biology

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Antiplatelet drug interactions.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

Regulators of platelet cAMP levels: clinical and therapeutic implications

1 reference

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1 reference

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28 July 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

Protein dynamics in drug combinations: a linear superposition of individual-drug responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

Antiplatelet therapies for the treatment of cardiovascular disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

Protein kinase C-mediated phosphorylation and activation of PDE3A regulate cAMP levels in human platelets.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

Dynamical modeling and multi-experiment fitting with PottersWheel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

Prostacyclin therapies for the treatment of pulmonary arterial hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

Acceleration of cardiovascular disease by a dysfunctional prostacyclin receptor mutation: potential implications for cyclooxygenase-2 inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

A multiscale model of thrombus development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

Overview of PDEs and their regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

Phosphodiesterase 3A binds to 14-3-3 proteins in response to PMA-induced phosphorylation of Ser428.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

Platelet adenylyl cyclase activity: a biological marker for major depression and recent drug use.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

Phosphodiesterases in the vascular system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

Identification of nucleocytoplasmic cycling as a remote sensor in cellular signaling by databased modeling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

Altered phosphodiesterase 3-mediated cAMP hydrolysis contributes to a hypermotile phenotype in obese JCR:LA-cp rat aortic vascular smooth muscle cells: implications for diabetes-associated cardiovascular disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

PKA-dependent activation of PDE3A and PDE4 and inhibition of adenylyl cyclase V/VI in smooth muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

Taming platelets with cyclic nucleotides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

Inhibitors of platelet signal transduction as anti-aggregatory drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

Molecular mechanisms involved in the synergistic activation of soluble guanylyl cyclase by YC-1 and nitric oxide in endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

Membrane localization of cyclic nucleotide phosphodiesterase 3 (PDE3). Two N-terminal domains are required for the efficient targeting to, and association of, PDE3 with endoplasmic reticulum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

Inhibition of human platelet adenylate cyclase activity by adrenaline, thrombin and collagen: analysis and reinterpretation of experimental data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

Adenylyl cyclase 6 is selectively regulated by protein kinase A phosphorylation in a region involved in Galphas stimulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

Platelet adenylyl cyclase activity in alcoholics and subtypes of alcoholics. WHO/ISBRA Study Clinical Centers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

YC-1 inhibited human platelet aggregation through NO-independent activation of soluble guanylate cyclase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

cAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

Regulation of adenylyl cyclase by protein kinase A

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

Activation and selective inhibition of a cyclic AMP-specific phosphodiesterase, PDE-4D3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

cAMP-dependent protein kinase activation lowers hepatocyte cAMP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247139

28 July 2018

Control of platelet activation by cyclic AMP turnover and cyclic nucleotide phosphodiesterase type-3.

1 reference

https://api.crossref.org/works/10.1186%2F1752-0509-5-178

21 January 2018

Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases.

1 reference

https://api.crossref.org/works/10.1186%2F1752-0509-5-178

21 January 2018

New milrinone analogues: in vitro study of structure-activity relationships for positive inotropic effect, antagonism towards endogenous adenosine, and inhibition of cardiac type III phosphodiesterase

1 reference

https://api.crossref.org/works/10.1186%2F1752-0509-5-178

21 January 2018

Analysis and regulation of vasodilator-stimulated phosphoprotein serine 239 phosphorylation in vitro and in intact cells using a phosphospecific monoclonal antibody.

1 reference

https://api.crossref.org/works/10.1186%2F1752-0509-5-178

21 January 2018

A protein phosphorylation-based assay for screening and monitoring of drugs modulating cyclic nucleotide pathways.

1 reference

https://api.crossref.org/works/10.1186%2F1752-0509-5-178

21 January 2018

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1 reference

https://api.crossref.org/works/10.1186%2F1752-0509-5-178

21 January 2018

Inhibition of platelet P2Y12 and alpha2A receptor signaling by cGMP-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1186%2F1752-0509-5-178

21 January 2018

Dynamic modelling and analysis of biochemical networks: mechanism-based models and model-based experiments.

1 reference

https://api.crossref.org/works/10.1186%2F1752-0509-5-178

21 January 2018

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1 reference

https://api.crossref.org/works/10.1186%2F1752-0509-5-178

21 January 2018

Dipyridamole enhances NO/cGMP-mediated vasodilator-stimulated phosphoprotein phosphorylation and signaling in human platelets: in vitro and in vivo/ex vivo studies

1 reference

https://api.crossref.org/works/10.1186%2F1752-0509-5-178

21 January 2018

Ligand specificity and ticlopidine effects distinguish three human platelet ADP receptors

1 reference

https://api.crossref.org/works/10.1186%2F1752-0509-5-178

21 January 2018

Cyclic nucleotide analogs as probes of signaling pathways.

1 reference

https://api.crossref.org/works/10.1186%2F1752-0509-5-178

21 January 2018

Platelet Protein Interactions

1 reference

https://api.crossref.org/works/10.1186%2F1752-0509-5-178

21 January 2018

Characterization of a Novel Interaction Between Vasodilator-Stimulated Phosphoprotein and Abelson Interactor 1 in Human Platelets: A Concerted Computational and Experimental Approach

1 reference

https://api.crossref.org/works/10.1186%2F1752-0509-5-178

21 January 2018

Regulatory mechanisms involved in the control of cyclic adenosine 3‘:5‘-monophosphate phosphodiesterases in myoblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/22034949

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation results in activation of a cAMP phosphodiesterase in human platelets

1 reference

https://pubmed.ncbi.nlm.nih.gov/22034949

12 December 2020

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Activation of the particulate low Km phosphodiesterase of adipocytes by addition of cAMP-dependent protein kinase

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https://pubmed.ncbi.nlm.nih.gov/22034949

12 December 2020

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Synergistic phosphorylation of the focal adhesion-associated vasodilator-stimulated phosphoprotein in intact human platelets in response to cGMP- and cAMP-elevating platelet inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22034949

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid protein kinase A--mediated activation of cyclic AMP-phosphodiesterase by parathyroid hormone in UMR-106 osteoblast-like cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22034949

12 December 2020

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inferred from PubMed ID database lookup

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