Melanocortins and the brain: from effects via receptors to drug targets (Q34060958)

30 July 2017

1 reference

title

Melanocortins and the brain: from effects via receptors to drug targets (English)

1 reference

30 July 2017

Adan RA

1

1 reference

PubMed ID

11033310

30 July 2017

Gispen WH

series ordinal

2

1 reference

PubMed ID

11033310

30 July 2017

language of work or name

English

0 references

publication date

1 September 2000

1 reference

European Journal of Pharmacology

30 July 2017

1 reference

30 July 2017

405

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30 July 2017

1-3

1 reference

30 July 2017

13-24

1 reference

Identification of antagonists for melanocortin MC3, MC4 and MC5 receptors

30 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Characterization of melanocortin receptor ligands on cloned brain melanocortin receptors and on grooming behavior in the rat

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Design of potent linear alpha-melanotropin 4-10 analogues modified in positions 5 and 10

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Peptide-induced excessive grooming in the rat: The role of opiate receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Synthesis and opioid activity of conformationally constrained dynorphin A analogues. 2. Conformational constraint in the "address" sequence

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Cloning and expression of a new member of the melanocyte-stimulating hormone receptor family

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Complete L-alanine scan of neuropeptide Y reveals ligands binding to Y1 and Y2 receptors with distinguished conformations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

The effects of structure-conformation modifications of melanotropin analogs on learning and memory: D-amino acid substituted linear and cyclic analogs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Effects of corticotrophin (ACTH) on recovery of sensorimotor function in the rat: Structure-activity study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Helix-inducing alpha-aminoisobutyric acid in opioid mimetic deltorphin C analogues

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Discovery of an alpha-melanotropin antagonist effective in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Molecular cloning of a novel human melanocortin receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Inhibitory effect of ACTH and related peptides on extinction of conditioned avoidance behavior in rats.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Drug discovery: a historical perspective

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Most of the coding region of rat ACTH beta--LPH precursor gene lacks intervening sequences

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Cloning, expression, and tissue distribution of a fifth melanocortin receptor subtype

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Potency and duration of action of the ACTH 4–9 analog (ORG 2766) as compared to ACTH 4–10 and [D-Phe7] ACTH 4–10 on active and passive avoidance behavior of rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Behavioural changes in animals after intracisternal injection with adrenocorticotrophic hormone and melanocyte-stimulating hormone.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Peptide-induced grooming behavior and caudate nucleus dopamine release

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Adrenocorticotropin/alpha-melanocyte-stimulating hormone (ACTH/MSH)-like peptides modulate adenylate cyclase activity in rat brain slices: evidence for an ACTH/MSH receptor-coupled mechanism.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Evidence for alternate points of attachment for alpha-MSH and its stereoisomer [Nle4, D-Phe7]-alpha-MSH at the melanocortin-1 receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Molecular cloning, expression, and characterization of a fifth melanocortin receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Identification of proopiomelanocortin neurones in rat hypothalamus by in situ cDNA-mRNA hybridization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Binding epitopes for peptide and non-peptide ligands on the NK1 (substance P) receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Opiate antagonists suppress ACTH(1-24)-induced excessive grooming in the rat

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Interaction between acth fragments, brain opiate receptors and morphine-induced analgesia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Molecular cloning and characterization of the rat fifth melanocortin receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Discovery of prototype peptidomimetic agonists at the human melanocortin receptors MC1R and MC4R.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Biological and conformational examination of stereochemical modifications using the template melanotropin peptide, Ac-Nle-c[Asp-His-Phe-Arg-Trp-Ala-Lys]-NH2, on human melanocortin receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

beta-Methylation of the Phe7 and Trp9 melanotropin side chain pharmacophores affects ligand-receptor interactions and prolonged biological activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

alpha-MSH and ACTH4-9 analogue Org 2766 induce a cAMP increase in cultured rat spinal cord cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

The role of calcium and cAMP in the mechanism of action of two melanocortins: alpha MSH and the ACTH4-9 analogue Org 2766

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Effects of ACTH on seizure susceptibility in the developing brain.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7,Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin recep

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

alpha-Melanocyte stimulating hormone: immunohistochemical identification and mapping in neurons of rat brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Deletion of crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Behavioral effects of [4-norleucine, 7-D-phenylalanine]-alpha-melanocyte-stimulating hormone.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Molecular cloning of a mouse melanocortin 5 receptor gene widely expressed in peripheral tissues.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Design, synthesis, and biological activities of cyclic lactam peptide analogues of dynorphine A(1-11)-NH2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

The effect of adrenocorticotrophic hormone (ACTH) on avoidance conditioning in the adrenalectomized rat

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Relation of adrenocortical activity and adaptive behavior.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Nucleotide sequence of cloned cDNA for bovine corticotropin-β-lipotropin precursor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

B-50, the growth associated protein-43: modulation of cell morphology and communication in the nervous system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Conformation of the core sequence in melanocortin peptides directs selectivity for the melanocortin MC3 and MC4 receptors.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Dual agonistic and antagonistic property of nonpeptide angiotensin AT1 ligands: susceptibility to receptor mutations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Melanocortin receptors and delta-opioid receptor mediate opposite signalling actions of POMC-derived peptides in CATH.a cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

half-Cys4,half-Cys10-alpha-Melanocyte-stimulating hormone: a cyclic alpha-melanotropin exhibiting superagonist biological activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Characterisation of the melanocortin 4 receptor by radioligand binding

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Selectivity of cyclic [D-Nal7] and [D-Phe7] substituted MSH analogues for the melanocortin receptor subtypes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Discovery of novel melanocortin4receptor selective MSH analogues

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Mice lacking melanin-concentrating hormone are hypophagic and lean

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

The periaqueductal gray: a prerequisite for ACTH-induced excessive grooming

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Ethology and neurobiology of grooming behavior

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Attenuation of morphine tolerance and dependence by α-melanocyte stimulating hormone (α-MSH)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Melanotropin receptors in the brain are differentially distributed and recognize both corticotropin and alpha-melanocyte stimulating hormone.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Heterogeneity of brain melanocortin receptors suggested by differential ligand binding in situ.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Specific receptors for alpha-melanocyte-stimulating hormone are widely distributed in tissues of rodents

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Putative neurotrophic factors and functional recovery from peripheral nerve damage in the rat

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

The role of central melanocortin receptors in the activation of the hypothalamus-pituitary-adrenal-axis and the induction of excessive grooming

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Adrenocorticotropin in Rat Brain: Immunocytochemical Localization in Cells and Axons

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Differential behavioral effects of ACTH 4–10 and [D-Phe7]ACTH 4–10

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

ACTH-like neurotropic peptides: possible regulators of rat brain cyclic AMP

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Intracerebroventricular acth activates the pituitary-adrenal system:Dissociation from a behavioral response

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

Isolation and Characterization of the Bovine Corticotropin/β-Lipotropin Precursor Gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

inferred from DOI database lookup

7 January 2021

based on heuristic

A time-structured analysis of hypothalamically induced increases in self-grooming and activity in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900537-9

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0014-2999(00)00537-9

1 reference

30 July 2017

1 reference

PubMed ID

11033310