Cellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk. (Q34061825)

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15 January 2020

title

Cellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk (English)

1 reference

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15 January 2020

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8

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15 January 2020

7

F S Collins

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15 January 2020

author name string

M G Rees

1

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15 January 2020

S Wincovitch

2

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15 January 2020

J Schultz

3

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15 January 2020

R Waterstradt

4

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15 January 2020

N L Beer

5

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15 January 2020

S Baltrusch

6

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15 January 2020

publication date

25 October 2011

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15 January 2020

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15 January 2020

volume

55

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15 January 2020

issue

1

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15 January 2020

page(s)

114-122

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https://scigraph.springernature.com/pub.10.1007/s00125-011-2348-5

15 January 2020

exact match

0 references

cites work

Genomics, type 2 diabetes, and obesity

1 reference

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From genetic association to molecular mechanism

28 July 2018

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Quantitative image analysis reveals that phosphorylation of liver-type isozyme of fructose-6-phosphate 2-kinase/fructose-2,6-bisphosphatase does not affect nuclear translocation of glucokinase in rat primary hepatocytes

28 July 2018

1 reference

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Endogenous activation of glucokinase by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is glucose dependent

28 July 2018

1 reference

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Biological, clinical and population relevance of 95 loci for blood lipids

28 July 2018

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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

28 July 2018

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Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

28 July 2018

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Kinetics of transport and phosphorylation of glucose in cancer cells.

28 July 2018

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The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276843

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

28 July 2018

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Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276843

Interaction of glucokinase with the liver regulatory protein is conferred by leucine-asparagine motifs of the enzyme

28 July 2018

1 reference

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Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein

28 July 2018

1 reference

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Differences in regulatory properties between human and rat glucokinase regulatory protein

28 July 2018

1 reference

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Characterization of glucokinase regulatory protein-deficient mice

28 July 2018

1 reference

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Marking synaptic activity in dendritic spines with a calpain substrate exhibiting fluorescence resonance energy transfer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276843

Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276843

Mice mutant for glucokinase regulatory protein exhibit decreased liver glucokinase: a sequestration mechanism in metabolic regulation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276843

Nuclear location of the regulatory protein of glucokinase in rat liver and translocation of the regulator to the cytoplasm in response to high glucose

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276843

A protein from rat liver confers to glucokinase the property of being antagonistically regulated by fructose 6-phosphate and fructose 1-phosphate

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276843

Binding of sorbitol 6-phosphate and of fructose 1-phosphate to the regulatory protein of liver glucokinase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276843

Chapter 4 Preparation of Isolated Rat Liver Cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276843

Mutations in the glucokinase regulatory protein gene in 2p23 in obese French caucasians

28 July 2018

1 reference

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Activation and translocation of glucokinase in rat primary hepatocytes monitored by high content image analysis

21 January 2018

1 reference

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Effects of 34 risk loci for type 2 diabetes or hyperglycemia on lipoprotein subclasses and their composition in 6,580 nondiabetic Finnish men.

21 January 2018

1 reference

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Treatment of type 2 diabetes by adenoviral-mediated overexpression of the glucokinase regulatory protein

21 January 2018

1 reference

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Evidence for glucose and sorbitol-induced nuclear export of glucokinase regulatory protein in hepatocytes

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22038520

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Enhanced oxygen delivery reverses anaerobic metabolic states in prolonged sandwich rat hepatocyte culture

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22038520

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S00125-011-2348-5

1 reference

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Dimensions Publication ID

15 January 2020

0 references

1 reference

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15 January 2020

1 reference