From Genetic Association to Molecular Mechanism (Q37793985)

23 August 2017

title

From genetic association to molecular mechanism (English)

1 reference

23 August 2017

From Genetic Association to Molecular Mechanism (English)

1 reference

https://api.crossref.org/works/10.1007/S11892-010-0150-2

22 July 2024

Martijn van de Bunt

1

0 references

Anna Gloyn

object named as

Anna L Gloyn

2

0 references

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=20878272

22 July 2024

publication date

1 December 2010

1 reference

full work available at URL

23 August 2017

http://www.current-reports.com/1534-4827/10/452

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20878272

http://link.springer.com/content/pdf/10.1007/s11892-010-0150-2.pdf

22 July 2024

file format

Portable Document Format

1 reference

https://api.crossref.org/works/10.1007/S11892-010-0150-2

http://link.springer.com/article/10.1007/s11892-010-0150-2/fulltext.html

22 July 2024

1 reference

https://api.crossref.org/works/10.1007/S11892-010-0150-2

http://link.springer.com/content/pdf/10.1007/s11892-010-0150-2

22 July 2024

1 reference

https://api.crossref.org/works/10.1007/S11892-010-0150-2

22 July 2024

published in

Current diabetes report

1 reference

23 August 2017

volume

10

1 reference

23 August 2017

issue

6

1 reference

23 August 2017

page(s)

452-466

1 reference

Mutations in the glucokinase regulatory protein gene in 2p23 in obese French caucasians

23 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS11892-010-0150-2

Ase1/Prc1-dependent spindle elongation corrects merotely during anaphase in fission yeast

21 January 2018

1 reference

12 December 2020

A single-nucleotide polymorphism in a methylatable Foxa2 binding site of the G6PC2 promoter is associated with insulin secretion in vivo and increased promoter activity in vitro

1 reference

12 December 2020

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

1 reference

12 December 2020

Treatment of type 2 diabetes by adenoviral-mediated overexpression of the glucokinase regulatory protein

1 reference

12 December 2020

Prox1 activity controls pancreas morphogenesis and participates in the production of "secondary transition" pancreatic endocrine cells.

1 reference

12 December 2020

Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure

1 reference

12 December 2020

Conditional ablation of Notch signaling in pancreatic development

1 reference

12 December 2020

Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development

1 reference

12 December 2020

Voltage-gated ion channels in human pancreatic beta-cells: electrophysiological characterization and role in insulin secretion.

1 reference

12 December 2020

Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

1 reference

12 December 2020

Sequence variations in the human Kir6.2 gene, a subunit of the beta-cell ATP-sensitive K-channel: no association with NIDDM in while Caucasian subjects or evidence of abnormal function when expressed in vitro

1 reference

12 December 2020

p16INK4a induces an age-dependent decline in islet regenerative potential

1 reference

12 December 2020

Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function

1 reference

12 December 2020

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

1 reference

12 December 2020

Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

1 reference

12 December 2020

Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance

1 reference

12 December 2020

A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene

1 reference

12 December 2020

Developmental and species-divergent globin switching are driven by BCL11A

1 reference

12 December 2020

The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver

1 reference

12 December 2020

Characterization of the role of CaMKI-like kinase (CKLiK) in human granulocyte function

1 reference

12 December 2020

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

1 reference

12 December 2020

FTO effect on energy demand versus food intake

1 reference

12 December 2020

Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion

1 reference

12 December 2020

IGF2 mRNA-binding protein 2: biological function and putative role in type 2 diabetes

1 reference

12 December 2020

The development of several organs and appendages is impaired in mice lacking Sp6.

1 reference

12 December 2020

Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation

1 reference

12 December 2020

Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion.

1 reference

12 December 2020

Coexpression of the type 2 diabetes susceptibility gene variants KCNJ11 E23K and ABCC8 S1369A alter the ATP and sulfonylurea sensitivities of the ATP-sensitive K(+) channel

1 reference

12 December 2020

Mouse models created to study the pathophysiology of Type 2 diabetes

1 reference

12 December 2020

Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p.

1 reference

12 December 2020

Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene

1 reference

12 December 2020

K(IR)6.2 polymorphism predisposes to type 2 diabetes by inducing overactivity of pancreatic beta-cell ATP-sensitive K(+) channels

1 reference

12 December 2020

Survey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta-cell replication and function in vivo

1 reference

12 December 2020

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

1 reference

12 December 2020

hVH-5: a protein tyrosine phosphatase abundant in brain that inactivates mitogen-activated protein kinase

1 reference

12 December 2020

Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMI.

1 reference

12 December 2020

Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes

1 reference

12 December 2020

RETRACTED: Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets

1 reference

12 December 2020

The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes

1 reference

12 December 2020

Inactivation of the Fto gene protects from obesity

1 reference

12 December 2020

Differences in regulatory properties between human and rat glucokinase regulatory protein

1 reference

12 December 2020

Cloning and characterization of AWP1, a novel protein that associates with serine/threonine kinase PRK1 in vivo

1 reference

12 December 2020

Kir6.2 variant E23K increases ATP-sensitive K+ channel activity and is associated with impaired insulin release and enhanced insulin sensitivity in adults with normal glucose tolerance

1 reference

12 December 2020

TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta

1 reference

12 December 2020

Deletion of the gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen results in a mild metabolic phenotype.

1 reference

12 December 2020

ADAMTS9 is a cell-autonomously acting, anti-angiogenic metalloprotease expressed by microvascular endothelial cells

1 reference

12 December 2020

The Wnt signaling pathway in development and disease

1 reference

12 December 2020

1 reference

12 December 2020

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

1 reference

12 December 2020

Kir6.2 polymorphisms sensitize beta-cell ATP-sensitive potassium channels to activation by acyl CoAs: a possible cellular mechanism for increased susceptibility to type 2 diabetes?

1 reference

12 December 2020

A variant in CDKAL1 influences insulin response and risk of type 2 diabetes

1 reference

12 December 2020

Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia

1 reference

12 December 2020

Lack of pancreatic body and tail in HNF1B mutation carriers

1 reference

12 December 2020

Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus.

1 reference

12 December 2020

A common nonsynonymous single nucleotide polymorphism in the SLC30A8 gene determines ZnT8 autoantibody specificity in type 1 diabetes

1 reference

12 December 2020

Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2

1 reference

12 December 2020

Prevalence of loss-of-function FTO mutations in lean and obese individuals

1 reference

12 December 2020

Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis

1 reference

12 December 2020

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

1 reference

12 December 2020

The tetraspanin Tm4sf3 is localized to the ventral pancreas and regulates fusion of the dorsal and ventral pancreatic buds

1 reference

12 December 2020

Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies

1 reference

12 December 2020

Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas

1 reference

12 December 2020

Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels

1 reference

12 December 2020

Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice.

1 reference

12 December 2020

Characterization of glucokinase regulatory protein-deficient mice

1 reference

12 December 2020

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

1 reference

12 December 2020

Insulin signaling regulating genes: effect on T2DM and cardiovascular risk.

1 reference

12 December 2020

A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels

1 reference

12 December 2020

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

1 reference

12 December 2020

Enhanced islet expansion by beta-cell proliferation in young diabetes-prone rats fed a protective diet

1 reference

12 December 2020

A genome-wide association study identifies novel risk loci for type 2 diabetes

1 reference

12 December 2020

Update of mutations in the genes encoding the pancreatic beta-cell K(ATP) channel subunits Kir6.2 (KCNJ11) and sulfonylurea receptor 1 (ABCC8) in diabetes mellitus and hyperinsulinism

1 reference

12 December 2020

Common variants associated with breast cancer in genome-wide association studies are modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers

1 reference

12 December 2020

TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells

1 reference

12 December 2020

Finding the missing heritability of complex diseases

1 reference

12 December 2020

Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: identification of ANRIL, an antisense noncoding RNA whose expression coclusters with ARF.

1 reference

12 December 2020

Insights into the regulation of a common variant of HMGA2 associated with human height during embryonic development

1 reference

12 December 2020

Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants

1 reference

12 December 2020

Lack of TCF2/vHNF1 in mice leads to pancreas agenesis

1 reference

12 December 2020

The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

1 reference

12 December 2020

Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling

1 reference

12 December 2020

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

1 reference

12 December 2020

Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia.

1 reference

12 December 2020

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase

1 reference

12 December 2020

Genetic and functional assessment of the role of the rs13431652-A and rs573225-A alleles in the G6PC2 promoter that are strongly associated with elevated fasting glucose levels.

1 reference

12 December 2020

Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations

1 reference

12 December 2020

A genetic switch in pancreatic beta-cells: implications for differentiation and haploinsufficiency.

1 reference

12 December 2020

Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes.

1 reference

12 December 2020

Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells

1 reference

12 December 2020

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

1 reference

12 December 2020

Common variants in WFS1 confer risk of type 2 diabetes

1 reference

12 December 2020

Parental origin of sequence variants associated with complex diseases

1 reference

12 December 2020

Significant change in insulin production, glucose tolerance and ER stress signaling in transgenic mice coexpressing insulin-siRNA and human IDE

1 reference

12 December 2020

How to make beta cells?

1 reference

12 December 2020

A PH domain in the Arf GTPase-activating protein (GAP) ARAP1 binds phosphatidylinositol 3,4,5-trisphosphate and regulates Arf GAP activity independently of recruitment to the plasma membranes.

1 reference

12 December 2020

Identification of fructose 6-phosphate- and fructose 1-phosphate-binding residues in the regulatory protein of glucokinase

1 reference

12 December 2020

Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations

1 reference

12 December 2020

Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps

1 reference

12 December 2020

Unique arrangement of alpha- and beta-cells in human islets of Langerhans

1 reference

12 December 2020

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

1 reference

12 December 2020

Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region

1 reference

12 December 2020

Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans

21

1 reference

https://api.crossref.org/works/10.1007/S11892-010-0150-2

A map of open chromatin in human pancreatic islets

22 July 2024

41

1 reference

https://api.crossref.org/works/10.1007/S11892-010-0150-2

22 July 2024

Mouse chromosome 2

43

1 reference

https://api.crossref.org/works/10.1007/S11892-010-0150-2

Journal of Clinical Investigation

22 July 2024

59

118

2620

WM Chen

2008

1 reference

https://api.crossref.org/works/10.1007/S11892-010-0150-2

22 July 2024

Identifiers

1 reference

23 August 2017

1 reference