NMR resonance assignments of thrombin reveal the conformational and dynamic effects of ligation. (Q34069668)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20660315%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

title

NMR resonance assignments of thrombin reveal the conformational and dynamic effects of ligation (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20660315%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

author

Bernhard C Lechtenberg

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20660315%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

author name string

Daniel J D Johnson

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20660315%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Stefan M V Freund

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20660315%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

James A Huntington

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20660315%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

language of work or name

English

0 references

publication date

21 July 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20660315%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

number of pages

6

1 reference

Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20660315%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

volume

107

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20660315%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

page(s)

14087-14092

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20660315%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

issue

32

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20660315%20AND%20SRC:MED&resulttype=core&format=json

Molecular basis of thrombomodulin activation of slow thrombin

8 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922568

Slow thrombin is zymogen-like

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922568

How Na+ activates thrombin--a review of the functional and structural data

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922568

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922568

Cofactor-induced and mutational activity enhancement of coagulation factor VIIa

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922568

Expression of allosteric linkage between the sodium ion binding site and exosite I of thrombin during prothrombin activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922568

Thrombin-cofactor interactions: structural insights into regulatory mechanisms

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922568

Crystal structure of wild-type human thrombin in the Na+-free state.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922568

Molecular recognition mechanisms of thrombin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922568

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922568

Allosteric changes in solvent accessibility observed in thrombin upon active site occupation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922568

Crystal structure of the complex between thrombin and the central "E" region of fibrin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922568

Thrombomodulin allosterically modulates the activity of the anticoagulant thrombin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922568

WATERFALL SEQUENCE FOR INTRINSIC BLOOD CLOTTING.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922568

AN ENZYME CASCADE IN THE BLOOD CLOTTING MECHANISM, AND ITS FUNCTION AS A BIOCHEMICAL AMPLIFIER.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922568

Solvent accessibility of the thrombin-thrombomodulin interface

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922568

Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922568

NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922568

The molecular environment of the Na+ binding site of thrombin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922568

On the size of the active site in proteases. I. Papain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922568

Allosteric changes in thrombin's activity produced by peptides corresponding to segments of natural inhibitors and substrates

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922568

Thrombin is a Na(+)-activated enzyme

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922568

Thrombomodulin tightens the thrombin active site loops to promote protein C activation

5 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1005255107

High-level bacterial expression and 15N-alanine-labeling of bovine trypsin. Application to the study of trypsin-inhibitor complexes and trypsinogen activation by NMR spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1005255107

Mechanism of Na(+) binding to thrombin resolved by ultra-rapid kinetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1005255107

Sequence-specific NMR assignment of proteins by global fragment mapping with the program MAPPER.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1005255107

21 January 2018

The Protein C Pathway

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1005255107

TROSY-type Triple-Resonance Experiments for Sequential NMR Assignments of Large Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1005255107

The fifth and sixth growth factor-like domains of thrombomodulin bind to the anion-binding exosite of thrombin and alter its specificity

21 January 2018

1 reference

12 December 2020

Molecular recognition by thrombin. Role of the slow-->fast transition, site-specific ion binding energetics and thermodynamic mapping of structural components

1 reference

12 December 2020

Large heat capacity change in a protein-monovalent cation interaction

1 reference

12 December 2020

Kinetic pathway for the slow to fast transition of thrombin. Evidence of linked ligand binding at structurally distinct domains

1 reference

12 December 2020

Thrombomodulin increases the rate of thrombin inhibition by BPTI

1 reference

12 December 2020

Electrostatic steering and ionic tethering in the formation of thrombin-hirudin complexes: the role of the thrombin anion-binding exosite-I

1 reference

12 December 2020

The active site of thrombin is altered upon binding to thrombomodulin. Two distinct structural changes are detected by fluorescence, but only one correlates with protein C activation

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1005255107

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20660315%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20660315%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference