Linker mutations reveal the complexity of synaptotagmin 1 action during synaptic transmission (Q34069969)

24657966

30 July 2017

title

Linker mutations reveal the complexity of synaptotagmin 1 action during synaptic transmission (English)

1 reference

30 July 2017

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24657966%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Edwin Chapman

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24657966%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

author name string

Huisheng Liu

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24657966%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Renhao Xue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24657966%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Hirohide Takahashi

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24657966%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

J Michael Edwardson

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24657966%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

language of work or name

English

0 references

publication date

23 March 2014

1 reference

30 July 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24657966%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

volume

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24657966%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

issue

5

1 reference

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11 June 2020

page(s)

670-677

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24657966%20AND%20SRC:MED&resulttype=core&format=json

Glycosylation is dispensable for sorting of synaptotagmin 1 but is critical for targeting of SV2 and synaptophysin to recycling synaptic vesicles

11 June 2020

cites work

1 reference

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Axonal and dendritic synaptotagmin isoforms revealed by a pHluorin-syt functional screen

5 July 2018

1 reference

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Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release.

5 July 2018

1 reference

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Receptor binding enables botulinum neurotoxin B to sense low pH for translocation channel assembly.

5 July 2018

1 reference

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Mechanism and function of synaptotagmin-mediated membrane apposition

5 July 2018

1 reference

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Spontaneous glutamate release is independent of calcium influx and tonically activated by the calcium-sensing receptor

5 July 2018

1 reference

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Spontaneous neurotransmission: an independent pathway for neuronal signaling?

5 July 2018

1 reference

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Membrane penetration by synaptotagmin is required for coupling calcium binding to vesicle fusion in vivo

5 July 2018

1 reference

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Regulation of exocytosis and fusion pores by synaptotagmin-effector interactions

5 July 2018

1 reference

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Single-molecule FRET-derived model of the synaptotagmin 1-SNARE fusion complex

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139111

Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139111

The Pfam protein families database

5 July 2018

1 reference

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Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139111

Synaptotagmin-mediated bending of the target membrane is a critical step in Ca(2+)-regulated fusion

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139111

Autapses and networks of hippocampal neurons exhibit distinct synaptic transmission phenotypes in the absence of synaptotagmin I.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139111

Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139111

Conformation and membrane position of the region linking the two C2 domains in synaptotagmin 1 by site-directed spin labeling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139111

Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139111

Analysis of the synaptotagmin family during reconstituted membrane fusion. Uncovering a class of inhibitory isoforms

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139111

How does synaptotagmin trigger neurotransmitter release?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139111

Probing polyproline structure and dynamics by photoinduced electron transfer provides evidence for deviations from a regular polyproline type II helix.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139111

Structure of human synaptotagmin 1 C2AB in the absence of Ca2+ reveals a novel domain association

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139111

How synaptotagmin promotes membrane fusion.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139111

Ca2+-triggered simultaneous membrane penetration of the tandem C2-domains of synaptotagmin I

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139111

Ca(2+)-synaptotagmin directly regulates t-SNARE function during reconstituted membrane fusion.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139111

Synaptotagmin isoforms couple distinct ranges of Ca2+, Ba2+, and Sr2+ concentration to SNARE-mediated membrane fusion

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139111

Synaptic mechanisms of persistent reverberatory activity in neuronal networks

5 July 2018

1 reference

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Synaptotagmin gene content of the sequenced genomes

5 July 2018

1 reference

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Dysferlin and the plasma membrane repair in muscular dystrophy

5 July 2018

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Synaptotagmin I, a Ca2+ sensor for neurotransmitter release

5 July 2018

1 reference

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Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis

5 July 2018

1 reference

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Role of synaptotagmin in Ca2+-triggered exocytosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139111

C2A activates a cryptic Ca(2+)-triggered membrane penetration activity within the C2B domain of synaptotagmin I.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139111

Three-dimensional structure of the synaptotagmin 1 C2B-domain: synaptotagmin 1 as a phospholipid binding machine

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139111

Intracellular calcium dependence of large dense-core vesicle exocytosis in the absence of synaptotagmin I

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139111

The C2B domain of synaptotagmin is a Ca(2+)-sensing module essential for exocytosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139111

Crystal structure of the cytosolic C2A-C2B domains of synaptotagmin III. Implications for Ca(+2)-independent snare complex interaction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139111

Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139111

Ca2+ binding to synaptotagmin: how many Ca2+ ions bind to the tip of a C2-domain?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139111

SNAREpins: minimal machinery for membrane fusion

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139111

Identification of a novel protein containing two C2 domains selectively expressed in the rat brain and kidney.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139111

SNAP receptors implicated in vesicle targeting and fusion

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139111

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139111

Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139111

Inhibitory transmission mediated by asynchronous transmitter release

5 July 2018

1 reference

Integration of asynchronously released quanta prolongs the postsynaptic spike window

21 January 2018

1 reference

Miniature neurotransmission stabilizes synaptic function via tonic suppression of local dendritic protein synthesis.

21 January 2018

1 reference

Direct interaction of a Ca2+-binding loop of synaptotagmin with lipid bilayers

21 January 2018

1 reference

PIP2 increases the speed of response of synaptotagmin and steers its membrane-penetration activity toward the plasma membrane.

21 January 2018

1 reference

Synaptotagmin increases the dynamic range of synapses by driving Ca²+-evoked release and by clamping a near-linear remaining Ca²+ sensor

21 January 2018

1 reference

Synaptotagmin C2B domain regulates Ca2+-triggered fusion in vitro: critical residues revealed by scanning alanine mutagenesis

21 January 2018

1 reference

Reconstitution of Ca2+-regulated membrane fusion by synaptotagmin and SNAREs.

21 January 2018

1 reference

Fusion pore dynamics are regulated by synaptotagmin*t-SNARE interactions.

21 January 2018

1 reference

Synaptotagmin-1, -2, and -9: Ca(2+) sensors for fast release that specify distinct presynaptic properties in subsets of neurons

21 January 2018

1 reference

The protein coat in membrane fusion: lessons from fission

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24657966

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipids

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24657966

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NN.3681

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24657966%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

11 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24657966%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

24657966

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24657966%20AND%20SRC:MED&resulttype=core&format=json