Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL. (Q34069986)

30 July 2017

title

Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL. (English)

1 reference

30 July 2017

Roland Eils

4

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author name string

Nicolai Fricker

1

1 reference

30 July 2017

Joel Beaudouin

2

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30 July 2017

Petra Richter

3

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30 July 2017

Peter H Krammer

5

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30 July 2017

Inna N Lavrik

6

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30 July 2017

language of work or name

English

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publication date

1 August 2010

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30 July 2017

number of pages

13

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based on heuristic

inferred from page(s)

published in

Journal of Cell Biology

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30 July 2017

volume

190

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30 July 2017

issue

3

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30 July 2017

page(s)

377-389

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describes a project that uses

30 July 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2922645/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Dynamics within the CD95 death-inducing signaling complex decide life and death of cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922645

Understanding apoptosis by systems biology approaches

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922645

A new C-terminal cleavage product of procaspase-8, p30, defines an alternative pathway of procaspase-8 activation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922645

Mechanism of procaspase-8 activation by c-FLIPL

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922645

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922645

PKC-mediated phosphorylation regulates c-FLIP ubiquitylation and stability

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922645

FLIP and the death effector domain family

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922645

Quantitative analysis of pathways controlling extrinsic apoptosis in single cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922645

Mutational analyses of c-FLIPR, the only murine short FLIP isoform, reveal requirements for DISC recruitment

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922645

Analysis of CD95 threshold signaling: triggering of CD95 (FAS/APO-1) at low concentrations primarily results in survival signaling

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922645

Mathematical modeling identifies inhibitors of apoptosis as mediators of positive feedback and bistability

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922645

Systems analysis of effector caspase activation and its control by X-linked inhibitor of apoptosis protein

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922645

cFLIP regulation of lymphocyte activation and development

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922645

Caspases: pharmacological manipulation of cell death

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922645

Selective knockdown of the long variant of cellular FLICE inhibitory protein augments death receptor-mediated caspase-8 activation and apoptosis.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922645

28 July 2018

Death receptor signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922645

Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922645

N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922645

Interdimer processing mechanism of procaspase-8 activation.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922645

The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922645

Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922645

c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922645

Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922645

The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922645

Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922645

The role of c-FLIP in modulation of CD95-induced apoptosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922645

An induced proximity model for caspase-8 activation.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922645

FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922645

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922645

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922645

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922645

Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922645

Monoclonal antibody-mediated tumor regression by induction of apoptosis.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922645

Modeling a snap-action, variable-delay switch controlling extrinsic cell death

28 July 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201002060

Cellular FLIP (long form) regulates CD8+ T cell activation through caspase-8-dependent NF-kappa B activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201002060

Bistability analyses of a caspase activation model for receptor-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201002060

The protein structures that shape caspase activity, specificity, activation and inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201002060

c-FLIPR, a new regulator of death receptor-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201002060

The c-FLIP-NH2 terminus (p22-FLIP) induces NF-kappaB activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201002060

Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201002060

Mutation of a self-processing site in caspase-8 compromises its apoptotic but not its nonapoptotic functions in bacterial artificial chromosome-transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201002060

Life and death in peripheral T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201002060

Dynamics of outer mitochondrial membrane permeabilization during apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201002060

Systems Biology Toolbox for MATLAB: a computational platform for research in systems biology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201002060

The CD95 Receptor: Apoptosis Revisited

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20696707

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1083/JCB.201002060

1 reference

30 July 2017

1 reference

30 July 2017

1 reference