Blood cytokines as biomarkers of in vivo toxicity in preclinical safety assessment: considerations for their use. (Q34071983)

30 July 2017

5 references

19 June 2019

19 September 2019

20 November 2019

12 September 2020

19 November 2020

Blood cytokines as biomarkers of in vivo toxicity in preclinical safety assessment: considerations for their use. (English)

1 reference

biomedical investigative technique

30 July 2017

1 reference

19 November 2020

1 reference

19 September 2019

1 reference

20 November 2019

1 reference

12 September 2020

0 references

Jacqueline M Tarrant

1

1 reference

30 July 2017

6 May 2010

1 reference

PubMed ID

20447938

30 July 2017

1 September 2010

5 references

19 June 2019

19 September 2019

20 November 2019

12 September 2020

19 November 2020

Toxicological Sciences

6 references

30 July 2017

19 June 2019

19 September 2019

20 November 2019

12 September 2020

19 November 2020

117

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30 July 2017

1

1 reference

30 July 2017

4-16

1 reference

Creative Commons Attribution-NonCommercial

30 July 2017

5 references

19 June 2019

19 September 2019

20 November 2019

12 September 2020

19 November 2020

A circadian clock in macrophages controls inflammatory immune responses.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

Transcriptional control of the inflammatory response

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

Analytical validation of a highly sensitive microparticle-based immunoassay for the quantitation of IL-13 in human serum using the Erenna immunoassay system

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

Measurement and quality control issues in multiplex protein assays: a case study

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

Integration of cytokine and heterologous receptor signaling pathways

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

Chemokines and chemokine receptors: an overview.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

Characterization and potential clinical applications of autoantibodies against cytokines

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

Safety assessment and dose selection for first-in-human clinical trials with immunomodulatory monoclonal antibodies

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

Method validation of protein biomarkers in support of drug development or clinical diagnosis/prognosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

Cytokine and cytokine receptor gene polymorphisms and their functionality.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

A comparison of multiplex suspension array large-panel kits for profiling cytokines and chemokines in rheumatoid arthritis patients

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

Origin and physiological roles of inflammation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

A CD28 superagonistic antibody elicits 2 functionally distinct waves of T cell activation in rats

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

Post-transcriptional control of cytokine production

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

Strategic paths for biomarker qualification

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

The FDA critical path initiative and its influence on new drug development.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

Simultaneous detection of eight analytes in human serum by two commercially available platforms for multiplex cytokine analysis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

Primate TNF promoters reveal markers of phylogeny and evolution of innate immunity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

Toxicity as a result of immunostimulation by biologics

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

TGF-beta and atherosclerosis in man.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

The tumor necrosis factor alpha -308 G/A polymorphism does not influence inflammation and coagulation response in human endotoxemia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

Cytokines as potential biomarkers of liver toxicity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

Clinical and biological effects of recombinant human interleukin-18 administered by intravenous infusion to patients with advanced cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

Cytokines and toxicity in acetaminophen overdose

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

Method validation and measurement of biomarkers in nonclinical and clinical samples in drug development: a conference report.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

Drug-induced vascular injury--a quest for biomarkers.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

Forecasting the cytokine storm following systemic interleukin (IL)-2 administration

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

Of mice and not men: differences between mouse and human immunology

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

Multiplexed microsphere-based flow cytometric assays

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

Cytokines and related receptor-mediated signaling pathways

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

Platelet chemokines and their receptors: what is their relevance to platelet storage and transfusion practice?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

Inflammatory Cytokines in Nonpathological States

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

Biomarkers and surrogate endpoints: preferred definitions and conceptual framework

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

The pathophysiologic roles of interleukin-6 in human disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

Early response to bleomycin is characterized by different cytokine and cytokine receptor profiles in lungs.

5 July 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ134

Validation and comparison of two multiplex technologies, Luminex and Mesoscale Discovery, for human cytokine profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ134

Relationship between clinical parameters and cytokine profiles in inflamed gingival tissue and serum samples from patients with chronic periodontitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ134

Isolation of novel GRO genes and a phylogenetic analysis of the CXC chemokine subfamily in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ134

Summary of a workshop on nonclinical and clinical immunotoxicity assessment of immunomodulatory drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ134

Reproducibility and correlations of multiplex cytokine levels in asymptomatic persons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ134

Stability and reproducibility of simultaneously detected plasma and serum cytokine levels in asymptomatic subjects

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

Stability of interleukin 6, soluble interleukin 6 receptor, interleukin 10 and CC16 in human serum.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923281

Solid-phase and bead-based cytokine immunoassay: a comparison

28 October 2018

1 reference

12 December 2020

Effects of single-dose interleukin-12 exposure on interleukin-12-associated toxicity and interferon-gamma production

1 reference

12 December 2020

Down-regulation of the pharmacokinetic-pharmacodynamic response to interleukin-12 during long-term administration to patients with renal cell carcinoma and evaluation of the mechanism of this “adaptive response” in mice

1 reference

12 December 2020

Characterization of the inflammatory response to a highly selective PDE4 inhibitor in the rat and the identification of biomarkers that correlate with toxicity

1 reference

12 December 2020

Evidence for degradation of cytokines in the serum of patients with atopic dermatitis by calcium-dependent protease

1 reference

12 December 2020

Variations in peripheral blood levels of immunoreactive tumor necrosis factor alpha (TNFalpha) throughout the menstrual cycle and secretion of TNFalpha from the human corpus luteum

1 reference

12 December 2020

Biomarkers in peripheral blood associated with vascular injury in Sprague-Dawley rats treated with the phosphodiesterase IV inhibitors SCH 351591 or SCH 534385

1 reference

12 December 2020

No association between tumor necrosis factor-alpha production and gene polymorphisms among inbred rat strains

1 reference

12 December 2020

Development, validation, and implementation of a multiplex immunoassay for the simultaneous determination of five cytokines in human serum

1 reference

12 December 2020

Induction of early inflammatory gene expression in a murine model of nonresuscitated, fixed-volume hemorrhage

1 reference

12 December 2020

Anti-cytokine autoantibodies are ubiquitous in healthy individuals

1 reference

12 December 2020

Multiplex bead array assays for detection of soluble cytokines: comparisons of sensitivity and quantitative values among kits from multiple manufacturers

1 reference

12 December 2020

Identifiers

DOI

10.1093/TOXSCI/KFQ134

1 reference

30 July 2017

1 reference

30 July 2017

1 reference

PubMed ID

20447938