Protein denaturation and protein:drugs interactions from intrinsic protein fluorescence measurements at the nanolitre scale (Q34072745)

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5 February 2020

title

Protein denaturation and protein:drugs interactions from intrinsic protein fluorescence measurements at the nanolitre scale (English)

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5 February 2020

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5

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5 February 2020

Paul A Dalby

7

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5 February 2020

6

Gabriel Aeppli

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5 February 2020

3

Sophie E Jackson

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5 February 2020

author name string

Matthieu Gaudet

1

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5 February 2020

Nina Remtulla

2

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5 February 2020

Ewan R G Main

4

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5 February 2020

publication date

1 August 2010

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5 February 2020

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5 February 2020

volume

19

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5 February 2020

issue

8

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5 February 2020

page(s)

1544-1554

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Direct observation of ultrafast folding and denatured state dynamics in single protein molecules

5 February 2020

cites work

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5 July 2018

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Mammalian target of rapamycin: a new target in prostate cancer

5 July 2018

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Micro- and nanofluidic systems for high-throughput biological screening

5 July 2018

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Evidence of an intermediate and parallel pathways in protein unfolding from single-molecule fluorescence.

5 July 2018

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Immunosuppression and tumor development in organ transplant recipients: the emerging dualistic role of rapamycin

5 July 2018

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Measurements of label free protein concentration and conformational changes using a microfluidic UV-LED method

5 July 2018

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Worldwide emergence of extensively drug-resistant tuberculosis

5 July 2018

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Protein hydrophobic collapse and early folding steps observed in a microfluidic mixer

5 July 2018

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Mapping protein collapse with single-molecule fluorescence and kinetic synchrotron radiation circular dichroism spectroscopy

5 July 2018

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Do protein molecules unfold in a simple shear flow?

5 July 2018

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Characterization of the FKBP.rapamycin.FRB ternary complex

5 July 2018

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Thermodynamic stability of carbonic anhydrase: measurements of binding affinity and stoichiometry using ThermoFluor.

5 July 2018

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Deep UV laser-induced fluorescence detection of unlabeled drugs and proteins in microchip electrophoresis

5 July 2018

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Femtomole mixer for microsecond kinetic studies of protein folding

5 July 2018

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Optimising enzyme function by directed evolution.

5 July 2018

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High-precision, high-throughput stability determinations facilitated by robotics and a semiautomated titrating fluorometer.

5 July 2018

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Hit and lead generation: beyond high-throughput screening

5 July 2018

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Combinatorial compound libraries for drug discovery: an ongoing challenge

5 July 2018

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A new microvolume technique for bioaffinity assays using two-photon excitation.

5 July 2018

1 reference

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Equilibrium denaturation of recombinant human FK binding protein in urea

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923507

Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin

5 July 2018

1 reference

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Substrate stabilization of lysozyme to thermal and guanidine hydrochloride denaturation.

5 July 2018

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Determination and analysis of urea and guanidine hydrochloride denaturation curves

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923507

Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin

5 July 2018

1 reference

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Folding of chymotrypsin inhibitor 2. 1. Evidence for a two-state transition

5 July 2018

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Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

5 July 2018

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Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex

5 July 2018

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Solution Structure of FKBP, a Rotamase Enzyme and Receptor for FK506 and Rapamycin

5 July 2018

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Correlation between dynamics and high affinity binding in an SH2 domain interaction

5 July 2018

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Crossref

https://api.crossref.org/works/10.1002%2FPRO.433

Rapid optimization of protein freeze-drying formulations using ultra scale-down and factorial design of experiment in microplates.

21 January 2018

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Analysis of protein-protein interactions by using droplet-based microfluidics.

28 October 2018

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Nanomechanical detection of antibiotic-mucopeptide binding in a model for superbug drug resistance

28 October 2018

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A microplate-based evaluation of complex denaturation pathways: structural stability of Escherichia coli transketolase.

28 October 2018

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Label-free detection of protein interactions using deep UV fluorescence lifetime microscopy.

28 October 2018

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Kinetic measurements of protein conformation in a microchip.

28 October 2018

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Determination of excitatory amino acids in biological fluids by capillary electrophoresis with optical fiber light-emitting diode induced fluorescence detection

28 October 2018

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High-throughput measurement of protein stability in microtiter plates

28 October 2018

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Structure-function relationships in the FK506-binding protein (FKBP) family of peptidylprolyl cis-trans isomerases

28 October 2018

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12 December 2020

H/D exchange- and mass spectrometry-based strategy for the thermodynamic analysis of protein-ligand binding

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12 December 2020

Capillary electrophoresis for the analysis of biopolymers

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12 December 2020

Does trifluoroethanol affect folding pathways and can it be used as a probe of structure in transition states?

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12 December 2020

Proteomics: delivering new routes to drug discovery - Part 2

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12 December 2020

Proteomics: delivering new routes to drug discovery - Part 1

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12 December 2020

Context-dependent nature of destabilizing mutations on the stability of FKBP12

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12 December 2020

Folding pathway of FKBP12 and characterisation of the transition state

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12 December 2020

The use of double mutants to detect structural changes in the active site of the tyrosyl-tRNA synthetase (Bacillus stearothermophilus)

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12 December 2020

Identifiers

DOI

10.1002/PRO.433

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20552687%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference

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5 February 2020

PubMed publication ID

20552687

1 reference