Allosterically controllable maxizymes cleave mRNA with high efficiency and specificity (Q34073726)

30 July 2017

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title

Allosterically controllable maxizymes cleave mRNA with high efficiency and specificity (English)

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30 July 2017

Kuwabara T

1

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30 July 2017

Warashina M

series ordinal

2

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30 July 2017

Taira K

series ordinal

3

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30 July 2017

publication date

1 November 2000

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30 July 2017

published in

Trends in Biotechnology

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30 July 2017

volume

18

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30 July 2017

issue

11

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30 July 2017

page(s)

462-468

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The hammerhead RNA domain, a model ribozyme

30 July 2017

cites work

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A general two-metal-ion mechanism for catalytic RNA

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Explanation by the double-metal-ion mechanism of catalysis for the differential metal ion effects on the cleavage rates of 5'-oxy and 5'-thio substrates by a hammerhead ribozyme

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A two-metal ion mechanism operates in the hammerhead ribozyme-mediated cleavage of an RNA substrate

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The hammerhead, hairpin and VS ribozymes are catalytically proficient in monovalent cations alone

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7 January 2021

The Hydrolysis of RNA: From Theoretical Calculations to the Hammerhead Ribozyme-Mediated Cleavage of RNA

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A further investigation and reappraisal of the thio effect in the cleavage reaction catalyzed by a hammerhead ribozyme

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A ribozyme with DNA in the hybridising arms displays enhanced cleavage ability

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7 January 2021

Chimeric DNA-RNA hammerhead ribozymes have enhanced in vitro catalytic efficiency and increased stability in vivo

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Enhancement of the cleavage rates of DNA-armed hammerhead ribozymes by various divalent metal ions

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Nuclease-resistant chimeric ribozymes containing deoxyribonucleotides and phosphorothioate linkages

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Minimal sequence requirements for ribozyme activity.

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Hammerhead ribozymes: importance of stem-loop II for activity

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Formation of a catalytically active dimer by tRNA(Val)-driven short ribozymes

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Characterization of several kinds of dimer minizyme: simultaneous cleavage at two sites in HIV-1 tat mRNA by dimer minizymes

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tRNAVal-heterodimeric maxizymes with high potential as geneinactivating agents: simultaneous cleavage at two sites in HIV-1 Tat mRNA in cultured cells

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7 January 2021

CTAB-mediated enrichment for active forms of novel dimeric maxizymes

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7 January 2021

Construction of a series of several self-cleaving RNA duplexes using synthetic 21-mers

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7 January 2021

Mutagenesis analysis of a self-cleaving RNA.

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7 January 2021

Sequence requirements of the hammerhead RNA self-cleavage reaction

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7 January 2021

Extended target-site specificity for a hammerhead ribozyme

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7 January 2021

Generality of the NUX rule: kinetic analysis of the results of systematic mutations in the trinucleotide at the cleavage site of hammerhead ribozymes

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7 January 2021

Comparative analysis of cleavage rates after systematic permutation of the NUX consensus target motif for hammerhead ribozymes

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7 January 2021

Sequence specificity of the hammerhead ribozyme revisited; the NHH rule

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7 January 2021

Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining

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7 January 2021

Translocation of c-abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia

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7 January 2021

Localization of the c-abl oncogene adjacent to a translocation break point in chronic myelocytic leukaemia

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7 January 2021

Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

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7 January 2021

Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene

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7 January 2021

An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity.

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7 January 2021

Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome

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Initiation of deregulated growth of multipotent progenitor cells by bcr-abl in vitro

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7 January 2021

A novel allosterically trans-activated ribozyme, the maxizyme, with exceptional specificity in vitro and in vivo

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7 January 2021

Comparison of the specificities and catalytic activities of hammerhead ribozymes and DNA enzymes with respect to the cleavage of BCR-ABL chimeric L6 (b2a2) mRNA

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7 January 2021

Tethering ribozymes to a retroviral packaging signal for destruction of viral RNA.

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7 January 2021

Expression of small, therapeutic RNAs in human cell nuclei.

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7 January 2021

Efficient ex vivo inhibition of perforin and Fas ligand expression by chimeric tRNA-hammerhead ribozymes

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7 January 2021

Factors governing the activity in vivo of ribozymes transcribed by RNA polymerase III.

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7 January 2021

RNA enzymes (ribozymes) as antiviral therapeutic agents

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7 January 2021

Ribozymes as potential anti-HIV-1 therapeutic agents.

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7 January 2021

Controlled, targeted, intracellular expression of ribozymes: progress and problems

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7 January 2021

Oncogene inactivation in a mouse model

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7 January 2021

Maxizymes, novel allosterically controllable ribozymes, can be designed to cleave various substrates

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7 January 2021

Nucleic acid molecular switches

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7 January 2021

Training ribozymes to switch

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7 January 2021

Specificity of novel allosterically trans- and cis-activated connected maxizymes that are designed to suppress BCR-ABL expression

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7 January 2021

Chemical and enzymatic probing of effector-mediated changes in the conformation of a maxizyme

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7 January 2021

10.1016/S0167-7799(00)01498-0

Identifiers

DOI

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30 July 2017

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