The epigenetic modifier PRDM5 functions as a tumor suppressor through modulating WNT/β-catenin signaling and is frequently silenced in multiple tumors. (Q34075626)

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English	The epigenetic modifier PRDM5 functions as a tumor suppressor through modulating WNT/β-catenin signaling and is frequently silenced in multiple tumors.	scientific article

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16 January 2020

The epigenetic modifier PRDM5 functions as a tumor suppressor through modulating WNT/β-catenin signaling and is frequently silenced in multiple tumors (English)

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16 January 2020

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16 January 2020

Anthony Tak-Cheung Chan

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Sai Wah Tsao

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Fan Fong Poon

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Gopesh Srivastava

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Gopesh Srivastava

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Xing-sheng Shu

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16 January 2020

Hua Geng

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16 January 2020

Jianming Ying

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16 January 2020

Chunhong Ma

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16 January 2020

Yajun Wang

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16 January 2020

Ying Ying

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16 January 2020

Jun Yu

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16 January 2020

Shi Huang

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16 January 2020

Xian Wang

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8 November 2011

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16 January 2020

e27346

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16 January 2020

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8 November 2011

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0 references

Epigenetic disruption of the WNT/beta-catenin signaling pathway in human cancers.

1 reference

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5 July 2018

Nuclear cyclin D1: an oncogenic driver in human cancer

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5 July 2018

The tumor suppressor PRDM5 regulates Wnt signaling at early stages of zebrafish development

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5 July 2018

Promoter methylation of the Wnt/beta-catenin signaling antagonist Dkk-3 is associated with poor survival in gastric cancer

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5 July 2018

Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis

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5 July 2018

Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells

1 reference

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5 July 2018

OPCML is a broad tumor suppressor for multiple carcinomas and lymphomas with frequently epigenetic inactivation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210799

5 July 2018

DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications

1 reference

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5 July 2018

Epigenetic disruption of interferon-gamma response through silencing the tumor suppressor interferon regulatory factor 8 in nasopharyngeal, esophageal and multiple other carcinomas.

1 reference

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5 July 2018

Epigenetic inactivation of the canonical Wnt antagonist SRY-box containing gene 17 in colorectal cancer

1 reference

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5 July 2018

WNT5A exhibits tumor-suppressive activity through antagonizing the Wnt/beta-catenin signaling, and is frequently methylated in colorectal cancer.

1 reference

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GSK-3beta regulates cyclin D1 expression: a new target for chemotherapy

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5 July 2018

PRDM5 identified as a target of epigenetic silencing in colorectal and gastric cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210799

5 July 2018

Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210799

5 July 2018

Epigenetic regulation of protein-coding and microRNA genes by the Gfi1-interacting tumor suppressor PRDM5

1 reference

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5 July 2018

Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer

1 reference

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Silencing of bidirectional promoters by DNA methylation in tumorigenesis

1 reference

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Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer

1 reference

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Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210799

5 July 2018

Epigenetic silencing of AXIN2 in colorectal carcinoma with microsatellite instability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210799

5 July 2018

Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation

1 reference

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The candidate tumor suppressor gene BLU, located at the commonly deleted region 3p21.3, is an E2F-regulated, stress-responsive gene and inactivated by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma.

1 reference

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5 July 2018

PRDM5 is silenced in human cancers and has growth suppressive activities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210799

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Histone methyltransferases in tumor suppression

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Discovery of novel targets for aberrant methylation in pancreatic carcinoma using high-throughput microarrays.

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Hypermethylation in human cancers of the RIZ1 tumor suppressor gene, a member of a histone/protein methyltransferase superfamily

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The candidate tumor suppressor gene, RASSF1A, from human chromosome 3p21.3 is involved in kidney tumorigenesis

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Deletions of chromosome 4 occur early during the pathogenesis of colorectal carcinoma

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Transcriptional repression by blimp-1 (PRDI-BF1) involves recruitment of histone deacetylase

1 reference

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PFM1 (PRDM4), a new member of the PR-domain family, maps to a tumor suppressor locus on human chromosome 12q23-q24.1

1 reference

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12 December 2020

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10.1371/JOURNAL.PONE.0027346

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2011PLoSO...627346S

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