The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death (Q34076866)

30 July 2017

The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death (English)

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30 July 2017

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Sapolsky RM

1

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PubMed ID

11063972

30 July 2017

language of work or name

English

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publication date

1 October 2000

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30 July 2017

Biological Psychiatry

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30 July 2017

48

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30 July 2017

8

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30 July 2017

755-765

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The Bcl-2 protein family: arbiters of cell survival

30 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Postischemic administration of AK275, a calpain inhibitor, provides substantial protection against focal ischemic brain damage.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Excitotoxic degeneration is initiated at non-random sites in cultured rat cerebellar neurons

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Does stress damage the brain?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Hippocampal volume reduction in major depression.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Glucocorticoids increase extracellular [3H]D-aspartate overflow in hippocampal cultures during cyanide-induced ischemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Oxidative stress, glutamate, and neurodegenerative disorders

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Stress and cognition: are corticosteroids good or bad guys?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Corticosterone exacerbates kainate-induced alterations in hippocampal tau immunoreactivity and spectrin proteolysis in vivo.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Corticosterone enhances kainic acid-induced calcium elevation in cultured hippocampal neurons

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Corticosterone impairs hippocampal neuronal calcium regulation--possible mediating mechanisms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Neurogenesis in the adult human hippocampus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Mitochondria in neurodegeneration: acute ischemia and chronic neurodegenerative diseases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Adrenalectomy or metyrapone-pretreatment abolishes cerebral metabolic responses to the serotonin agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) in the hippocampus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid beta-peptide toxicity in hippocampal neurons

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Global ischemia induces downregulation of Glur2 mRNA and increases AMPA receptor-mediated Ca2+ influx in hippocampal CA1 neurons of gerbil

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Neurogenesis in the neocortex of adult primates

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Mitochondria and apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Essential role of adenosine, adenosine A1 receptors, and ATP-sensitive K+ channels in cerebral ischemic preconditioning

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Glucocorticoids inhibit glucose transport in cultured hippocampal neurons and glia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Effects of glucocorticoids and norepinephrine on the excitability in the hippocampus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Mineralocorticoid receptor-mediated changes in membrane properties of rat CA1 pyramidal neurons in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Local Cerebral Glucose Utilization Is Increased in Acutely Adrenalectomized Rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Hippocampal glucocorticoid receptor activation enhances voltage-dependent Ca2+ conductances: relevance to brain aging

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Adrenalectomy increases phosphoinositide hydrolysis induced by norepinephrine or excitatory amino acids in rat hippocampal slices

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Prolonged Ca2+-dependent afterhyperpolarizations in hippocampal neurons of aged rats.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Glucocorticoids accelerate ATP loss following metabolic insults in cultured hippocampal neurons.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Inhibition of proteolysis protects hippocampal neurons from ischemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Regulation of NMDA channel function by endogenous Ca(2+)-dependent phosphatase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Excitatory amino acids as a final common pathway for neurologic disorders.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Intracellular calcium levels and calcium fluxes in the CA1 region of the rat hippocampal slice during in vitro ischemia: relationship to electrophysiological cell damage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Excitatory amino acid release from astrocytes during energy failure by reversal of sodium-dependent uptake.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Adrenalectomy attenuates kainic acid-induced spectrin proteolysis and heat shock protein 70 induction in hippocampus and cortex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Release of adenosine by activation of NMDA receptors in the hippocampus.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Mitochondrial Ca2+ transport and the role of intramitochondrial Ca2+ in the regulation of energy metabolism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Stress and cognitive function.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Glucocorticoids may alter antioxidant enzyme capacity in the brain: kainic acid studies.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Stress preferentially increases extraneuronal levels of excitatory amino acids in the prefrontal cortex: comparison to hippocampus and basal ganglia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Glucocorticoids mediate the stress-induced extracellular accumulation of glutamate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Glucocorticoid Inhibition of Glucose Uptake by Peripheral Tissues: Old and New Evidence, Molecular Mechanisms, and Physiological Significance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

The GluR2 (GluR-B) hypothesis: Ca(2+)-permeable AMPA receptors in neurological disorders

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Calbindin D28K gene transfer via herpes simplex virus amplicon vector decreases hippocampal damage in vivo following neurotoxic insults

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Twenty-four hour urinary cortisol and catecholamine excretion in combat-related posttraumatic stress disorder

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Controversies surrounding glucocorticoid-mediated cell death in the hippocampus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Glutamate release in severe brain ischaemia is mainly by reversed uptake.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

The neurotoxicity of excitatory amino acids is produced by passive chloride influx.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Neuronal apoptosis in acute necrotic insults: why is this subject such a mess?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Why stress is bad for your brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Glucocorticoids, stress, and their adverse neurological effects: relevance to aging

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Gene therapy using viral vectors for acute neurologic insults

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Distinct influx pathways, not calcium load, determine neuronal vulnerability to calcium neurotoxicity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Glycyrrhetinic acid, an inhibitor of 11 beta-hydroxysteroid dehydrogenase, alters local cerebral glucose utilization in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Hippocampal atrophy in recurrent major depression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Glucocorticoids exacerbate kainic acid-induced extracellular accumulation of excitatory amino acids in the rat hippocampus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Physiological elevations of glucocorticoids potentiate glutamate accumulation in the hippocampus.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Stress exacerbates neuron loss and cytoskeletal pathology in the hippocampus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Evolving concepts about the role of acidosis in ischemic neuropathology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Corticosterone accelerates hypoxia- and cyanide-induced ATP loss in cultured hippocampal astrocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Towards an understanding of the role of glutamate in neurodegenerative disorders: energy metabolism and neuropathology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Glucocorticoids Inhibit Glucose Transport and Glutamate Uptake in Hippocampal Astrocytes: Implications for Glucocorticoid Neurotoxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Elevated baseline and postdexamethasone cortisol levels

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Neuroprotective effect of YM90K, a novel AMPA/kainate receptor antagonist, in focal cerebral ischemia in cats.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Low urinary cortisol excretion in patients with posttraumatic stress disorder.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Gene therapy with HSP72 is neuroprotective in rat models of stroke and epilepsy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

Status epilepticus may be caused by loss of adenosine anticonvulsant mechanisms.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2800%2900971-9

10.1016/S0006-3223(00)00971-9

7 January 2021

Identifiers

DOI

1 reference

30 July 2017

1 reference

PubMed ID

11063972