Deletion of p66Shc in mice increases the frequency of size-change mutations in the lacZ transgene (Q34078928)

30 July 2017

Deletion of p66Shc in mice increases the frequency of size-change mutations in the lacZ transgene (English)

1 reference

30 July 2017

6

Jan Vijg

1 reference

30 July 2017

Elena Beltrami

1

1 reference

30 July 2017

Antonella Ruggiero

2

1 reference

30 July 2017

Rita Busuttil

3

1 reference

30 July 2017

Enrica Migliaccio

4

1 reference

30 July 2017

Pier Giuseppe Pelicci

5

1 reference

30 July 2017

Marco Giorgio

7

1 reference

30 July 2017

10 January 2013

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30 July 2017

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30 July 2017

12

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30 July 2017

2

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30 July 2017

177-183

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Genetic inactivation of the p66 isoform of ShcA is neuroprotective in a murine model of multiple sclerosis.

30 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4141878

The redox stress hypothesis of aging

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4141878

p66Shc mediates high-glucose and angiotensin II-induced oxidative stress renal tubular injury via mitochondrial-dependent apoptotic pathway

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4141878

Targeting cyclophilin D and the mitochondrial permeability transition enhances beta-cell survival and prevents diabetes in Pdx1 deficiency

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4141878

Essential role of the redox-sensitive kinase p66shc in determining energetic and oxidative status and cell fate in neuronal preconditioning

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4141878

p66SHC-mediated mitochondrial dysfunction in renal proximal tubule cells during oxidative injury

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4141878

Apoptosis and oxidative stress-related diseases: the p66Shc connection

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4141878

p66Shc links alpha1-adrenergic receptors to a reactive oxygen species-dependent AKT-FOXO3A phosphorylation pathway in cardiomyocytes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4141878

Uncoupling protein-2 regulates lifespan in mice.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4141878

p66Shc-generated oxidative signal promotes fat accumulation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4141878

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4141878

Effect of Ames dwarfism and caloric restriction on spontaneous DNA mutation frequency in different mouse tissues

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4141878

Role of the life span determinant P66(shcA) in ethanol-induced liver damage.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4141878

Activation of the lifespan regulator p66Shc through reversible disulfide bond formation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4141878

Intra-organ variation in age-related mutation accumulation in the mouse

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4141878

Apoptosis and aging: role of p66Shc redox protein.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4141878

Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4141878

Organ-specific increase in mutation accumulation and apoptosis rate in CuZn-superoxide dismutase-deficient mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4141878

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4141878

DNA repair, genome stability, and aging

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4141878

Mitochondria, oxidants, and aging

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4141878

Aging and genome maintenance: lessons from the mouse?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4141878

Evolution of Shc functions from nematode to human

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4141878

The p66shc adaptor protein controls oxidative stress response and life span in mammals

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4141878

Plasmid-based transgenic mouse model for studying in vivo mutations

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4141878

The cardioprotective effects elicited by p66(Shc) ablation demonstrate the crucial role of mitochondrial ROS formation in ischemia/reperfusion injury

28 July 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12036

Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12036

Evaluation of a plasmid-based transgenic mouse model for detecting in vivo mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12036

The redox enzyme p66Shc contributes to diabetes and ischemia-induced delay in cutaneous wound healing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12036

Deletion of p66shc gene protects against age-related endothelial dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12036

The p66Shc knocked out mice are short lived under natural condition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12036

Genetic deletion of the p66Shc adaptor protein protects from angiotensin II-induced myocardial damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12036

p66(Shc) has a pivotal function in impaired liver regeneration in aged mice by a redox-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12036

Rac1 leads to phosphorylation-dependent increase in stability of the p66shc adaptor protein: role in Rac1-induced oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12036

Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12036

Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12036

Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12036

Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12036

The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12036

p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12036

Genetic ablation of cyclophilin D rescues mitochondrial defects and prevents muscle apoptosis in collagen VI myopathic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12036

Decreased superoxide production in macrophages of long-lived p66Shc knock-out mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12036

A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12036

Impact of genome instability on transcription regulation of aging and senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12036

p66ShcA modulates tissue response to hindlimb ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12036

Detection and characterization of eukaryotic enzymes that recognize oxidative DNA damage.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4141878

Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis

28 October 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12036

Diabetes Promotes Cardiac Stem Cell Aging and Heart Failure, Which Are Prevented by Deletion of the p66 shc Gene

21 January 2018

1 reference

12 December 2020

Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc

1 reference

12 December 2020

Telomerase deficiency promotes oxidative stress by reducing catalase activity

1 reference

12 December 2020

Mitochondrial redox signalling by p66Shc mediates ALS-like disease through Rac1 inactivation

1 reference

12 December 2020

Identifiers

DOI

10.1111/ACEL.12036

1 reference

30 July 2017

1 reference

30 July 2017

1 reference