Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways (Q34082438)

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English	Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways	scientific article

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scholarly article

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Europe PubMed Central

30 July 2017

Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways (English)

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Europe PubMed Central

30 July 2017

genome-wide association study

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based on heuristic

inferred from title

Fernando Rivadeneira

9

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Europe PubMed Central

30 July 2017

André Uitterlinden

10

object named as

André G Uitterlinden

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Erik B van den Akker

7

object named as

Erik B van den Akker

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Joris Deelen

1

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Marian Beekman

15

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Jeanine Houwing-Duistermaat

14

object named as

Jeanine J Houwing-Duistermaat

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Europe PubMed Central

30 July 2017

object named as

Jelle J Goeman

12

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13

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P Eline Slagboom

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Europe PubMed Central

30 July 2017

Rudi Westendorp

11

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Rudi G J Westendorp

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Europe PubMed Central

30 July 2017

Diana van Heemst

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object named as

Diana van Heemst

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Europe PubMed Central

30 July 2017

Anton J M de Craen

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object named as

Anton J M de Craen

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Europe PubMed Central

30 July 2017

Stefan Bohringer

6

object named as

Stefan Böhringer

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Europe PubMed Central

30 July 2017

5

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Peter E Thijssen

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Europe PubMed Central

30 July 2017

author name string

Hae-Won Uh

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30 July 2017

Ramin Monajemi

3

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Europe PubMed Central

30 July 2017

publication date

24 November 2011

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Europe PubMed Central

30 July 2017

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Europe PubMed Central

30 July 2017

35

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Europe PubMed Central

30 July 2017

235-249

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Europe PubMed Central

30 July 2017

1

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Europe PubMed Central

30 July 2017

copyright license

Creative Commons Attribution-NonCommercial 2.0 Generic

24 November 2011

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April 2022 Public Data File from Crossref

copyright status

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Gene set analysis of SNP data: benefits, challenges, and future directions

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Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited

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Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1.

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Analysing biological pathways in genome-wide association studies

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Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data

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5 July 2018

The association of telomere length and genetic variation in telomere biology genes

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Insights into colon cancer etiology via a regularized approach to gene set analysis of GWAS data

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Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology

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A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium

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5 July 2018

Common variants near TERC are associated with mean telomere length

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5 July 2018

Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians

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Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations.

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5 July 2018

Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity

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Association of FOXO3A variation with human longevity confirmed in German centenarians

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Asymptotic tests of association with multiple SNPs in linkage disequilibrium

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Sequence variants at the TERT-CLPTM1L locus associate with many cancer types

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Pot1b deletion and telomerase haploinsufficiency in mice initiate an ATR-dependent DNA damage response and elicit phenotypes resembling dyskeratosis congenita

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FOXO3A genotype is strongly associated with human longevity

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Pathway analysis of seven common diseases assessed by genome-wide association

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Engineered telomere degradation models dyskeratosis congenita

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Mutations in the telomerase component NHP2 cause the premature ageing syndrome dyskeratosis congenita

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A HapMap harvest of insights into the genetics of common disease

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Analysis of multiple SNPs in a candidate gene or region

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Telomere length and mortality: a study of leukocytes in elderly Danish twins

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PLINK: a tool set for whole-genome association and population-based linkage analyses

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Stressing the role of FoxO proteins in lifespan and disease

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Analyzing gene expression data in terms of gene sets: methodological issues

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5 July 2018

Chromosome 4q25, microsomal transfer protein gene, and human longevity: novel data and a meta-analysis of association studies

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Critical nodes in signalling pathways: insights into insulin action

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5 July 2018

Shelterin: the protein complex that shapes and safeguards human telomeres

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POT1 and TRF2 cooperate to maintain telomeric integrity

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Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body

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Extended longevity in mice lacking the insulin receptor in adipose tissue

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Telomerase in the human organism

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A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function

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Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein

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Association of the FOXO3A locus with extreme longevity in a southern Italian centenarian study.

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Long-lived Drosophila with overexpressed dFOXO in adult fat body

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Inheritance of human longevity in Iceland.

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Genetic influence on human lifespan and longevity.

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Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population-based study.

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Longevity studies in GenomEUtwin.

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A genome-wide association study of acenocoumarol maintenance dosage.

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Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study.

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The SNP ratio test: pathway analysis of genome-wide association datasets

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The genetics of exceptional human longevity

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No association between telomere length and survival among the elderly and oldest old

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based on heuristic

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Telomere length predicts survival independent of genetic influences

1 reference

https://pubmed.ncbi.nlm.nih.gov/22113349

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11357-011-9340-3

1 reference

Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

30 July 2017

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