Methylation-dependent silencing of the reduced folate carrier gene in inherently methotrexate-resistant human breast cancer cells (Q34087168)

30 July 2017

Methylation-dependent silencing of the reduced folate carrier gene in inherently methotrexate-resistant human breast cancer cells (English)

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30 July 2017

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J Worm

1

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30 July 2017

A F Kirkin

series ordinal

2

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30 July 2017

K N Dzhandzhugazyan

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3

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30 July 2017

P Guldberg

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4

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30 July 2017

language of work or name

English

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publication date

16 August 2001

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Journal of Biological Chemistry

30 July 2017

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30 July 2017

276

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30 July 2017

39990-40000

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30 July 2017

43

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The pharmacology and clinical use of methotrexate

30 July 2017

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Methotrexate transport and resistance.

21 January 2018

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Karnofsky memorial lecture. Ode to methotrexate

21 January 2018

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Intrinsic and acquired resistance to methotrexate in acute leukemia.

21 January 2018

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Carrier-mediated membrane transport of folates in mammalian cells

21 January 2018

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MRP3, an organic anion transporter able to transport anti-cancer drugs

21 January 2018

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A reduced folate carrier mutation produces substrate-dependent alterations in carrier mobility in murine leukemia cells and methotrexate resistance with conservation of growth in 5-formyltetrahydrofolate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103181200

A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103181200

Down-regulation of reduced folate carrier gene (RFC1) expression after exposure to methotrexate in ZR-75-1 breast cancer cells.

21 January 2018

1 reference

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Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cells

21 January 2018

1 reference

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Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103181200

Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line

21 January 2018

1 reference

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A single amino acid difference within the folate transporter encoded by the murine RFC-1 gene selectively alters its interaction with folate analogues. Implications for intrinsic antifolate resistance and directional orientation of the transporter w

21 January 2018

1 reference

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A mutated murine reduced folate carrier (RFC1) with increased affinity for folic acid, decreased affinity for methotrexate, and an obligatory anion requirement for transport function.

21 January 2018

1 reference

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Mutations in the reduced folate carrier gene which confer dominant resistance to 5,10-dideazatetrahydrofolate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103181200

Cellular folates prevent polyglutamation of 5, 10-dideazatetrahydrofolate. A novel mechanism of resistance to folate antimetabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103181200

Impaired membrane transport in methotrexate-resistant CCRF-CEM cells involves early translation termination and increased turnover of a mutant reduced folate carrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103181200

Clustering of mutations in the first transmembrane domain of the human reduced folate carrier in GW1843U89-resistant leukemia cells with impaired antifolate transport and augmented folate uptake.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103181200

Reduced folate carrier gene (RFC1) expression and anti-folate resistance in transfected and non-selected cell lines

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M103181200

Breast tumor cell lines from pleural effusions

21 January 2018

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Topological and functional analysis of the human reduced folate carrier by hemagglutinin epitope insertion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103181200

High sensitivity mapping of methylated cytosines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103181200

Acetylated histones are associated with FMR1 in normal but not fragile X-syndrome cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103181200

The human c-Kirsten ras gene is activated by a novel mutation in codon 13 in the breast carcinoma cell line MDA-MB231.

21 January 2018

1 reference

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A one-step DGGE scanning method for detection of mutations in the K-, N-, and H-ras oncogenes: mutations at codons 12, 13 and 61 are rare in B-cell non-Hodgkin's lymphoma.

21 January 2018

1 reference

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New colorimetric cytotoxicity assay for anticancer-drug screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103181200

Isolation and characterization of genomic sequences involved in the regulation of the human reduced folate carrier gene (RFC1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103181200

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103181200

CpG-rich islands and the function of DNA methylation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M103181200

Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103181200

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103181200

Synergistic effect of histone hyperacetylation and DNA demethylation in the reactivation of the FMR1 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103181200

Probenecid reverses multidrug resistance in multidrug resistance-associated protein-overexpressing HL60/AR and H69/AR cells but not in P-glycoprotein-overexpressing HL60/Tax and P388/ADR cells

21 January 2018

1 reference

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Potentiation of some anticancer agents by dipyridamole against drug-sensitive and drug-resistant cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103181200

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103181200

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103181200

Yeast HOS3 forms a novel trichostatin A-insensitive homodimer with intrinsic histone deacetylase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103181200

Evidence that silencing of the HPRT promoter by DNA methylation is mediated by critical CpG sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103181200

Additional organizational features of the murine folylpolyglutamate synthetase gene. Two remotely situated exons encoding an alternate 5' end and proximal open reading frame under the control of a second promoter

21 January 2018

1 reference

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Biochemistry of multidrug resistance mediated by the multidrug transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103181200

P-glycoprotein confers methotrexate resistance in 3T6 cells with deficient carrier-mediated methotrexate uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103181200

Cross-resistance to antifolates in multidrug resistant cell lines with P-glycoprotein or multidrug resistance protein expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103181200

P-glycoprotein-mediated methotrexate resistance in CCRF-CEM sublines deficient in methotrexate accumulation due to a point mutation in the reduced folate carrier gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103181200

Dipyridamole inhibits reversion by thymidine of methotrexate effect and increases drug uptake in Sarcoma 180 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103181200

Repression of human reduced folate carrier gene expression by wild type p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103181200

Mutations in the reduced-folate carrier affect protein localization and stability

21 January 2018

1 reference

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The tumour suppressor protein p53 can repress transcription of cyclin B.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M103181200

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30 July 2017

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