Functional studies of Plasmodium falciparum dipeptidyl aminopeptidase I using small molecule inhibitors and active site probes (Q34088922)

30 July 2017

title

Functional studies of Plasmodium falciparum dipeptidyl aminopeptidase I using small molecule inhibitors and active site probes (English)

1 reference

30 July 2017

main subject

Plasmodium falciparum

0 references

6

Matthew Bogyo

1 reference

30 July 2017

Edgar Deu

1

1 reference

30 July 2017

Melissa J Leyva

2

1 reference

30 July 2017

Victoria E Albrow

3

1 reference

30 July 2017

Mark J Rice

4

1 reference

30 July 2017

Jonathan A Ellman

5

1 reference

30 July 2017

publication date

1 August 2010

1 reference

30 July 2017

published in

Chemistry and Biology

1 reference

30 July 2017

volume

17

1 reference

30 July 2017

issue

8

1 reference

30 July 2017

page(s)

808-819

1 reference

Use of activity-based probes to develop high throughput screening assays that can be performed in complex cell extracts.

30 July 2017

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1 reference

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5 July 2018

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5 July 2018

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5 July 2018

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New roles for perforins and proteases in apicomplexan egress

5 July 2018

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Evidence for catalytic roles for Plasmodium falciparum aminopeptidase P in the food vacuole and cytosol

5 July 2018

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Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia

5 July 2018

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5 July 2018

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Roles of proteases during invasion and egress by Plasmodium and Toxoplasma

5 July 2018

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Malarial proteases and host cell egress: an 'emerging' cascade

5 July 2018

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Identification of a new class of nonpeptidic inhibitors of cruzain

5 July 2018

1 reference

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Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum

5 July 2018

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5 July 2018

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Roles for two aminopeptidases in vacuolar hemoglobin catabolism in Plasmodium falciparum

5 July 2018

1 reference

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Characterization and optimization of selective, nonpeptidic inhibitors of cathepsin S with an unprecedented binding mode

5 July 2018

1 reference

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Protease inhibitors and their peptidomimetic derivatives as potential drugs

5 July 2018

1 reference

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The crystal structure of human dipeptidyl peptidase I (cathepsin C) in complex with the inhibitor Gly-Phe-CHN2.

5 July 2018

1 reference

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Plasmepsins as potential targets for new antimalarial therapy

5 July 2018

1 reference

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Comparative whole genome transcriptome analysis of three Plasmodium falciparum strains

5 July 2018

1 reference

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Activity-based probes that target diverse cysteine protease families

5 July 2018

1 reference

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5 July 2018

Hemoglobin degradation.

1 reference

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Substrate activity screening: a fragment-based method for the rapid identification of nonpeptidic protease inhibitors

5 July 2018

1 reference

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In vitro antimalarial drug susceptibility in Thai border areas from 1998-2003.

5 July 2018

1 reference

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The Plasmodium falciparum sexual development transcriptome: a microarray analysis using ontology-based pattern identification

5 July 2018

1 reference

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Cysteine proteases of malaria parasites

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929396

Location, location, location: trafficking and function of secreted proteases of Toxoplasma and Plasmodium

5 July 2018

1 reference

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A Plasmodium falciparum dipeptidyl aminopeptidase I participates in vacuolar hemoglobin degradation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929396

The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum

5 July 2018

1 reference

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Discovery of gene function by expression profiling of the malaria parasite life cycle

5 July 2018

1 reference

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Irreversible inhibitors of serine, cysteine, and threonine proteases

5 July 2018

1 reference

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A role for the protease falcipain 1 in host cell invasion by the human malaria parasite

5 July 2018

1 reference

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The future outlook of antimalarial drugs and recent work on the treatment of malaria

5 July 2018

1 reference

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Cysteine proteases of malaria parasites: targets for chemotherapy

5 July 2018

1 reference

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5 July 2018

1 reference

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Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis

5 July 2018

1 reference

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Structure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteases

5 July 2018

1 reference

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Tetrameric dipeptidyl peptidase I directs substrate specificity by use of the residual pro-part domain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929396

Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929396

Hemoglobin metabolism in the malaria parasite Plasmodium falciparum

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929396

Artemisinin-resistant malaria in Asia.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929396

On the location of the aminopeptidase N homolog PfA-M1 in Plasmodium falciparum

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929396

In vivo inhibition of serine protease processing requires a high fractional inhibition of cathepsin C.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929396

Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929396

Effects on growth, hemoglobin metabolism and paralogous gene expression resulting from disruption of genes encoding the digestive vacuole plasmepsins of Plasmodium falciparum.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929396

Identification of selective, nonpeptidic nitrile inhibitors of cathepsin s using the substrate activity screening method

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929396

Gene disruptions demonstrate independent roles for the four falcipain cysteine proteases of Plasmodium falciparum

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929396

The role of Plasmodium falciparum food vacuole plasmepsins

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929396

Genetic disruption of the Plasmodium falciparum digestive vacuole plasmepsins demonstrates their functional redundancy

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929396

Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20797610

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CHEMBIOL.2010.06.007

1 reference

release_7ksxisrha5apdhggwhtl6gkmhm

30 July 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/7ksxisrha5apdhggwhtl6gkmhm

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMC publication ID

2929396

1 reference

30 July 2017

1 reference